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Rosa Roxburghii Extract

Q: Is *Rosa roxburghii* safe for long-term use?

Generally considered safe, however, long-term use should be monitored, especially in conjunction with other medications or supplements.

Q: When is the best time to take *Rosa roxburghii*?

Consistent daily intake is recommended; no specific timing has been determined to be optimal.

Q: What benefits can I expect from using this extract?

Expect enhanced antioxidant status, potential relief from ulcerative colitis symptoms, and other health benefits.

Q: Is this a cure for any diseases?

*Rosa roxburghii* is not a cure-all, but it may enhance overall health and provide protection against oxidative stress.

Also known as: Rosa roxburghii, Roxburgh rose, Rosa Roxburghii fruit extract, Rosa roxburghii Extract

Overview

*Rosa roxburghii* is a plant species native to China, notable for its fruit rich in bioactive compounds such as flavonoids, organic acids, triterpenes, and polysaccharides. This extract is valued for its antioxidant, anti-inflammatory, and potential anti-tumor properties, primarily due to its high ascorbic acid (Vitamin C) and polyphenols content. Traditionally used in medicine and dietary supplements, it aims to enhance antioxidant capacity and combat oxidative stress. Studies, primarily in vitro and in vivo, exhibit moderate evidence supporting its bioactivity, with some clinical trials hinting at effectiveness in conditions like ulcerative colitis and cancer. Despite promising findings, the lack of systematic reviews and large clinical trials suggests that more research is essential to confirm its clinical efficacy and safety.

Benefits

The benefits of *Rosa roxburghii* extract are substantial, particularly its significant antioxidant capacity, which has been evidenced by studies showing increased plasma antioxidant levels and improved glutathione redox status. For instance, one study noted relevant improvements with p-values of 0.04 and 0.03. Additionally, the extract protects against oxidative stress, leading to a marked reduction in DNA damage in exposed stem cells (p < 0.0001). Its anti-inflammatory effects include alleviating ulcerative colitis symptoms and reducing inflammation in animal models. Furthermore, *Rosa roxburghii* demonstrates potential anti-tumor properties by inhibiting proliferation in various cancerous cell lines. The most likely beneficiaries are healthy individuals and those suffering from conditions such as ulcerative colitis; however, the clinical significance of these benefits requires further investigation.

How it works

*Rosa roxburghii* extract operates through multiple mechanisms primarily by scavenging free radicals, enhancing antioxidative capacity and protecting cells against oxidative stress. This antioxidant action bolsters cellular defense and mitigates DNA damage. Additionally, the extract interferes with inflammatory pathways, reducing symptoms in conditions like ulcerative colitis, while promoting gastrointestinal health and protecting the colon mucosa. It has been noted to increase telomerase activity and improve the GSH:GSSG ratio, suggesting its role in cellular longevity and antioxidant defense.

Side effects

Literature indicates that *Rosa roxburghii* extract is generally safe with no common side effects reported (>5%) and only rare (<1%) or uncommon (1-5%) effects potentially occurring. No significant drug interactions have been documented, though caution is advised when taken with other antioxidants due to potential synergistic effects. Specific contraindications are not established; however, individuals allergic to rose family plants should take precautions. Pregnant or breastfeeding women should consult healthcare providers before use since the extract's long-term safety and impacts during these stages require further substantiation. Overall, monitoring for adverse reactions is recommended, especially for individuals on multiple medications.

Dosage

The optimal dosing for *Rosa roxburghii* extract is not well-defined, with evidence suggesting a range from 100 μg/mL to several grams per day, contingent on the health outcomes targeted. Due to variability in individual responses and treatment goals, consistent daily use is encouraged to maintained elevated antioxidant status, with no recorded adverse effects associated with high doses so far. Forms of supplementation include extracts, juices, and powders, but the most effective form remains under study. Absorption may be enhanced by co-administration with fatty foods, which could improve bioavailability.