Reservie Complex Blend
Also known as: Resveratrol, trans-Resveratrol, 3,5,4'-Trihydroxy-trans-stilbene
Overview
Resveratrol is a polyphenol compound identified chemically as 3,5,4'-trihydroxy-trans-stilbene (C14H12O3) and is naturally found in plants such as grapes, berries, peanuts, and certain vines. It is known for potential health benefits related to cardiovascular wellness, anti-inflammatory properties, and antioxidant functions. Resveratrol is primarily utilized in dietary supplements aimed at mitigating chronic diseases like diabetes, arthritis, and other inflammatory conditions. The research into its effects is extensive, including preclinical, animal, and human studies, though variability exists in the quality and consistency of clinical trials, particularly regarding sample sizes, dosages, and durations. Notably, resveratrol is recognized for its effects on inflammation and cell longevity through various biological pathways, including crucial roles in immune response and cellular stress.
Benefits
Resveratrol has several evidence-backed benefits: significant anti-inflammatory effects, particularly evidenced by a meta-analysis indicating substantial reductions in TNF-α levels (SMD: -13.50; P=0.002). Additionally, it has shown improvements in bone health through increased serum and bone alkaline phosphatase levels, notably at dosages of 1000 mg or more. Specific populations, such as individuals with metabolic syndrome and postmenopausal women, report enhancements in metabolic and bone markers. Cardiovascular benefits are also observed, including reduced inflammatory markers in conditions such as rheumatoid arthritis. However, research quality varies, and while results are promising, further high-quality studies are necessary for confirmation.
How it works
Resveratrol exerts its effects through interactions with key biological pathways, primarily the NF-κB and SIRT1 pathways. Its anti-inflammatory properties are realized by inhibiting pro-inflammatory cytokines, such as TNF-α, while activating SIRT1, which plays a role in cellular stress responses and aging. These mechanisms contribute to resveratrol's broad impact on multiple organ systems, including cardiovascular and neurological health. However, resveratrol is noted for its limited bioavailability, as it undergoes rapid metabolism, which may affect the extent of its beneficial effects.
Side effects
Resveratrol is generally considered safe at studied dosages, but its long-term usage lacks comprehensive safety data. Common gastrointestinal side effects (>5% incidence) include nausea and diarrhea. Less commonly reported side effects (1-5%) do not include significant adverse effects, and rare severe side effects (<1%) have not been documented in the literature. Caution is advised when used with anticoagulants due to potential interactions that could increase bleeding risk. Individuals with bleeding disorders should be particularly careful. Pregnant or breastfeeding women are encouraged to consult a healthcare provider before supplementation because of limited safety data in these populations.
Dosage
The recommended daily dosage of resveratrol varies based on the condition being treated, with a minimum effective dose ranging from 100-500 mg. Higher dosages of 1000 mg or more have shown significant benefits, particularly for inflammation and bone health in several studies. Although no maximum safe dose is officially established, clinical studies have utilized dosages up to 2000 mg without serious adverse effects. Consistency in daily dosing is generally emphasized, and there are no specific timing recommendations. Resveratrol supplements are often taken in capsule or tablet form, with enhanced absorption noted when paired with fatty foods.
FAQs
Is resveratrol safe to take long-term?
While resveratrol is generally regarded as safe, long-term effects and interactions with medications require further research.
When should I take resveratrol?
Daily supplementation is recommended, and absorption can be enhanced when taken with fatty meals.
How soon can I expect results from resveratrol?
Improvements in inflammatory markers and bone health may be observed within several months of consistent use.
Is resveratrol a miracle supplement?
Resveratrol is not a cure-all and should be integrated into a comprehensive health regimen for best results.
Research Sources
- https://libraryinfo.bhs.org/systematicreviews – This systematic review and meta-analysis examines resveratrol's effects in sepsis models, finding significant reductions in TNF-α levels, thus suggesting its potential role in inflammation management.
- https://www.spandidos-publications.com/10.3892/br.2018.1169 – A meta-analysis focused on bone biomarkers indicating resveratrol's effectiveness in enhancing bone formation markers, particularly relevant for metabolic syndrome and type 2 diabetes patients.
- https://pubmed.ncbi.nlm.nih.gov/31478479/ – This randomized controlled trial demonstrated that resveratrol significantly improved joint health in rheumatoid arthritis patients, showcasing marked reductions in disease activity.
- https://bmjopen.bmj.com/content/8/6/e017858 – A clinical trial presenting resveratrol's beneficial effects on inflammatory markers in patients with various conditions, with a focus on dosages above the common threshold for notable improvements.
- https://www.nmi.health/resveratrol-a-review-of-clinical-use-and-efficacy/ – This review provides a comprehensive overview of resveratrol’s clinical applications, evaluating its efficacy in diverse health areas while emphasizing the need for further high-quality studies.
Supplements Containing Reservie Complex Blend
Reservie Trans-Resveratrol 500 mg
The Vitamin Shoppe
Reservie Trans-Resveratrol 250 mg
The Vitamin Shoppe
Reservie Trans-Resveratrol 500 mg Std.
The Vitamin Shoppe
Reservie Trans-Resveratrol 500 mg Std.
The Vitamin Shoppe
Reservie Trans Resveratrol Standardized 250 mg
The Vitamin Shoppe