Rephyll
Also known as: Rephyll, Caryophyllene, β-Caryophyllene
Overview
β-Caryophyllene is a naturally occurring sesquiterpene found in the essential oils of various plants, particularly clove, rosemary, and hops. It is recognized for its potential therapeutic effects, primarily in dietary supplements aimed at reducing muscle fatigue and improving endurance. This compound is notable for its anti-inflammatory and antioxidant properties, contributing to muscle recovery and performance enhancement. Current research is still in its emerging phase, with limited clinical trials primarily focused on its role in alleviating delayed onset muscle soreness (DOMS). The existing evidence consists of one randomized controlled trial, indicating that β-caryophyllene has a promising yet not fully understood role in enhancing physical performance and recovery.
Benefits
The primary benefit of β-Caryophyllene, as shown in a study with 110 untrained individuals, is its significant improvement in muscle fatigue and overall aerobic function after 30 days of supplementation. Key findings include reduced ratings of perceived exertion (RPE) and improved ATP reserves and pain scores, suggesting beneficial effects on muscle recovery and performance. Secondary benefits include enhanced aerobic efficiency with lower oxygen consumption during exercise and improved lactic acid expulsion. This study particularly highlights its potential for individuals engaged in resistance or power exercise, with evidence pointing to significant improvements in muscle fatigue and soreness reduction.
How it works
β-Caryophyllene functions primarily through its anti-inflammatory properties, aiding in the reduction of muscle damage while enhancing energy metabolism. It may positively affect energy production pathways by increasing ATP reserves and facilitating lactic acid clearance during physical activity, thus contributing to improved aerobic performance and diminished muscle fatigue.
Side effects
Currently, no adverse effects have been reported in clinical trials involving β-Caryophyllene supplementation, indicating a favorable safety profile. The study explicitly noted no instances of common or uncommon side effects, with a comprehensive safety assessment showing no adverse events in both the Rephyll and placebo groups over the 30-day period. However, while no drug interactions or contraindications have been identified, caution is advisable for specific populations such as pregnant women or children, as these groups were not included in studies. Though β-Caryophyllene appears safe for general use, the long-term effects and interactions remain uncharted, warranting further research.
Dosage
The studied dosage of β-Caryophyllene is 250 mg per capsule, taken twice daily, totaling 500 mg per day. This dosage was administered in the morning following breakfast. Though this is the only established effective dose, there are currently no defined maximum safe doses or alternative dosing recommendations in the available literature. The absorption characteristics and potential interactions with other substances are also not thoroughly addressed in the existing studies, emphasizing the need for caution when considering supplementation.
FAQs
Is β-Caryophyllene safe?
The study indicates no adverse events, but long-term safety and interactions with medications remain under-researched.
When should I take β-Caryophyllene?
Capsules are recommended to be taken in the morning after breakfast for optimal results.
What results can I expect from taking β-Caryophyllene?
Significant improvements in muscle fatigue, perceived exertion, and pain scores can be expected after 30 days of use.
Can anyone take β-Caryophyllene?
While generally safe, special populations like pregnant women or individuals with chronic conditions should approach with caution due to lack of specific studies.
Research Sources
- http://www.fortunejournals.com/articles/effect-of-a-phytochemical-formulation-on-muscle-fatigue-energy-recovery.pdf – This randomized controlled trial assessed the effects of β-Caryophyllene on muscle fatigue and energy recovery in untrained individuals over 30 days. Results showed significant improvements in muscle fatigue and ratings of perceived exertion compared to the placebo group, suggesting its potential as a performance enhancer.
