Serinaid 50p
Also known as: PS, Serine, Phosphatidylserine
Overview
Phosphatidylserine (PS) is a phospholipid predominantly present in brain tissue, playing a crucial role in maintaining cognitive functions. It is primarily sourced from animal products, particularly brain tissue, and plants such as soybeans. The supplementation of PS is pursued for its potential neuroprotective benefits, including cognitive enhancement, especially among older adults, and its use in managing stress by modulating the body's response to stressors. The available research on PS shows a moderate maturity level, characterized by a combination of strong positive results in some studies alongside inconclusive findings in others, highlighting the need for further investigation on its efficacy and optimal use.
Benefits
Evidence suggests that PS may enhance cognitive function, particularly in older populations experiencing age-related cognitive decline. Specific studies have reported improvements in cognitive performance and reduction in withdrawal/apathy symptoms. Additionally, PS may aid in stress reduction by lowering cortisol levels, particularly among individuals under chronic stress. While some limited research hints at benefits related to exercise performance and mood enhancement, the evidence remains inconsistent. The effect sizes vary, and clinical significance often requires more assessment, making it crucial to consider individual responses. Overall, benefits typically emerge within a few months of supplementation.
How it works
Phosphatidylserine modulates the hypothalamic-pituitary-adrenal (HPA) axis, contributing to stress management by potentially lowering cortisol and adrenocorticotropic hormone (ACTH) levels. It supports neuronal communication and influences neurotransmitter pathways, including dopamine and serotonin, thereby playing a role in cognitive processes. PS is known to cross the blood-brain barrier, enhancing its effectiveness in cognitive functions. By interacting with cell membranes, it contributes to the structural integrity and functionality of neuronal cells.
Side effects
Phosphatidylserine is generally considered safe with few reported side effects. The most common adverse effect is gastrointestinal discomfort, particularly when consumed without food. Other uncommon side effects have not been consistently documented, and no significant rare side effects are known. There is limited information on drug interactions; however, caution is recommended with medications that influence the HPA axis. No well-established contraindications exist, but individuals who are pregnant or breastfeeding are advised to consult healthcare providers before use. Despite its favorable safety profile, the long-term effects of PS supplementation have not been fully studied.
Dosage
The minimum effective dose of phosphatidylserine is approximately 100 mg per day, but a higher dosage of 300 mg is commonly recommended for optimal cognitive benefits. The general dosage range for supplementation is between 200-400 mg per day, with some studies employing higher doses (up to 750 mg/day) in the short term without significant adverse effects. It is suggested to take PS with meals to enhance its absorption and minimize gastrointestinal discomfort. Although no specific forms are preferred, the intake of food is known to support better absorption.
FAQs
Is phosphatidylserine safe to take?
Phosphatidylserine is generally regarded as safe, though it is best taken with food to mitigate any potential gastrointestinal issues.
How long does it take to see results from phosphatidylserine?
Many users may observe cognitive or stress-related benefits within a few months of consistent supplementation.
Can I take phosphatidylserine while on medication?
While minimal interactions are reported, it is advisable to consult with a healthcare provider, especially if on medications that affect the HPA axis.
What should I expect from phosphatidylserine supplementation?
While some individuals may experience improvements in cognitive function and stress management, results can vary significantly among users.
Is phosphatidylserine a cure for cognitive decline?
Phosphatidylserine may support brain health but should not be viewed as a cure for cognitive decline.
Research Sources
- https://cheminutra.com/ingredients/serinaid/ – This source provides an overview of Phosphatidylserine, discussing its cognitive benefits and general usage in supplements, with mentions of evidence supporting its efficacy.
- https://examine.com/supplements/phosphatidylserine/ – Examine.com extensively reviews Phosphatidylserine, highlighting its effects on cognitive function, stress management, and various studies assessing its efficacy in these areas.
- https://pubmed.ncbi.nlm.nih.gov/33539192/ – This PubMed article examines clinical trials assessing the cognitive and stress-related benefits of Phosphatidylserine, noting inconsistencies and areas for further research.
- https://koreascience.kr/article/JAKO202210261444695.page – The research published in Korea Science investigates multiple studies on Phosphatidylserine, discussing its potential roles in cognition and stress, and highlighting gaps in research.