Scrophularia Ningpoensis Root Extract
Also known as: Scrophularia ningpoensis, Chinese Figwort, Scrophulariae Radix
Overview
Scrophularia ningpoensis is an East Asian herb traditionally used for over 2000 years in Chinese medicine. The roots, known as Scrophulariae Radix, are utilized for their medicinal properties, including heat-clearing, blood-cooling, and Yin-nourishing effects. Modern research has identified its hepatoprotective, anti-inflammatory, and neuroprotective capabilities, primarily backed by in vitro and animal studies. The plant is rich in bioactive compounds, including iridoids, phenolic glycosides, phenolic acids, alkaloids, flavonoids, and triterpenes, which contribute to its therapeutic effects. Evidence regarding its efficacy in humans is still limited, necessitating further clinical investigations to establish its full medicinal potential.
Benefits
The primary evidence supports the hepatoprotective effects of Scrophularia ningpoensis, shown through reductions in liver injury markers like ALT and AST in animal models. Secondary benefits include anti-inflammatory and neuroprotective effects, indicating potential advantages for individuals with liver conditions or systemic inflammation. However, the strength and clinical significance of these effects in human populations remain largely untested. Given the moderate level of research maturity, future human trials are critical to solidify and quantify these benefits.
How it works
Scrophularia ningpoensis operates through multiple biological pathways, including antioxidant and anti-inflammatory pathways, potentially modulating liver metabolism. Although specific molecular targets have not been delineated in human studies, its bioactive compounds may influence various body systems, including hepatic, cardiovascular, and nervous systems. The precise mechanisms of action warrant further investigation to better understand its therapeutic roles.
Side effects
Scrophularia ningpoensis is generally regarded as safe based on traditional uses, but comprehensive human safety data is insufficient. Common side effects are not well documented, with some reports suggesting possible gastrointestinal upset or allergic reactions. There is a potential for interactions with blood thinners and hypoglycemic medications due to its effects on platelets and blood sugar levels. Pregnant and breastfeeding women should avoid this supplement due to a lack of safety data. Individuals with bleeding disorders or diabetes should exercise caution when using this supplement.
Dosage
There is no established minimum effective dose for Scrophularia ningpoensis in human studies. Traditional practices often utilize decoctions or extract forms, but standardized dosing guidelines are not available. The maximum safe dose remains undefined, and referred dosages may vary based on individual health conditions and intended effects. The method of preparation can influence bioavailability, emphasizing the importance of consulting healthcare providers for personalized recommendations.
FAQs
What should I consider before using Scrophularia ningpoensis?
Consult your healthcare provider before use, especially if you are on medications or have health conditions.
Is Scrophularia ningpoensis safe to take?
While traditionally considered safe, comprehensive safety data in humans is lacking, necessitating caution.
How should I take this supplement?
Follow traditional guidelines or consult a healthcare provider for appropriate dosing and timing.
What benefits can I expect?
Potential benefits include liver protection and reduced inflammation, although confirmation through human trials is needed.
Can I use it as a substitute for conventional medicine?
It should not be considered a substitute for medical treatment without strong evidence from human trials.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/33772290/ – This study conducts a systematic review on the phytochemistry and pharmacology of Scrophularia ningpoensis, identifying key bioactive compounds and highlighting hepatoprotective, anti-inflammatory, and neuroprotective effects while noting the predominance of in vitro and animal studies.
- https://watermark.silverchair.com/rgaa036.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA00wggNJBgkqhkiG9w0BBwagggM6MIIDNgIBADCCAy8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMITYfhq-iUF--pzy2AgEQgIIDALbn5MmpH8CzVw40MxX-LpBAWZThBFI0aWbqGOh5P8g49M45QkznJFZp91Fl38vK1CHZdP3e8xvX-8VTO5ZYifvLrcmBXKuDwQ1m-5l15_l25rcE0B36jQXWdkqRPYh4SLCJ5Gac8gEpl194GuaAE_zrzlkU5I4PLXP0cxRXX2MrJ16lTtZhLnlR3KF5TmnFH7kmhnX5kvQcE81Q9qEQArQ06BHmEX4PNAmbQ5crpCmmXPoj-dINU12fK2rTvVuIo5t8II1pdvQd-rVIrg6FNwLzAs5YfCwcHpl2lSYiQghjU2Lsy38kQtsWJA1qabjyttC5w_dUcsR7bXQqvTXmZUiUxqTNdfUz1PhwVDjj4A0nGR3yotGfPpjeBxojS_2uOgONa90FOZ9dr7_k6jbuT-aOiyhJxymoIaEEmEBjvcerfMWUAk55HCuSXI6CN5o00eQI88LAp52GyfFmVS6zgOThQS0NrY9EIKKCVVTLFt4JU736Gika6bu0faBYt1FKKSsUeqiaN5VbGJqVLrJwk2PB1eTpu2Ld_Go-JDOa5XrwN2zPj4NazGoQXtjV5PeV5JdRYfcvKwekdk2i8RTDlH2oYFt-MtYPAkJImCbFHz4aYBHNeiiOK6B9HSDvSTH2xeMyhoDYa8uKyDPcdNxApVAzFywChIsa9C7OdbB2dUywXrCqkVWdUeACTz7PLYUgvjfZZdbRZSnZDiR-MIkBPdYrHCty_CJ7NNOyCIO_cZqN4Q4fmdFdSD7HSsV9v2eWgjeKe-P-HJGHV03r2d5DgVWMTqg-ZR4bZWAkEeKF70MAflCojaLlBA2PR1NrDok1vc-fAOzaWOtBNwAi72dPPjPTcf9wRt4d8ZckNlq0XLLASalBp4a7mFQTOVDyudJxk-dGjQjjXJQvndh8ATUPTQkMWpwIsdIPYmwneP_Z95scfP4TzRjy_hpRKJVPCLvzMzeaTLuwdGhvcg8CN9RZsZi1YSye9pmCsaKcaGkzCUNOoFXrS63lWU7YobJjY3gS7Q – This animal study provides insights into the hepatoprotective effects of Scrophularia ningpoensis extracts, demonstrating significant reductions in liver injury markers among tested groups. The findings highlight its potential therapeutic value, albeit with an emphasis on the need for further human trials to validate efficacy.
- https://www.researchgate.net/publication/349682352_Scrophularia_ningpoensis_Hemsl_a_review_of_its_phytochemistry_pharmacology_quality_control_and_pharmacokinetics – A detailed review focusing on the phytochemistry, pharmacological actions, and quality control measures for Scrophularia ningpoensis. It outlines the current state of research and advocates for improved pharmacokinetic studies to establish clearer dosing guidelines and therapeutic applications.