Schizandrae Fructus Extract
Also known as: Schizandra, Wuweizi, Omija, Schisandrae Fructus, Schisandra chinensis
Overview
Schisandra chinensis, also known as Schizandra, Wuweizi, or Omija, is a plant native to East Asia. The fruit, Schisandrae Fructus, is commonly used for its medicinal properties in traditional Chinese medicine. It is known for its anti-inflammatory, antioxidant, and neuroprotective effects. The fruit is rich in lignans, phenolic acids, flavonoids, and other bioactive compounds. Research on Schisandra is moderately mature, with an increasing number of studies exploring its pharmacological effects. However, the quality of available evidence varies, with more in vitro and animal studies than human clinical trials. It is often used to support overall well-being and manage inflammatory conditions.
Benefits
Schisandra chinensis has demonstrated anti-inflammatory and antioxidant effects in various studies. These effects are attributed to its rich composition of bioactive compounds, including lignans, phenolic acids, and flavonoids. Potential benefits for cognitive function and lipid metabolism have also been observed in animal studies. Specifically, Schisandra may benefit individuals with inflammatory conditions or those seeking antioxidant support. However, specific effect sizes are not well-documented in human studies, and the time course of benefits remains unclear. More human clinical trials are needed to confirm these benefits and establish clinical significance.
How it works
Schisandra chinensis exerts its effects through the modulation of inflammatory pathways, such as NF-κB, and the enhancement of antioxidant defenses, including SOD activity. It interacts with the immune, nervous, and cardiovascular systems. Molecular targets include enzymes like cyclooxygenase-2 and inducible nitric oxide synthase. However, the absorption and bioavailability of Schisandra's bioactive compounds in humans are not extensively studied. Further research is needed to fully elucidate the mechanisms of action and optimize its therapeutic applications.
Side effects
Schisandra chinensis is generally considered safe, but human data is limited. Common side effects are not well-documented, but potential gastrointestinal upset has been reported. Rare side effects are not reported. Potential drug interactions exist with blood thinners and diabetes medications. It is contraindicated in pregnancy and breastfeeding due to a lack of safety data. Caution is advised in individuals with bleeding disorders or diabetes. Due to limited human safety data, it is important to consult with a healthcare provider before use, especially if taking other medications.
Dosage
The minimum effective dose of Schisandra chinensis is not established for humans. Optimal dosage ranges are not standardized, as it is typically used in traditional medicine without specific dosing guidelines. The maximum safe dose is also undetermined. Ethanol extracts are commonly used. Absorption factors are not well-studied, and required cofactors have not been identified. Due to the lack of standardized dosing and limited human data, it is crucial to consult with a healthcare provider for appropriate usage guidelines.
FAQs
Should I consult a healthcare provider before using Schisandra?
Yes, consult a healthcare provider before use, especially if you are taking medications or have underlying health conditions, due to potential drug interactions and limited human safety data.
Is Schisandra safe to use?
Schisandra is generally considered safe, but human data is limited. Use with caution, especially if pregnant, breastfeeding, or have bleeding disorders or diabetes.
How should Schisandra be administered?
Administration is not standardized. Ethanol extracts are commonly used, but consult with a healthcare provider for appropriate usage guidelines.
What results can I expect from using Schisandra?
Expected results are variable, depending on the condition being treated. There is no guarantee of universal efficacy, and more human clinical trials are needed.
Research Sources
- https://journals.sagepub.com/doi/full/10.1177/1934578X20970855 – This study investigated the effects of Schisandra chinensis extract on learning and memory in mice with induced disorders. The results indicated that the extract improved cognitive function, possibly due to its antioxidant properties, suggesting potential benefits for neuroprotection.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10408133/ – This review discusses the therapeutic potential of Schisandra chinensis in various health conditions. It highlights the antioxidant, anti-inflammatory, and adaptogenic properties of Schisandra, supporting its traditional use in promoting overall well-being and managing stress-related disorders.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8601940/ – This study explores the protective effects of Schisandra chinensis against oxidative stress and inflammation. The findings suggest that Schisandra can modulate cellular pathways involved in antioxidant defense and inflammatory responses, contributing to its therapeutic potential.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7920717/ – This research investigates the effects of Schisandrae Fructus seed extract on lipid and glucose metabolism in mice. The results indicate potential benefits for improving metabolic parameters, suggesting a role in managing metabolic disorders.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5427464/ – This study examines the anti-inflammatory effects of Schisandrae Fructus ethanol extract in a rat osteoarthritis model. The extract reduced inflammation by suppressing pro-inflammatory cytokines, indicating potential therapeutic benefits for osteoarthritis.
