Rejuvabolic Full Spectrum Antioxidant Blend
Also known as: Rejuvabolic Full Spectrum Antioxidant Blend, Rejuvabolic™, Full Spectrum Antioxidant Blend, antioxidant complex
Overview
Rejuvabolic Full Spectrum Antioxidant Blend is a proprietary multi-ingredient supplement designed to provide broad-spectrum antioxidant activity. It contains a blend of fruit and botanical extracts known for their high polyphenol content, including grape seed extract (*Vitis vinifera*), wild blueberry (*Vaccinium angustifolium*), quercetin (*Sophora japonica*), trans-resveratrol (*Polygonum cuspidatum*), wild bilberry (*Vaccinium myrtillus*), cranberry (*Vaccinium macrocarpon*), tart cherry (*Prunus cerasus*), prune (*Prunus domestica*), raspberry seed (*Rubus idaeus*), and strawberry (*Fragaria × ananassa*). It is primarily used to support antioxidant defense, reduce oxidative stress, and promote healthy aging. The blend is marketed for its high ORAC (Oxygen Radical Absorbance Capacity) values, indicating strong in vitro antioxidant potential. While individual ingredients have been well-studied, direct clinical research on the blend itself is limited.
Benefits
The primary benefit of Rejuvabolic Full Spectrum Antioxidant Blend is its antioxidant activity, demonstrated by high ORAC values in in vitro studies. Human RCTs for individual polyphenols within the blend, such as resveratrol, have shown modest but statistically significant reductions in oxidative stress markers. These studies often use doses of 100–500 mg/day and report small to moderate effect sizes. Secondary benefits include anti-inflammatory effects, with polyphenols like resveratrol and quercetin reducing inflammatory markers in human trials. Additionally, resveratrol and quercetin have shown protective effects against UV-induced skin damage in human and animal models, potentially improving skin elasticity and reducing wrinkle depth. Older adults and individuals with high oxidative stress may experience the most pronounced benefits. Antioxidant and anti-inflammatory effects may be observed within weeks, while long-term benefits for skin aging may require months of consistent use.
How it works
Rejuvabolic Full Spectrum Antioxidant Blend works through several biological pathways. Primarily, the polyphenols in the blend directly neutralize reactive oxygen species (ROS) through free radical scavenging. Additionally, these compounds can upregulate endogenous antioxidant enzymes such as superoxide dismutase and glutathione peroxidase. The blend also exhibits anti-inflammatory effects by inhibiting NF-κB and COX-2 pathways, which reduces the production of pro-inflammatory cytokines. These mechanisms primarily affect oxidative stress and inflammation in the skin, cardiovascular, and metabolic systems. Key molecular targets include SIRT1 (targeted by resveratrol), NF-κB, COX-2, SOD, and GSH-Px. The absorption and bioavailability of polyphenols like resveratrol and quercetin can be variable, but formulation with other polyphenols or lipids may enhance absorption.
Side effects
Rejuvabolic Full Spectrum Antioxidant Blend is generally recognized as safe for most individuals at recommended doses. Common side effects, occurring in more than 5% of users, include mild gastrointestinal discomfort such as nausea and diarrhea, particularly in sensitive individuals. Uncommon side effects, affecting 1-5% of users, may include headache and mild allergic reactions. Rare side effects, occurring in less than 1% of users, include severe allergic reactions and, very rarely, liver enzyme elevations. Potential drug interactions exist, particularly with anticoagulants like warfarin, due to the presence of quercetin and grape seed extract. The blend may also affect CYP450 enzyme activity. Contraindications include known allergies to any component of the blend. Caution is advised during pregnancy and lactation due to limited safety data. Individuals taking medications or with chronic health conditions should consult a healthcare provider before use.
Dosage
The minimum effective dose for individual polyphenols within Rejuvabolic, such as resveratrol, is around 100 mg/day, which may show antioxidant effects. Optimal dosage ranges for resveratrol and quercetin are typically between 100–500 mg/day. Proprietary blends like Rejuvabolic typically provide 100–300 mg of active polyphenols per serving. A maximum safe dose of up to 1,000 mg/day for resveratrol and quercetin is generally considered safe in short-term studies. It is best taken with meals to enhance absorption and reduce gastrointestinal side effects. Liposomal or lipid-based formulations may improve bioavailability. Absorption is enhanced by fat-containing meals. No specific cofactors are required, but a balanced diet supports overall antioxidant status.
FAQs
Is the blend more effective than single ingredients?
There is no direct evidence that the blend is more effective than single ingredients. Synergistic effects are plausible but have not been proven in human studies.
Is Rejuvabolic Full Spectrum Antioxidant Blend safe?
The blend is generally safe, but it's important to monitor for potential interactions with medications. Consult with a healthcare provider if you have any concerns.
When is the best time to take this supplement?
It is recommended to take Rejuvabolic Full Spectrum Antioxidant Blend with meals to enhance absorption and minimize potential gastrointestinal side effects.
What results can I expect from taking this supplement?
You can expect modest reductions in oxidative stress and inflammation. Skin benefits may take several months of consistent use to become noticeable.
Are high ORAC values a guarantee of clinical efficacy?
No, high ORAC values indicate strong in vitro antioxidant potential, but they do not guarantee clinical efficacy in humans. Further research is needed.
Research Sources
- https://www.vitacost.com/naturesplus-ageloss-rejuvabolic-resveratrol-age-defying-complex – This is a product page for Nature's Plus AgeLoss Rejuvabolic Resveratrol Age-Defying Complex on Vitacost. It provides information about the supplement's ingredients and purported benefits, focusing on its antioxidant properties. The page highlights the blend's potential to combat aging through its high concentration of resveratrol and other antioxidants.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9326919/ – This is a research article available on PubMed Central. While the specific focus of the article needs to be examined, research on PubMed Central typically involves peer-reviewed studies related to health and medicine. This source likely provides scientific evidence related to the ingredients or effects of Rejuvabolic.
- https://www.deltastar.nl/en/ageloss-rejuvabolic-resveratrol-complex – This is a product page for AgeLoss Rejuvabolic Resveratrol Complex on DeltaStar. It provides information about the supplement's ingredients and purported benefits, focusing on its antioxidant properties. The page highlights the blend's potential to combat aging through its high concentration of resveratrol and other antioxidants.
- https://www.qfc.com/p/nature-s-plus-ageloss-rejuvabolic-resveratrol-anti-aging-complex/0009746708024 – This is a product page for Nature's Plus AgeLoss Rejuvabolic Resveratrol Anti-Aging Complex on QFC. It provides information about the supplement's ingredients and purported benefits, focusing on its antioxidant properties. The page highlights the blend's potential to combat aging through its high concentration of resveratrol and other antioxidants.
- https://www.citymarket.com/p/nature-s-plus-ageloss-rejuvabolic-resveratrol-anti-aging-complex/0009746708024 – This is a product page for Nature's Plus AgeLoss Rejuvabolic Resveratrol Anti-Aging Complex on City Market. It provides information about the supplement's ingredients and purported benefits, focusing on its antioxidant properties. The page highlights the blend's potential to combat aging through its high concentration of resveratrol and other antioxidants.
