Salvia Miltorrhiza Extract
Also known as: Chinese Sage, Red Sage, Danshen, Salvia miltiorrhiza
Overview
*Salvia miltiorrhiza*, commonly known as Danshen, is an herbal supplement widely used in traditional Chinese medicine, predominantly sourced from China. It is particularly noted for its potential therapeutic effects on cardiovascular health and kidney function. The plant contains bioactive compounds such as Salvianolate and Tanshinone, which are believed to exert protective effects in cardiovascular disease (CVD) and chronic kidney disease (CKD). Although research validates some benefits, variability in study quality necessitates further process and efficacy exploration. Various forms of *Salvia miltiorrhiza*, including capsules, tablets, and teas, are available to consumers and practitioners, solidifying its place in herbal medicine disciplines.
Benefits
Research indicates that *Salvia miltiorrhiza* can significantly contribute to cardiovascular health by improving heart functionality in individuals suffering from coronary heart disease (CHD) and heart failure (HF), evidenced through enhanced left ventricular ejection fraction (LVEF) and reduced left ventricular end-diastolic diameter (LVEDD). Additionally, studies confirm benefits for kidney patients, notably in chronic kidney disease (CKD), where extracts reduce serum creatinine levels and elevate glomerular filtration rate (GFR), delaying disease progression. While secondary benefits in managing endometriosis and improving outcomes for women with polycystic ovary syndrome (PCOS) have also been documented, a broader spectrum of robust clinical trials is essential to ascertain these findings conclusively.
How it works
*Salvia miltiorrhiza* predominantly exerts its effects through its key active constituents, Salvianolate and Tanshinone. These compounds are recognized for their antioxidant and anti-inflammatory properties, which contribute to vasodilation and improved blood flow, especially important in cardiovascular health. The richness of these bioactive components allows interaction with multiple biological pathways, including modulation of inflammatory markers and cellular signaling, ultimately improving heart and kidney function. Delineating specific molecular interactions and pharmacokinetics, however, remains a domain requiring further inquiry.
Side effects
The general safety profile of *Salvia miltiorrhiza* indicates it is well-tolerated at recommended doses, with adverse effects akin to those observed in control groups during trials. Reported side effects are frequently mild; gastrointestinal disturbances have been noted but are uncommon. In rare instances, significant adverse effects have not been closely tied to the supplement. Caution is warranted when used alongside anticoagulants and antiplatelet medications due to potential interactions heightened by its own antiplatelet activity. Pregnant and breastfeeding individuals should exercise caution due to a lack of safety data. As with any supplement, patients with bleeding disorders should seek medical advice prior to use.
Dosage
Recommended dosages of *Salvia miltiorrhiza* vary; typically, the effective range is between 1 to 3 grams of dried herb per day. As the minimum effective dose is not concretely established, users should consider individual health conditions when determining dosage. Information regarding maximum safe doses is scant, urging long-term use to be closely monitored. For optimal effects and to minimize gastrointestinal disturbances, consumption alongside meals is advised. Dosage form (capsules, tablets, teas) can influence absorption, and while no specific cofactors are noted as essential for efficacy, individual variances in response are to be expected.
FAQs
Is *Salvia miltiorrhiza* safe for long-term use?
Generally considered safe, but long-term effects are not fully understood. Monitoring is advisable.
Can *Salvia miltiorrhiza* interact with other medications?
Yes, it may interact with anticoagulants and antiplatelet drugs; consultation with a healthcare provider is recommended.
What are the expected benefits for cardiovascular health?
It may improve heart function and reduce heart failure symptoms in patients with coronary heart disease.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/35747383/ – This meta-analysis demonstrated that *Salvia miltiorrhiza* improves kidney function, decreasing serum creatinine and enhancing GFR among 2,264 participants, although the overall certainty of evidence is low.
- https://pubmed.ncbi.nlm.nih.gov/35250579/ – This meta-analysis included 19 studies that highlighted enhancements in LVEF and reductions in LVEDD for coronary heart disease patients with heart failure, illustrating significant improvement but variable quality across studies.
- https://pubmed.ncbi.nlm.nih.gov/34055030/ – This systematic review and meta-analysis involving 390 patients suggested that *Salvia miltiorrhiza* may positively influence reproductive outcomes and metabolic parameters, indicating potential benefits in managing polycystic ovary syndrome.
.png&w=3840&q=75&dpl=dpl_56E4ENPzpiVDQEbNFxPJsEu2h6EZ)