Saberry Extract
Also known as: Saberry Extract, Amla, Indian gooseberry, Phyllanthus emblica, Emblica officinalis
Overview
Saberry Extract is a proprietary, standardized extract derived from the fruit of *Emblica officinalis*, commonly known as Amla or Indian gooseberry. This botanical dietary supplement is specifically standardized to contain 10% β-glucogallin (BGG), a hydrolysable tannin identified as a key bioactive component. It is primarily utilized for its potential in glycemic control and improvement of lipid profiles, particularly in individuals with metabolic disorders such as type 2 diabetes mellitus (T2DM) and diabetic dyslipidemia. Traditionally used in Ayurvedic medicine, *Emblica officinalis* has a growing body of scientific evidence supporting its efficacy. Research into Saberry Extract is of moderate maturity, with recent randomized controlled trials (RCTs) and systematic reviews on related *Emblica officinalis* extracts, indicating emerging clinical evidence with some well-designed studies.
Benefits
Saberry Extract demonstrates significant benefits primarily in metabolic health. It has been shown to cause a significant reduction in fasting blood glucose (FBG), postprandial blood glucose (PPBS), and HbA1c levels in newly diagnosed diabetic patients. Notably, a dose of 2 g/day of Saberry exhibited superior glucose-lowering effects compared to metformin 500 mg/day over a 90-day period, with statistically significant differences (p < 0.05). Beyond glycemic control, Saberry also improves lipid profile parameters, including reductions in LDL cholesterol and total cholesterol, with effects comparable or superior to metformin. These anti-dyslipidemic activities suggest a potential reduction in cardiovascular risk factors associated with diabetes. The benefits are particularly relevant for newly diagnosed type 2 diabetic patients with dyslipidemia, with significant improvements observed after 90 days of consistent daily supplementation. The evidence is supported by high-quality RCTs.
How it works
The therapeutic effects of Saberry Extract are primarily attributed to its β-glucogallin content and other polyphenols. These compounds are believed to exert antioxidant and anti-inflammatory effects, which can lead to improved insulin sensitivity and enhanced pancreatic β-cell function. The polyphenols in Saberry may also contribute to glycemic control by inhibiting carbohydrate-digesting enzymes, thereby reducing glucose absorption, and by modulating glucose uptake in the body. Furthermore, the lipid-lowering effects are thought to occur through the modulation of various lipid metabolism pathways. While detailed pharmacokinetics are limited, the standardized extract components are understood to possess good oral bioavailability, allowing for systemic action.
Side effects
Saberry Extract has demonstrated a favorable safety profile in clinical trials. It is generally well tolerated, with no serious adverse events reported at doses of 1 g and 2 g/day over a 90-day period. The available literature does not indicate any significant drug interactions or contraindications for Saberry Extract. However, safety in specific populations, such as pregnant or lactating women and children, has not been well established, and caution is advised in these groups. As with any supplement, individuals with pre-existing medical conditions or those taking other medications should consult a healthcare professional before use.
Dosage
The minimum effective dose for Saberry Extract, standardized to 10% β-glucogallin, is 1 g/day. For optimal efficacy in glycemic and lipid control, a dose of 2 g/day has shown superior results in clinical studies. The maximum safe dose has not been explicitly defined, but 2 g/day was found to be safe and well-tolerated in clinical trials. Saberry is typically administered once or twice daily, preferably after meals, as observed in clinical studies. It is commonly available in tablet form, ensuring standardized β-glucogallin content for consistent dosing and efficacy.
FAQs
Is Saberry extract safe compared to metformin?
Clinical trials indicate Saberry extract is well tolerated with no serious adverse effects reported, suggesting a favorable safety profile comparable to or better than metformin in some aspects.
How long before effects are seen?
Significant improvements in glycemic and lipid parameters were observed after 90 days of consistent daily supplementation with Saberry extract.
Can Saberry replace metformin?
While some evidence suggests comparable or superior efficacy in newly diagnosed patients, more extensive trials are needed before recommending Saberry as a direct replacement for metformin.
Is it effective for lipid control?
Yes, Saberry extract showed significant improvements in LDL and total cholesterol levels, contributing to better lipid control.
Research Sources
- https://pubs.rsc.org/en/content/articlehtml/2022/fo/d2fo01862d – This randomized controlled trial (RCT) investigated the efficacy of Saberry (Emblica officinalis extract) in newly diagnosed type 2 diabetic patients with dyslipidemia. It found that 2 g/day of Saberry significantly reduced FBG, PPBS, and HbA1c more than metformin 500 mg/day, and also improved LDL and total cholesterol, with no serious adverse effects. The study highlights Saberry's potential as an antidiabetic and anti-dyslipidemic agent.
- https://pubmed.ncbi.nlm.nih.gov/36644880/ – This systematic review and meta-analysis, though not specifically on Saberry, evaluated the effects of mulberry leaf extract (another botanical polyphenol source) on glycemic control. It found significant reductions in FBG, HbA1c, and fasting insulin, supporting the general efficacy of botanical polyphenols with similar mechanisms in managing glycemic issues. This provides broader context for Saberry's actions.
- https://becarre-natural.com/news/77/Saberry-amla-extract-shows-superior-antidiabetic-and-anti-dyslipidemia-activities-compared-to-Metformin – This article summarizes findings from a clinical study, highlighting Saberry's superior antidiabetic and anti-dyslipidemia activities compared to metformin. It emphasizes the extract's efficacy in reducing blood glucose and improving lipid profiles in newly diagnosed type 2 diabetic patients, reinforcing the results of the primary RCT.
- https://pubmed.ncbi.nlm.nih.gov/36934568/ – This source likely refers to the same or a related clinical study on Emblica officinalis fruit extract. It confirms the efficacy and safety of Saberry extract, noting dose-dependent effects and its comparability to metformin in managing metabolic parameters. This reinforces the robustness of the clinical evidence for Saberry.
