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Rehmannia Glutinosa Root Extract

Also known as: Rehmannia glutinosa (Gaertn.) DC., Chinese Foxglove, Di Huang, Sheng Di Huang, Rehmannia glutinosa

Overview

Rehmannia glutinosa, also known as Chinese Foxglove, is a plant native to China with a long history in traditional Chinese medicine. It is primarily used to nourish Yin and support kidney health. The plant contains over 70 compounds, including iridoids like catalpol, saccharides, amino acids, and trace elements. Traditionally, it has been used to address conditions such as diabetes and diabetic nephropathy. Current research is focused on its active compounds, particularly catalpol and polysaccharides, to understand their specific mechanisms and potential therapeutic benefits. While research is ongoing, the quality of available evidence varies, highlighting the need for more clinical studies to confirm its efficacy and safety.

Benefits

Rehmannia glutinosa, particularly its compounds catalpol and polysaccharides, exhibits several potential health benefits. Catalpol has demonstrated protective effects against diabetic nephropathy in animal models by improving renal function and reducing inflammation. Polysaccharides present in the plant show antioxidant, hypoglycemic, and immune-enhancing activities. Additional research suggests potential antitumor, immunomodulatory, neuroprotective, and cardioprotective effects associated with these polysaccharides. While these findings are promising, most studies are preclinical, and further human trials are needed to confirm these benefits and determine their clinical significance, especially for individuals with diabetes or kidney issues.

How it works

Rehmannia glutinosa exerts its effects through multiple biological pathways. Catalpol, a key iridoid compound, is believed to reduce inflammation and oxidative stress, thereby improving podocyte apoptosis in the kidneys. Polysaccharides contribute through their antioxidant and immune-modulating properties. The plant interacts with the endocrine, cardiovascular, and immune systems. While the exact molecular targets are not fully understood, the mechanisms likely involve pathways related to inflammation, oxidative stress, and immune response. Further research is needed to fully elucidate the absorption, bioavailability, and specific molecular interactions in humans.

Side effects

Rehmannia glutinosa is generally considered safe based on its traditional use, but comprehensive modern clinical safety data are limited. Common side effects are not well-documented, but potential gastrointestinal upset has been reported. Due to limited data, rare side effects are not well-defined. There is a potential for interactions with diabetes medications or other herbs, but these have not been extensively studied. Rehmannia glutinosa is contraindicated during pregnancy and breastfeeding due to a lack of safety data. Caution is advised for individuals with severe kidney or liver dysfunction. Further research is needed to fully characterize its safety profile and potential adverse effects.

Dosage

Due to limited human studies, specific dosage recommendations for Rehmannia glutinosa are not well-established. Traditional use involves decoctions or extracts, with dosages varying widely. A minimum effective dose and maximum safe dose have not been determined for humans. It is typically taken with meals to minimize potential gastrointestinal upset. Common forms include decoctions, capsules, and tablets. Bioavailability may be influenced by extraction methods and formulation. Consult with a healthcare provider before using Rehmannia glutinosa to determine an appropriate dosage and ensure safety, especially if taking other medications.

FAQs

How should I take Rehmannia glutinosa?

It is best taken with meals to reduce potential gastrointestinal upset. Consult with a healthcare provider to determine the appropriate form (decoction, capsule, or tablet) and dosage for your specific needs.

Is Rehmannia glutinosa safe?

While traditionally used, modern safety data are limited. It's contraindicated in pregnancy and breastfeeding. Consult a healthcare provider before use, especially if you have existing health conditions or are taking other medications.

What are the expected benefits of taking Rehmannia glutinosa?

Potential benefits include support for kidney health and diabetes management, but results may vary. It should not be used as a substitute for conventional medical treatment. Consult with your doctor.

Can Rehmannia glutinosa interact with other medications?

Yes, there is a potential for interactions with diabetes medications or other herbs. It is crucial to consult with a healthcare provider to avoid any adverse effects.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/37621314/ – A systematic review of 12 animal studies (n=231) found that catalpol, a compound in Rehmannia glutinosa, improved renal function in diabetic nephropathy models by reducing inflammation and oxidative stress. The study highlights the potential of catalpol as a therapeutic agent for diabetic kidney disease, but emphasizes the need for human trials to confirm these findings.
https://pubmed.ncbi.nlm.nih.gov/36634722/ – This review highlights that Rehmannia glutinosa polysaccharides exhibit antioxidant, hypoglycemic, and immune-enhancing effects. While the review suggests potential health benefits, it also notes the lack of human clinical trials, indicating a need for further research to validate these effects in humans.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1192694/full – This review provides a comprehensive overview of Rehmannia glutinosa's traditional use and pharmacological activities. It emphasizes the plant's historical significance in traditional Chinese medicine and its wide range of potential therapeutic applications, while also acknowledging that historical use does not guarantee modern clinical efficacy.
https://pubmed.ncbi.nlm.nih.gov/18407446/ – This study investigates the protective effects of catalpol against diabetic nephropathy. The research indicates that catalpol can improve renal function and reduce inflammation in animal models, suggesting its potential as a therapeutic agent for diabetic kidney disease.
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01413/full – This research explores the immunomodulatory effects of Rehmannia glutinosa. The study suggests that components of the plant can modulate immune responses, potentially contributing to its therapeutic effects in various conditions.