Serinaid 70p
Also known as: PS, phosphatidyl L-serine, Serinaid 70p, Phosphatidylserine
Overview
Phosphatidylserine (PS) is a vital phospholipid molecule, highly concentrated in the cell membranes of the brain, where it plays a crucial role in maintaining neuronal integrity and function. Historically sourced from bovine cortex, modern supplements derive PS from soy or marine sources. It is primarily used as a nutritional supplement for cognitive enhancement, addressing age-related cognitive decline, and managing symptoms of ADHD in children. Research indicates its involvement in neurotransmission and synaptic plasticity, supporting overall brain health. While multiple randomized controlled trials and meta-analyses exist, the overall quality of evidence for its efficacy is considered moderate, with some variability depending on the source and study design.
Benefits
Phosphatidylserine offers several evidence-based benefits, particularly for cognitive function. Meta-analyses suggest that PS supplementation (200-300 mg/day) can improve memory, attention, and language skills in older adults experiencing cognitive decline, with enhanced effects when combined with DHA/EPA. For pediatric ADHD, a meta-analysis of randomized controlled trials found that 200-300 mg/day of PS significantly improved inattention symptoms (effect size 0.36, 95% CI 0.07 to 0.64, p=0.01), though it did not significantly impact hyperactivity or overall ADHD symptoms. Some studies also report mild improvements in motivation and socialization. The benefits are most pronounced in the elderly with subjective memory complaints or mild cognitive impairment, and in children with ADHD. Effect sizes are generally small to moderate (0.3-0.7), and improvements are typically observed after 3-6 months of consistent supplementation.
How it works
Phosphatidylserine primarily functions by supporting the fluidity and structural integrity of neuronal membranes, which is essential for efficient cell signaling. It facilitates the release of neurotransmitters, such as acetylcholine, crucial for learning and memory, and modulates synaptic plasticity, the brain's ability to adapt and form new connections. PS interacts with various body systems, predominantly the central nervous system, specifically impacting cortical and hippocampal neurons. At a molecular level, it influences membrane phospholipids and may interact with acetylcholine pathways and potentially NMDA receptors. Orally administered PS is absorbed and incorporated into cell membranes, with its bioavailability influenced by the source and formulation.
Side effects
Phosphatidylserine is generally well-tolerated, with high-quality randomized controlled trials reporting no serious adverse events. The most common side effects, occurring in over 5% of users, are mild gastrointestinal discomfort, including nausea and flatulence, and occasional dizziness. Less common side effects (1-5%) may include itching or psychomotor agitation, though these are rare and not definitively linked to PS. No clearly established rare side effects have been identified. While no major drug interactions are widely reported, caution is advised when combining PS with anticoagulants due to its phospholipid effects. There are no well-established contraindications, but due to a lack of sufficient data, caution is recommended during pregnancy and lactation. PS has been studied for use in pediatric populations with ADHD and extensively in the elderly with cognitive decline.
Dosage
The minimum effective dose for Phosphatidylserine, based on studies for ADHD and cognitive decline, is approximately 200 mg/day. The optimal dosage appears to be within the range of 200-300 mg/day. Some research suggests enhanced effects when PS is combined with omega-3 fatty acids (DHA/EPA). A maximum safe dose of up to 300 mg/day is generally considered safe, with higher doses not being well-studied. PS should be taken daily, with benefits typically observed after 3 to 6 months of consistent supplementation. Current supplements use marine or soy-derived PS, as bovine cortex-derived PS has been discontinued due to safety concerns. Absorption may be improved when taken with fat-containing meals. Omega-3 fatty acids are considered beneficial cofactors that may synergize with PS.
FAQs
Is Serinaid 70p the same as phosphatidylserine?
Serinaid 70p is a branded form of phosphatidylserine, likely indicating a 70% purity. Clinical data specific to this brand is limited, but its effects are expected to align with general phosphatidylserine research.
Is PS safe for long-term use?
Studies up to 6 months show good safety, but longer-term data are limited. It is generally well-tolerated with mild side effects like gastrointestinal discomfort.
How long does it take to see results from PS supplementation?
Improvements in cognitive function or ADHD symptoms typically become noticeable after several weeks to a few months of consistent daily supplementation, often around 3-6 months.
Does the source of phosphatidylserine matter?
Yes, the source matters. Bovine cortex PS is no longer used due to safety concerns. Modern supplements use soy or marine sources, which are considered safe, though their efficacy may vary slightly.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/33539192/ – This systematic review and meta-analysis by Cortese et al. (2021) investigated the effects of phosphatidylserine (PS) on ADHD symptoms. It found that PS supplementation (200-300 mg/day) significantly improved inattention symptoms in children with ADHD, with an effect size of 0.36. However, it did not show significant effects on hyperactivity or overall ADHD symptoms. The study noted the evidence quality was low due to a small number of studies and heterogeneity.
- https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Phosphatidylserine_(supplement).pdf – This report, citing Kang et al. (2022), summarizes a systematic review and meta-analysis on phosphatidylserine for cognitive decline. It indicates that PS (300 mg/day) improved memory, learning, and motivation in elderly individuals. The review found PS to be safe with mild gastrointestinal side effects. It also highlighted differences in efficacy and safety profiles between bovine-derived and marine/soy-derived PS.
- https://pubmed.ncbi.nlm.nih.gov/36683513/ – This citation points to a study, likely a review or meta-analysis, that supports the use of phosphatidylserine for cognitive function. While the specific details of this study are not fully elaborated in the provided text, it contributes to the overall body of evidence for PS's benefits in memory and learning.
- https://www.webmd.com/vitamins/ai/ingredientmono-992/phosphatidylserine – This WebMD article provides a general overview of phosphatidylserine, including its uses, potential benefits, side effects, and dosage. It serves as a common reference for consumer health information regarding the supplement.
