Restharrow
Also known as: Restharrow, Spiny Restharrow, Ononis spinosa
Overview
Restharrow (Ononis spinosa) is a perennial herb native to Europe and parts of Asia, traditionally used in herbal medicine primarily for its diuretic properties and to support urinary tract function. It contains bioactive compounds such as flavonoids, isoflavonoids, and essential oils. The supplement is mainly applied for mild urinary tract infections (UTIs), kidney stones, and edema. Despite its traditional use, the scientific literature on Restharrow itself is limited, with most clinical evidence being older or of low methodological quality. There is no recent systematic review or meta-analysis specifically on Restharrow available in major databases such as PubMed Central, Web of Science, or Cochrane Library.
Benefits
Traditionally, Restharrow is used as a mild diuretic to increase urine output and support urinary tract health. However, high-quality clinical trials confirming these effects are scarce. Some in vitro and animal studies suggest anti-inflammatory and antimicrobial properties, but these have not been robustly confirmed in humans. It is mainly used in adults with mild urinary complaints; there is no strong evidence for use in other populations or conditions. The effect sizes and clinical significance are not well established due to a lack of rigorous randomized controlled trials (RCTs) meeting inclusion criteria (adequate sample size, controls, etc.). Traditional use suggests effects within days to weeks, but no validated clinical timelines exist.
How it works
Restharrow’s diuretic effect is thought to be due to flavonoids and essential oils that may increase renal blood flow and glomerular filtration rate, promoting urine production. Potential anti-inflammatory effects may involve inhibition of pro-inflammatory mediators, but the specific molecular targets are not clearly defined. Absorption and bioavailability data are limited; active constituents likely undergo metabolism in the gut and liver, influencing their systemic availability and activity.
Side effects
Restharrow is generally regarded as safe when used in traditional doses, with no serious adverse events reported in historical use. Common side effects are mild and occasionally include gastrointestinal discomfort. Allergic reactions are rare but possible. There are no well-documented drug interactions; however, caution is advised when combining it with other diuretics or medications that affect kidney function due to potential additive effects. Restharrow is not recommended for individuals with severe kidney disease or dehydration. Its safety in pregnancy and lactation has not been established, and therefore, its use in these populations is not advised.
Dosage
Traditional herbal preparations of Restharrow vary widely. Typical doses in herbal teas or extracts range from 2 to 6 grams of dried herb per day. There is no standardized dosing established from clinical trials due to the lack of rigorous studies. The timing of administration is usually spread over the day. Factors related to absorption and bioavailability of active compounds are not well studied, making it difficult to define optimal dosing for maximum efficacy or safety. There are no established upper limits or safety thresholds based on modern clinical research.
FAQs
Is Restharrow effective for urinary tract infections?
Evidence is insufficient; it may support mild symptoms but should not replace antibiotics for confirmed bacterial infections. Consult a healthcare professional for UTIs.
Is it safe for long-term use?
Traditional use suggests safety, but long-term clinical data are lacking. Continuous use should be discussed with a healthcare provider, especially for chronic conditions.
Can it be combined with other diuretics?
Caution is advised due to potential additive effects, which could lead to excessive fluid loss or electrolyte imbalances. Consult a doctor before combining.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/35833325/ – This systematic review and meta-analysis focused on resveratrol and its effects on endothelial function, showing significant improvements. It is not directly related to Restharrow but exemplifies a high-quality research standard.
- https://pubmed.ncbi.nlm.nih.gov/30515938/ – This meta-analysis investigated resveratrol's modest effects on obesity measures. Like the previous source, it is unrelated to Restharrow but serves as an example of a meta-analysis.
- https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.8112 – This systematic review on plant-derived supplements for menopausal symptoms included various herbs but did not specifically address Restharrow. It highlights the broader context of herbal supplement research.