Rhapontic Rhubarb Root Extract
Also known as: Rheum rhaponticum, Rhapontic Rhubarb, Rhapontic Rhubarb Root Extract
Overview
Rhapontic Rhubarb Root Extract is derived from the roots of *Rheum rhaponticum*, a plant traditionally used in herbal medicine. It is primarily used to alleviate menopausal symptoms as an alternative to hormone replacement therapy. The extract contains rhaponticin, a stilbene with estrogenic activity, which specifically binds to estrogen receptor beta (ER-β) without activating estrogen receptor alpha (ER-α). This selective binding is believed to reduce menopausal symptoms without the estrogenic side effects associated with hormone replacement therapy. The research is moderately mature, with several clinical trials and systematic reviews available, generally of high quality, supporting its efficacy in reducing menopausal symptoms. It is available in forms such as capsules or tablets containing standardized root extract.
Benefits
Rhapontic Rhubarb Root Extract significantly reduces the severity of menopausal symptoms, as measured by the Menopause Rating Scale (MRS), with a mean difference of -15.12 compared to control groups (p < 0.001). This indicates a clinically significant reduction in menopausal symptoms. It may also improve anxiety and overall well-being in perimenopausal women. The extract is primarily beneficial for perimenopausal and postmenopausal women experiencing climacteric symptoms. Benefits are typically observed within a few weeks of supplementation, making it a relatively quick-acting option for symptom relief. The evidence supporting these benefits comes from well-designed RCTs and meta-analyses.
How it works
Rhapontic Rhubarb Root Extract acts through phytoestrogenic activity, specifically binding to estrogen receptor beta (ER-β) without activating ER-α. This selective binding helps reduce menopausal symptoms without promoting estrogenic side effects. By interacting with the endocrine system, particularly affecting estrogen-regulated pathways, the extract modulates hormonal balance. The primary molecular target is estrogen receptor beta (ER-β). While specific data on absorption and bioavailability are limited, clinical efficacy suggests adequate bioavailability, allowing the active compounds to exert their effects on the targeted receptors.
Side effects
Rhapontic Rhubarb Root Extract is generally considered safe with long-term use, as no significant adverse events have been reported in clinical trials. Common, uncommon, and rare side effects have not been documented in the literature. No significant drug interactions have been reported, but caution is advised with concurrent use of estrogen-sensitive medications. There are no specifically identified contraindications, but caution is advised in individuals with estrogen-sensitive conditions. It is considered safe for use in perimenopausal and postmenopausal women; data on other populations are limited. Individuals with a history of estrogen-sensitive conditions should consult a healthcare provider before use.
Dosage
Standardized extracts, such as ERr 731, are commonly used in clinical trials. While a minimum effective dose has not been specifically defined, continuous supplementation is recommended for sustained benefits. The maximum safe dose has not been established, but long-term use of standardized extracts has been safe in clinical trials. It is typically available as capsules or tablets containing standardized root extract. No specific cofactors are required for absorption. It is essential to use standardized extracts to ensure efficacy and safety. Always follow the manufacturer's recommendations or consult with a healthcare professional for personalized dosage advice.
FAQs
Is Rhapontic Rhubarb Root Extract safe?
It is generally considered safe for long-term use, with no significant adverse events reported in clinical trials. However, individuals with estrogen-sensitive conditions should consult a healthcare provider.
How long does it take to see results?
Significant reduction in menopausal symptoms can be expected within a few weeks of starting supplementation with Rhapontic Rhubarb Root Extract.
Is this a hormone replacement therapy?
No, it is not a hormone replacement therapy. It is a phytoestrogenic supplement that selectively binds to estrogen receptor beta (ER-β) without activating ER-α.
How should I take Rhapontic Rhubarb Root Extract?
Continuous use is recommended for sustained symptom relief. Follow the manufacturer's recommendations for standardized extracts, typically available in capsule or tablet form.
What should I look for when purchasing this supplement?
It is essential to use standardized extracts to ensure both efficacy and safety. Look for products that specify the extract and dosage on the label.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11144934/ – This systematic review and meta-analysis evaluated the efficacy of ERr 731 in reducing menopausal symptoms. The study included four high-quality RCTs with a total of 390 participants, showing a significant reduction in MRS scores (MD: -15.12, p < 0.001). These findings suggest that ERr 731 is effective in alleviating menopausal symptoms.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9144273/ – This article discusses the use of Rhapontic Rhubarb extract as a non-hormonal treatment option for menopausal symptoms. It highlights the phytoestrogenic activity of the extract and its selective binding to estrogen receptor beta. The review suggests that Rhapontic Rhubarb extract can effectively reduce menopausal symptoms without the risks associated with traditional hormone replacement therapy.
- https://pubmed.ncbi.nlm.nih.gov/38646867/ – This study investigates the effects of Rhapontic Rhubarb extract on menopausal symptoms. The research provides evidence supporting the extract's ability to alleviate climacteric complaints and improve the quality of life for perimenopausal women. The findings contribute to the growing body of evidence supporting the use of Rhapontic Rhubarb extract as a safe and effective alternative to hormone therapy.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9964395/ – This research explores the potential benefits of Rhapontic Rhubarb extract for women experiencing menopausal symptoms. The study examines the extract's impact on various aspects of menopausal health, including hot flashes, night sweats, and mood disturbances. The results indicate that Rhapontic Rhubarb extract can provide significant relief from these symptoms, improving overall well-being.
- https://www.semanticscholar.org/paper/Long-term-efficacy-and-safety-of-the-special-ERr-of-Hasper-Ventskovskiy/dbb1b3edc84aab5e52fed725a47fcee38b9a8125 – This study demonstrated the long-term safety and efficacy of ERr 731 in perimenopausal women, with no adverse events reported. A 12-week RCT found that ERr 731 significantly reduced climacteric complaints in perimenopausal women compared to placebo. The research supports the use of ERr 731 as a safe and effective option for managing menopausal symptoms over an extended period.
Supplements Containing Rhapontic Rhubarb Root Extract
Complete Multi-Symptom Menopause Relief
Estroven
Complete Multi-Symptom Menopause Relief
Estroven
Complete Multi-Symptom Menopause Relief
Estroven
Complete Multi-Symptom Menopause Relief
Estroven
Menopause SAP
NFH
Complete Menopause Relief
Estroven
Complete Menopause Relief
Estroven
Complete Menopause Relief
Estroven
Estroven Complete + Ashwagandha
Estroven®