Resveratrol Enriched Yeast
Also known as: 3,5,4'-trihydroxy-trans-stilbene, Resveratrol Enriched Yeast, Resveratrol
Overview
Resveratrol is a polyphenol compound found in various plants, including grapes, berries, and peanuts. It can also be produced through microbial fermentation, such as in resveratrol-enriched yeast. It is widely recognized for its potential health benefits, primarily its antioxidant and anti-inflammatory properties. Resveratrol has been studied for its potential to mimic caloric restriction and extend lifespan, particularly in animal models. While research is extensive, more clinical trials are needed to confirm its efficacy in humans. The quality of evidence varies, with some high-quality clinical trials alongside studies with limitations like small sample sizes or inconsistent dosing. Resveratrol is available in various forms, including capsules, tablets, and as a component of certain foods and beverages.
Benefits
Resveratrol has demonstrated antioxidant effects and may improve cardiovascular health by reducing inflammation and improving lipid profiles. A randomized controlled trial showed that 150 mg of resveratrol daily exhibited antioxidant effects and increased vitamin E levels in healthy volunteers with asymptomatic hypercholesterolemia. Furthermore, it may offer neuroprotective and anti-cancer properties, although more research is necessary to confirm these effects. Individuals with metabolic syndrome may benefit from resveratrol, as it has shown potential in improving metabolic parameters. The clinical significance of these effects is still under investigation, with results varying across different populations. The time course for observing benefits can vary depending on the condition being treated and the dosage used.
How it works
Resveratrol primarily acts through the activation of SIRT1, a protein involved in cellular metabolism and longevity. It interacts with various body systems, including the cardiovascular, metabolic, and nervous systems. Resveratrol targets multiple molecular pathways, including those involved in inflammation and oxidative stress. It also influences the production of antioxidant enzymes and modulates inflammatory cytokines. While resveratrol has low bioavailability when taken orally, certain formulations or co-administration with other compounds can improve its absorption.
Side effects
Resveratrol is generally considered safe, but high doses may cause gastrointestinal side effects such as diarrhea or nausea. Uncommon side effects include headaches or dizziness. Rare side effects may include allergic reactions. Resveratrol may interact with blood thinners and certain medications, potentially increasing the risk of bleeding. It is contraindicated in pregnancy and breastfeeding due to limited safety data. Individuals with bleeding disorders should consult a healthcare provider before use. It's important to adhere to recommended dosages to minimize the risk of adverse effects.
Dosage
The minimum effective dose of resveratrol typically starts at 100 mg per day. Optimal dosage ranges are often studied between 100 mg to 500 mg per day. It is generally considered safe up to 1,000 mg per day, although more research is needed to confirm long-term safety. Resveratrol is best taken with meals to reduce gastrointestinal side effects. Bioavailability can be improved with certain formulations, such as micronized resveratrol or combinations with piperine. Absorption may also be enhanced by co-administration with fatty meals. There are no specifically identified required cofactors for resveratrol's efficacy.
FAQs
How should I take resveratrol to minimize side effects?
Resveratrol can be taken with meals to reduce gastrointestinal side effects. It is important to consult a healthcare provider before starting any supplement regimen to determine the appropriate dosage and ensure it does not interact with any medications you are taking.
Is resveratrol safe for everyone?
Resveratrol is generally safe, but high doses may cause side effects. It is contraindicated in pregnancy and breastfeeding. Individuals with bleeding disorders or those taking blood thinners should consult a healthcare provider before use.
When is the best time to take resveratrol?
Resveratrol is best taken consistently at the same time each day, preferably with a meal to enhance absorption and reduce potential gastrointestinal discomfort. Consistency in timing can help maintain stable blood levels.
How long does it take to see the benefits of resveratrol?
It may take several weeks to notice the benefits of resveratrol. Individual responses can vary, and it is important to maintain a healthy lifestyle in addition to taking the supplement for optimal results.
Is resveratrol a substitute for a healthy diet and lifestyle?
No, resveratrol is not a substitute for a healthy diet and lifestyle. It should be used as a supplement to support overall health, not as a replacement for balanced nutrition and regular physical activity.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8226833/ – This article does not seem to contain the Apostolidou 2015 study. The article is about the effects of COVID-19 on the olfactory bulb. Therefore, the summary cannot be accurately provided.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10815776/ – This article does not seem to contain the Apostolidou 2015 study. The article is about the effects of growth differentiation factor 15. Therefore, the summary cannot be accurately provided.
- https://www.mdpi.com/2673-396X/5/2/16 – This review highlights resveratrol's potential benefits in various pathological conditions, including neoplastic diseases and neurodegeneration. It emphasizes the need for more clinical trials to confirm these effects in humans, suggesting that while preclinical studies are promising, further validation is required.
- https://journals.sagepub.com/doi/10.1177/1934578x1801300923 – This study investigates the effects of resveratrol on healthy volunteers with asymptomatic hypercholesterolemia. Participants received 150 mg of resveratrol daily, showing antioxidant effects and increased vitamin E levels, suggesting a potential role for resveratrol in improving antioxidant status.
- https://www.mdpi.com/2076-3417/14/11/4534 – This systematic review and meta-analysis examines the effects of resveratrol on metabolic syndrome features. The findings suggest potential benefits in improving metabolic parameters, indicating that resveratrol may be a useful adjunct in managing metabolic syndrome.
Supplements Containing Resveratrol Enriched Yeast
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