Infusion Of Helianthemum Nummularium
Also known as: Common rock-rose, sunrose, rock rose, Helianthemum nummularium
Overview
Helianthemum nummularium, commonly known as common rock-rose or sunrose, is a perennial shrub native to Europe, typically found in high-altitude environments. The supplement form is usually an infusion or extract derived from its aerial parts, including leaves and flowers. Traditionally, it has been used in herbal medicine and is a component of Bach Flower Remedies, where it is purportedly used for emotional balance and mild psychological conditions. The plant contains various phytochemicals, such as flavonoids (e.g., kaempferol, quercetin derivatives), phenolic acids (e.g., p-hydroxybenzoic acid), and glycosides (e.g., tiliroside, astragalin). While preclinical research suggests potential mechanisms, clinical data on H. nummularium supplementation are limited, with no comprehensive systematic reviews or meta-analyses available to date.
Benefits
Research on *Helianthemum nummularium* is primarily preclinical, with limited evidence for human benefits. The most notable finding is the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway by ethanolic extracts in in vitro studies. This pathway regulates cytoprotective genes and may contribute to cellular defense against oxidative stress, potentially supporting healthy aging. However, this effect has not been demonstrated in human clinical trials. Another in vitro study suggested possible anti-biofilm and corrosion resistance effects on titanium surfaces, which might be relevant for dental or implantology fields, but this does not translate to direct human supplementation benefits. As a component of Bach Flower Remedies, it has been tested for ADHD symptom management, but randomized controlled trials showed no significant benefit over placebo, and these studies had methodological limitations such as small sample sizes and high dropout rates. Currently, there is no robust clinical evidence to support specific benefits in defined human populations.
How it works
The primary proposed mechanism of action for *Helianthemum nummularium* involves the activation of the Nrf2 transcription factor. In vitro studies using ethanolic extracts have shown a dose-dependent activation of Nrf2, which subsequently promotes the expression of genes involved in antioxidant defense and cytoprotection. This suggests a potential role in cellular resilience against oxidative stress. Interestingly, isolated pure compounds from the plant, such as flavonoids and phenolic acids, showed less Nrf2 activation individually, indicating a possible synergistic effect when present in the whole extract. However, detailed pharmacokinetic or bioavailability data for human consumption are currently unavailable, making it difficult to fully understand how these compounds interact with human body systems.
Side effects
There are no clinical safety data or adverse event reports from human trials specifically on *Helianthemum nummularium* supplementation. Traditional use and in vitro studies suggest a low toxicity profile, but the absence of rigorous clinical safety data means that definitive conclusions about its safety cannot be made. No known drug interactions or contraindications have been documented in peer-reviewed literature. Due to the lack of comprehensive clinical research, the severity, frequency, and specific risk factors associated with its use are unknown. Individuals considering its use should be aware of the limited safety information and consult with a healthcare professional, especially if they have underlying health conditions or are taking other medications.
Dosage
Due to the lack of clinical trials, there are no established dosing guidelines for *Helianthemum nummularium* supplementation. Traditional herbal preparations vary widely, and there is no standardization for infusion concentrations or extract potencies. The optimal dosage, timing of administration, and most effective formulation remain undetermined. Without clinical research, it is not possible to specify different dosages for different purposes or to identify upper limits and safety thresholds. Any use of *Helianthemum nummularium* as a supplement should be approached with caution due to the absence of evidence-based dosing recommendations.
FAQs
Is *Helianthemum nummularium* effective for psychological conditions?
Current randomized controlled trial evidence does not support the efficacy of *H. nummularium*, either as a single agent or as part of Bach Flower mixtures, for conditions like ADHD or other psychological problems. Studies have shown no significant benefit over placebo.
Is *Helianthemum nummularium* safe to use?
While no significant safety concerns or adverse effects have been reported in the limited studies available, clinical safety data are insufficient. There is a lack of rigorous human trials to fully assess its safety profile.
How long does it take for effects to appear?
There are no clinical data available to determine the onset or duration of any potential effects from *Helianthemum nummularium* supplementation. Its efficacy and timeline for action remain unestablished.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/32645735/ – This in vitro biochemical study investigated the phytochemical composition and biological activities of *Helianthemum nummularium* extracts. It found that the ethanolic extract dose-dependently activated the Nrf2 pathway, suggesting a potential role in antioxidant defense, although isolated compounds showed less activity. The study provides mechanistic insight but lacks clinical relevance.
- https://ecronicon.net/assets/ecmi/pdf/ECMI-14-00462.pdf – This in vitro electrochemical study explored the effects of a rock rose floral remedy on titanium surfaces. It reported that the remedy reduced corrosion and biofilm formation, indicating potential antimicrobial or protective properties. However, these findings are from an in vitro setting and have low direct clinical relevance for human supplementation.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2695424/ – This randomized controlled trial evaluated Bach Flower Remedies, including *H. nummularium*, for psychological problems and pain, specifically in children with ADHD. The study found no significant difference between the Bach Flower Remedy group and the placebo group, with both showing some improvement. The study had methodological flaws, including a small sample size and high dropout rate, limiting its conclusions.