Rehmannia Glutinosa Extract
Also known as: Chinese Foxglove, Di Huang, Sheng Di Huang, Rehmannia glutinosa
Overview
*Rehmannia glutinosa* (Gaertn.) DC. is an herbal extract from the *Scrophulariaceae* family, widely utilized in Traditional Chinese Medicine (TCM). This plant is noted for its potential to nourish Yin and support kidney health. It contains over 70 bioactive compounds, including iridoids, polysaccharides, and amino acids, which contribute to its therapeutic effects. Commonly employed for managing conditions such as diabetes and diabetic nephropathy, *Rehmannia glutinosa* is gaining interest in modern research, particularly concerning its active constituents like catalpol. While the quality of evidence is variable, there is moderate research maturity indicating its effects and benefits, especially in renal and metabolic health.
Benefits
The key benefits associated with *Rehmannia glutinosa* include significant anti-diabetic properties, primarily attributed to catalpol, which improves renal function and lowers fasting blood glucose levels. Polysaccharides derived from the plant have demonstrated notable hypoglycemic activity. Additionally, *Rehmannia glutinosa* exhibits antioxidant and anti-inflammatory effects, offering protective benefits against various diseases, including cardiovascular conditions. Research suggests enhanced renal function and glucose modulation, particularly beneficial for individuals suffering from diabetes and kidney-related disorders. However, while outcomes appear promising, the necessity for further high-quality clinical trials is pressing.
How it works
*Rehmannia glutinosa* acts through several biological pathways, primarily by reducing inflammation and oxidative stress, which are critical in metabolic disorders. The active compound catalpol is believed to enhance lipid metabolism and modulate glucose homeostasis. Its renal protective effects may include delaying renal fibrosis and promoting autophagy. Through these mechanisms, it influences various body systems, including endocrine and cardiovascular functions, though the exact molecular targets require further investigation.
Side effects
Overall, *Rehmannia glutinosa* is considered safe when appropriately used, particularly in traditional contexts. Common side effects are not widely documented in scientific literature, with gastrointestinal upset noted as a potential but uncommon reaction (1-5% occurrence). There are no comprehensive data reporting rare side effects (<1%). Caution is warranted for individuals taking diabetes medications or other herbal supplements, as potential interactions may exist that have not been extensively studied. Pregnant and breastfeeding individuals should avoid using this herb due to insufficient safety data. Furthermore, individuals with severe kidney or liver dysfunction are advised to consult healthcare professionals before use.
Dosage
Dosage guidelines for *Rehmannia glutinosa* are not well-established in scientific literature, reflecting the variability in traditional practices. Optimal dosages are yet to be definitively defined, although extracts are often more concentrated than traditional forms. While a specific effective dosage remains unspecified, practitioners frequently combine it with other herbs in TCM. Catalpol, one of its active compounds, shows good bioavailability, which should be considered when formulating dosing regimens. Due to the lack of established maximum safe doses, caution is recommended in assessing individual needs and consulting healthcare providers.
FAQs
Is *Rehmannia glutinosa* safe to use with other medications?
Consult with a healthcare provider before combining *Rehmannia glutinosa* with other medications, particularly those for diabetes.
How long does it take to see results from *Rehmannia glutinosa*?
Benefits may take several weeks to become noticeable, depending on the health condition treated.
Can I take *Rehmannia glutinosa* during pregnancy?
It is not recommended for use during pregnancy or breastfeeding due to insufficient safety data.
What is the best time to take *Rehmannia glutinosa*?
It is typically taken in the morning, often in combination with other TCM herbs.
Is *Rehmannia glutinosa* a substitute for conventional medicine?
No, it should not be used as a substitute for conventional medical treatment without professional guidance.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1192694/full – This systematic review evaluates the effects of catalpol on diabetic nephropathy. Findings indicate significant improvements in renal function and reductions in blood glucose levels in animal studies. However, the review highlights the need for human trials and improved methodological consistency.
- https://pubmed.ncbi.nlm.nih.gov/36634722/ – A review of polysaccharides derived from *Rehmannia glutinosa*, highlighting their hypoglycemic, antioxidant, and immune-enhancing effects. The study describes pharmacological activities but notes limitations in clinical application data.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.942657/full – This review addresses the botany, chemistry, and pharmacology of *Rehmannia glutinosa*, indicating its wide pharmacological actions, including effects on immune and cardiovascular systems. The need for systematic studies confirming clinical efficacy is emphasized.
- https://pubmed.ncbi.nlm.nih.gov/18407446/ – An analysis of traditional uses and potential modern applications of *Rehmannia glutinosa*, discussing its various beneficial properties and advocating for further clinical research to validate traditional claims.
- https://onlinelibrary.wiley.com/doi/10.1155/2021/5591573 – A comprehensive evaluation of the pharmacological principles underlying *Rehmannia glutinosa*, focusing on its effects across different body systems and necessitating systematic investigations to establish clinical relevance.
Supplements Containing Rehmannia Glutinosa Extract
Mountain Alchemy Pine Pollen Elixir Tincture
Raw Forest Foods
Left-Side Replenishing Teapills
Plum Flower
Lilium Teapills
Plum Flower
China Tung Hsueh Pills
Plum Flower
Eight Flavor Rehmannia Teapills
Plum Flower
Golden Book Teapills
Min Shan
Long Dan Xie Gan Wan
Min Shan