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Salidroside

Also known as: Rhodioloside, Salidroside

Overview

Salidroside is a phenylpropanoid glycoside derived from plants such as *Rhodiola rosea*, which has been used in traditional medicine for its potential health benefits. It is primarily noted for its adaptogenic properties and is being researched for its anticancer effects. Key characteristics of salidroside include its antioxidant and anti-inflammatory activities, as well as its ability to induce apoptosis in cancerous cells. Although research on salidroside is expanding, it heavily relies on in vitro and animal studies, and more clinical trials are needed to confirm its efficacy in humans. Currently, it is available mainly in supplement form, such as capsules and tablets.

Benefits

Salidroside is associated with several evidence-based benefits. In laboratory studies, it has been shown to inhibit the proliferation of cancer cells and induce apoptosis, particularly in breast cancer cell lines, with an IC50 of approximately 19.48 μM indicating significant potency in vitro. Additionally, it exhibits strong antioxidant properties by reducing reactive oxygen species (ROS) levels. There may also be neuroprotective effects and an ability to improve stress tolerance, although these claims require further investigation. The strongest potential benefits seem to be for individuals diagnosed with cancer or those seeking antioxidant support, but the overall effect sizes and clinical significance remain unclear due to limited human data.

How it works

Salidroside operates primarily by inducing apoptosis in cancer cells through modulation of key proteins involved in cell survival and death. Specifically, it regulates the balance between Bcl-2 (an anti-apoptotic protein) and Bax (a pro-apoptotic protein) and activates caspases, which are crucial mediators of apoptosis. Additionally, it may influence the MAPK signaling pathway, impacting cellular processes related to the cell cycle and response to stress. While these mechanisms have been identified in experimental settings, specific details about salidroside's absorption and bioavailability in humans are still not well defined.

Side effects

Salidroside is generally regarded as safe based on its traditional use; however, comprehensive safety data from human studies are lacking. Common side effects are not well-documented, and there are no known uncommon or rare adverse effects reported due to insufficient human data. There are potential drug interactions, but these remain under-researched. There are no established contraindications, but caution is advised, particularly in special populations such as pregnant or nursing women, who should consult healthcare professionals before use. Overall, while salidroside is typically safe, further research is necessary to fully assess its safety profile.

Dosage

The optimal dosage of salidroside for humans has not been firmly established. However, typical supplementation ranges from 100 to 200 mg per day based on anecdotal evidence and limited clinical observations. No maximum safe dosage has been determined, and there are no specific recommendations regarding timing for administration. Salidroside supplements are commonly found in capsule or tablet form. Factors affecting absorption are unknown, and no required cofactors have been identified in the literature.

FAQs

Can I take salidroside with other supplements?

Salidroside is often used in combination with other herbal supplements, but its standalone efficacy and safety are not well established.

Is salidroside safe during pregnancy?

Due to limited safety data, pregnant or breastfeeding women should consult healthcare providers before using salidroside.

How long does it take to see results from salidroside?

Expected results may vary; potential antioxidant and anticancer effects require further research to determine concrete timeframes.

Is salidroside a proven cancer treatment?

Salidroside is not a proven treatment for cancer in humans; its effects are mostly supported by laboratory studies.

What should I know before taking salidroside?

While traditionally used safely, salidroside's comprehensive safety profile in humans is still unclear, warranting caution.

Research Sources

https://www.spandidos-publications.com/10.3892/or.2015.3857 – This study investigated the anticancer effects of salidroside on MCF-7 breast cancer cells, highlighting its ability to inhibit cell proliferation and induce apoptosis. Findings indicate significant promise for salidroside's anticancer properties, although the evidence comes from in vitro experiments.
https://pubmed.ncbi.nlm.nih.gov/37934032/ – This report summarizes the biological activities of salidroside, emphasizing its potential as an antioxidant and anti-inflammatory agent. It critically reviews in vitro and in vivo evidence but calls for more human clinical trials to draw definitive conclusions.
https://www.mdpi.com/1424-8247/17/12/1703 – This study discusses various pharmacological effects of salidroside, including growth inhibition in cancer cells and potential neuroprotective benefits. Despite promising results in animal models, it underlines the need for human studies to confirm these effects.
https://pubs.acs.org/doi/10.1021/acs.jafc.3c06672 – The research investigates the antioxidant properties of salidroside, detailing its mechanism of action in reducing oxidative stress. This article emphasizes the broad implications of salidroside for health and wellness, urging further clinical research.