Reducose Mulberry Extract
Also known as: Mulberry leaf extract, Reducose, _Morus alba_ L.
Overview
Mulberry leaf extract, derived from the leaves of the _Morus alba_ tree, is a botanical supplement rich in bioactive compounds, notably 1-deoxynojirimycin (DNJ), gallic acid, and various flavonoids. Its primary use is in managing blood glucose levels, especially following carbohydrate intake, through inhibition of intestinal glucose absorption. The research surrounding mulberry leaf extract is expanding, with multiple randomized controlled trials (RCTs) and systematic reviews highlighting its potential effectiveness. The extract works by inhibiting enzymes such as sucrase and maltase, contributing to lower postprandial glucose and insulin responses. The evidence backing its effects is generally of high quality, making it a promising candidate for glucose management strategies.
Benefits
The primary benefit of mulberry leaf extract is its ability to significantly reduce postprandial blood glucose levels. Clinical studies have shown that it can decrease the incremental area under the curve (iAUC) for glucose by 14.0% to 22.0%, and insulin levels by 23.8% to 38% compared to placebo. These effects are particularly noted in both normoglycaemic healthy adults and individuals with type 2 diabetes, indicating broader applicability. Furthermore, the extract may facilitate the translocation of the GLUT4 glucose transporter, which enhances glucose uptake in cells, contributing to its anti-diabetic properties. The onset of these benefits is rapid, occurring within 120 minutes post-ingestion, further supporting its efficacy as a dietary adjunct for blood sugar management.
How it works
Mulberry leaf extract functions primarily by inhibiting the activity of intestinal enzymes such as sucrase, maltase, isomaltase, and lactase, which are essential for carbohydrate digestion and glucose absorption. This inhibition results in reduced glucose uptake from the gut into the bloodstream. Additionally, the extract may promote the translocation of the GLUT4 receptor to the cell membrane, facilitating glucose uptake in insulin-responsive tissues. This dual mechanism of action helps to regulate blood glucose levels effectively, particularly after meals.
Side effects
Mulberry leaf extract is generally well-tolerated, and clinical studies have not reported any significant gastrointestinal symptoms or adverse effects exceeding the 5% threshold. No uncommon or rare side effects have been noted in the reviewed literature. However, it is recommended that individuals on diabetes medications consult healthcare providers prior to use, as the extract may amplify their effects. Pregnant or breastfeeding women should exercise caution due to insufficient safety data in these populations. Overall, while the safety profile appears robust, monitoring blood glucose levels is advised for patients with diabetes to avoid any potential destabilization of their condition.
Dosage
The minimum effective dose of mulberry leaf extract (Reducose) is suggested to be around 200-250 mg per intake, providing approximately 10-12.5 mg of DNJ. Optimal dosage ranges from 200 mg to 500 mg have shown efficacy, with specific doses of 250 mg leading to significant reductions in blood glucose and insulin levels. It is recommended to take the extract before meals to maximize glucose absorption inhibition. While no maximum safe dose has been explicitly defined, doses up to 500 mg have been utilized without adverse effects. The extract is commonly available in capsule form, and its absorption may be enhanced when taken alongside carbohydrate-containing meals.
FAQs
Is mulberry leaf extract safe?
Yes, mulberry leaf extract is considered safe for most individuals, but those with diabetes should monitor their blood glucose levels while using it.
How should I take mulberry leaf extract?
It is recommended to take mulberry leaf extract before meals to effectively reduce postprandial glucose spikes.
What effects can I expect from using this supplement?
Users typically experience a reduction in postprandial blood glucose and insulin levels when taking mulberry leaf extract.
Is mulberry leaf extract a substitute for diabetes medication?
No, it should not replace standard diabetes treatments but can serve as a dietary adjunct.
Research Sources
- https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0172239 – This randomized controlled trial demonstrated significant reductions in blood glucose and insulin levels following the administration of mulberry leaf extract in healthy adults, indicating its potential for glucose management.
- https://pubmed.ncbi.nlm.nih.gov/28225835/ – The findings of this study suggest that different doses of mulberry leaf extract led to marked decreases in postprandial glucose and insulin levels, supporting its application in dietary management.
- https://onlinelibrary.wiley.com/doi/10.1155/2022/9282154 – This systematic review and meta-analysis consolidated data from various RCTs, reinforcing the efficacy of mulberry leaf extract in managing blood sugar levels, and pointed out a need for more rigorous trials to validate current findings.
