Salvia Miltiorrhiza Root Extract
Also known as: Danshen, Chinese Sage, Red Sage, Salvia miltiorrhiza
Overview
*Salvia miltiorrhiza*, commonly known as Danshen, is a perennial plant native to China and Japan, widely utilized in traditional Chinese medicine (TCM) for its potential health benefits, particularly in cardiovascular and renal health. The root of the plant is the primary medicinal part, and it is rich in bioactive compounds such as tanshinones and salvianolic acids, which are responsible for its therapeutic properties. The extract has gained attention for treating conditions like lower urinary tract symptoms (LUTS), chronic kidney diseases (CKD), and endometriosis, with a moderate level of research backing its efficacy, including clinical trials and meta-analyses. However, the quality of evidence varies, and further large-scale studies are needed to fully understand its benefits and optimal usage.
Benefits
*Salvia miltiorrhiza* has several evidence-based benefits, especially in urological and renal health. A multicenter randomized controlled trial (RCT) demonstrated significant improvements in lower urinary tract symptoms (LUTS) and erectile function in men, with an enhancement in quality of life measured by International Prostate Symptom Scores (IPSS). In patients with chronic kidney disease (CKD), a meta-analysis indicated improved kidney function, with reductions in serum creatinine and blood urea nitrogen and improved glomerular filtration rates. Additionally, some studies indicate its potential role in managing postoperative endometriosis symptoms. Key findings suggest that benefits for LUTS can be observed over a 12-week treatment duration, and effect sizes for CKD interventions range from moderate to large, highlighting its clinical significance.
How it works
*Salvia miltiorrhiza* exerts its therapeutic effects through several biological mechanisms. The primary modes of action include its antioxidant and anti-inflammatory properties, which help mitigate oxidative stress and inflammation, particularly in the kidneys and cardiovascular system. Active compounds, specifically tanshinones and salvianolic acids, enhance blood circulation and improve endothelial function. These compounds also target signaling pathways like transforming growth factor beta 1 (TGF-β1), reducing fibrosis and promoting healthier kidney function. Overall, its beneficial effects are mediated through the modulation of various cellular pathways that lead to improved organ function.
Side effects
Generally, *Salvia miltiorrhiza* is considered safe, with minimal side effects reported across clinical trials. While most studies indicate a lack of significant adverse effects, there are occasional reports of gastrointestinal upset, particularly in sensitive individuals, though precise data on incidence is limited. Rare side effects are not well documented. Caution should be exercised when combining this extract with anticoagulants and antiplatelet medications due to its potential effects on hemostasis. Furthermore, it is advised against use during pregnancy and breastfeeding due to insufficient safety data. Patients with bleeding disorders should also use it with caution. Overall, the safety profile appears favorable, but individual responses can vary.
Dosage
The optimal dosage of *Salvia miltiorrhiza* root extract is not well established, with recommended daily doses commonly ranging from 400 mg to 800 mg based on clinical studies. These dosages have shown efficacy particularly in treating LUTS and improving kidney function in CKD patients. While no maximum safe dose is clearly defined, exceeding typical study doses may elevate risks of side effects due to limited safety data on high-dose usage. The extract is typically formulated as capsules or tablets and is recommended to be taken orally; timing with meals does not appear to significantly impact absorption. Factors such as food intake and individual metabolic differences may influence the bioavailability of its active constituents.
FAQs
When will I see results from taking Salvia miltiorrhiza?
Users may notice benefits within several weeks to months of consistent use, particularly for issues like urinary symptoms and kidney function.
Is Salvia miltiorrhiza safe to take with other medications?
While generally safe, caution is warranted when used alongside anticoagulants or antiplatelet drugs due to potential interactions.
What should I expect in terms of health improvements?
Improvements may include reduced urinary tract symptoms, better erectile function, and enhanced kidney health.
Can Salvia miltiorrhiza cure diseases?
It is not a cure but can serve as a complementary therapy for various conditions when used under professional guidance.
Research Sources
- https://www.mdpi.com/2072-6643/17/1/24 – This study presents a multicenter RCT involving 136 men with LUTS, demonstrating significant improvements in urinary symptoms and erectile function over a 12-week period, asserting the extract's potential in urological health.
- https://pubmed.ncbi.nlm.nih.gov/35250579/ – A meta-analysis involving 2264 CKD patients detailing improvements in kidney function parameters post-treatment with *Salvia miltiorrhiza*, reinforcing its efficacy in managing chronic kidney conditions.
- https://www.sciopen.com/article/10.1016/j.jtcms.2022.09.007 – A systematic review assessing the efficacy of *Salvia miltiorrhiza* in managing postoperative endometriosis, suggesting potential benefits when used alongside GnRH-a.
- https://www.science.gov/topicpages/m/medicine+salacia+oblonga – Overview of herbal medicines with emphasis on *Salvia miltiorrhiza*, highlighting its traditional uses and significant compounds contributing to its pharmacological properties.
- https://onlinelibrary.wiley.com/doi/10.1155/2022/2117433 – This comprehensive review provides insights into *Salvia miltiorrhiza*'s pharmacological effects, supporting its traditional applications and detailing its mechanisms of action.
