Scrophularia Root Extract
Also known as: Scrophularia Root, Figwort, Scrophularia ningpoensis
Overview
Scrophularia root, or *Scrophularia ningpoensis*, is a member of the Scrophulariaceae family, commonly used in Traditional Chinese Medicine (TCM) for its various health benefits. It is traditionally utilized for treating conditions such as fever, constipation, and throat infections due to its anti-inflammatory, antipyretic, and diuretic properties. The root contains bioactive compounds, including iridoids and phenylethanoid glycosides, which may contribute to its effects. Although there is interest in its potential applications for metabolic disorders, current research is primarily limited to animal studies and anecdotal evidence from traditional uses, indicating a need for more rigorous human clinical trials to validate its efficacy and safety.
Benefits
Evidence suggests that Scrophularia root may aid in managing hyperthyroidism by lowering T3 and T4 thyroid hormone levels in animal models. Its anti-inflammatory and antioxidant properties have also been reported, though they lack comprehensive human studies to confirm efficacy. No specific population benefits have been established through controlled clinical trials, and documented effect sizes remain unclear. The time course for observable benefits has not been defined due to insufficient human research, highlighting a gap in our understanding of its usefulness in treating various conditions.
How it works
Scrophularia root may affect metabolic pathways associated with unsaturated fatty acids and sphingolipid metabolism. Its influence on thyroid hormone levels suggests a mechanism of action involving the endocrine system, yet specific molecular targets and pathways remain under-researched in human subjects. The potential bioavailability and absorption of its compounds are unknown, warranting further investigation into its pharmacokinetics.
Side effects
While generally considered safe based on traditional use, Scrophularia root lacks comprehensive data on its side effects from human trials. Common side effects are not well-documented, and potential interactions with other medications, specifically those affecting thyroid function, have been speculated. There are no established contraindications, but caution is advised for pregnant or breastfeeding women due to insufficient safety data. Given the limited human data available, the severity and frequency of adverse effects, as well as any rare reactions, remain largely undetermined.
Dosage
There are no established recommended dosages for Scrophularia root in human use. Traditionally, it is consumed as a decoction, but specific dosage is not standardized, and optimal dosage ranges remain unclear. The maximum safe dose and timing considerations have not been determined due to a lack of clinical data. Factors influencing absorption are not well understood, and no required cofactors for its effectiveness have been identified.
FAQs
Is it safe to use Scrophularia root?
While traditionally used, the safety of Scrophularia root in humans has not been established due to limited data.
Can I take Scrophularia root if I have thyroid issues?
Consult a healthcare provider before using Scrophularia root, especially if you have thyroid conditions, due to speculative potential interactions.
What benefits can I expect from Scrophularia root?
Potential benefits are largely speculative, with some evidence suggesting effects on thyroid hormone levels, but human trials are needed for confirmation.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.727735/full – This study explores the effects of Scrophularia root extract on hyperthyroidism in rats, noting reduced T3 and T4 levels. While it offers insights into its potential efficacy, the findings are limited by the animal model used and lack human clinical data.
- https://jmla.pitt.edu/ojs/jmla/article/download/246/1489 – This resource discusses the historical usage of Scrophularia root in TCM for various ailments. Although it outlines traditional applications, it highlights the absence of modern clinical studies to substantiate these uses.
- https://watermark.silverchair.com/rgaa036.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA00wggNJBgkqhkiG9w0BBwagggM6MIIDNgIBADCCAy8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMITYfhq-iUF--pzy2AgEQgIIDALbn5MmpH8CzVw40MxX-LpBAWZThBFI0aWbqGOh5P8g49M45QkznJFZp91Fl38vK1CHZdP3e8xvX-8VTO5ZYifvLrcmBXKuDwQ1m-5l15_l25rcE0B36jQXWdkqRPYh4SLCJ5Gac8gEpl194GuaAE_zrzlkU5I4PLXP0cxRXX2MrJ16lTtZhLnlR3KF5TmnFH7kmhnX5kvQcE81Q9qEQArQ06BHmEX4PNAmbQ5crpCmmXPoj-dINU12fK2rTvVuIo5t8II1pdvQd-rVIrg6FNwLzAs5YfCwcHpl2lSYiQghjU2Lsy38kQtsWJA1qabjyttC5w_dUcsR7bXQqvTXmZUiUxqTNdfUz1PhwVDjj4A0nGR3yotGfPpjeBxojS_2uOgONa90FOZ9dr7_k6jbuT-aOiyhJxymoIaEEmEBjvcerfMWUAk55HCuSXI6CN5o00eQI88LAp52GyfFmVS6zgOThQS0NrY9EIKKCVVTLFt4JU736Gika6bu0faBYt1FKKSsUeqiaN5VbGJqVLrJwk2PB1eTpu2Ld_Go-JDOa5XrwN2zPj4NazGoQXtjV5PeV5JdRYfcvKwekdk2i8RTDlH2oYFt-MtYPAkJImCbFHz4aYBHNeiiOK6B9HSDvSTH2xeMyhoDYa8uKyDPcdNxApVAzFywChIsa9C7OdbB2dUywXrCqkVWdUeACTz7PLYUgvjfZZdbRZSnZDiR-MIkBPdYrHCty_CJ7NNOyCIO_cZqN4Q4fmdFdSD7HSsV9v2eWgjeKe-P-HJGHV03r2d5DgVWMTqg-ZR4bZWAkEeKF70MAflCojaLlBA2PR1NrDok1vc-fAOzaWOtBNwAi72dPPjPTcf9wRt4d8ZckNlq0XLLASalBp4a7mFQTOVDyudJxk-dGjQjjXJQvndh8ATUPTQkMWpwIsdIPYmwneP_Z95scfP4TzRjy_hpRKJVPCLvzMzeaTLuwdGhvcg8CN9RZsZi1YSye9pmCsaKcaGkzCUNOoFXrS63lWU7YobJjY3gS7Q – This metabolomics study examines how Scrophularia root impacts metabolic pathways in animal models, pointing to a potential influence on unsaturated fatty acid and sphingolipid metabolism. However, the lack of human studies hinders conclusions about its relevance for human health.
