Serrapeptase 120000 SPU
Also known as: Serrapeptase, Serratiopeptidase, Silk worm enzyme
Overview
Serrapeptase, also known as serratiopeptidase, is a proteolytic enzyme derived from the bacterium *Serratia marcescens*, originally found in silkworms. Commercially produced through fermentation, it is used for its anti-inflammatory, anti-edemic, and analgesic properties. It is often used post-operatively to reduce swelling, and to manage chronic respiratory diseases and pain. Serrapeptase functions by breaking down proteins, reducing inflammation, and aiding in mucus clearance. Research on serrapeptase is considered moderate, with several clinical studies available, though many are limited by small sample sizes or methodological issues. The quality of evidence is mixed, showing some support for specific uses like postoperative swelling, but overall, the evidence is constrained by limitations in study design and execution. Enteric-coated formulations are essential to protect the enzyme from stomach acid.
Benefits
Serrapeptase has demonstrated benefits in reducing postoperative swelling and trismus. A meta-analysis of randomized controlled trials (RCTs) indicated that serrapeptase improved trismus (mean difference: 4.42, 95% CI: 3.84–5.00) following impacted molar removal, although it did not significantly reduce swelling compared to corticosteroids. Additionally, one RCT (n=29) found that serrapeptase reduced mucus production and improved mucus clearance in individuals with chronic bronchitis, but these findings require confirmation through larger studies. While there is potential for pain reduction and anti-inflammatory effects, the evidence supporting these benefits is inconsistent and often of low quality. The benefits of serrapeptase may be more pronounced in individuals with chronic respiratory conditions or those recovering from surgical procedures. The observed effect sizes are modest and primarily seen in specific contexts, such as trismus after dental surgery, with benefits potentially observable within days to weeks, depending on the condition.
How it works
Serrapeptase functions by degrading proteins, including inflammatory mediators and fibrin, which leads to a reduction in inflammation and edema. It interacts with the respiratory, musculoskeletal, and immune systems. Its proteolytic activity targets proteins involved in inflammation and mucus production. Oral bioavailability is low unless the enzyme is enteric-coated, as stomach acid can deactivate it. By breaking down these proteins, serrapeptase helps to alleviate swelling, reduce pain, and promote the clearance of mucus in various conditions.
Side effects
Serrapeptase is generally well-tolerated in clinical studies, with few serious adverse events reported. Common side effects are rare, although gastrointestinal upset is a possibility. Uncommon side effects, occurring in 1-5% of users, may include mild allergic reactions or skin rash. Rare side effects, affecting less than 1% of users, could involve severe allergic reactions or bleeding, the latter being a theoretical risk due to its proteolytic activity. Serrapeptase may increase the risk of bleeding when taken with anticoagulants. There is also a theoretical risk of increased absorption of other drugs due to its proteolytic activity. It is contraindicated in individuals with bleeding disorders or those on anticoagulant therapy. Due to limited data, caution is advised when used during pregnancy, lactation, and in children.
Dosage
The minimum effective dose of serrapeptase is around 10 mg (20,000 SPU) per day, but most studies utilize higher doses. Optimal dosage ranges typically fall between 30–60 mg (60,000–120,000 SPU) per day, depending on the specific condition being treated. The maximum safe dose is not well-established, but doses up to 60 mg/day have been used in studies without significant adverse effects. It is recommended to take serrapeptase on an empty stomach, either at least 30 minutes before eating or two hours after a meal, to maximize absorption. Enteric-coated tablets are recommended to protect the enzyme from stomach acid, which is essential for oral bioavailability. No specific cofactors are identified as required for serrapeptase activity.
FAQs
Why is enteric coating important for serrapeptase?
Enteric coating protects serrapeptase from stomach acid, ensuring it reaches the small intestine where it can be absorbed and exert its effects. Without it, the enzyme may be deactivated in the stomach.
When is the best time to take serrapeptase?
Serrapeptase is best taken on an empty stomach, either 30 minutes before a meal or two hours after eating, to maximize its absorption and effectiveness.
Who should avoid taking serrapeptase?
Individuals with bleeding disorders or those taking anticoagulant medications should avoid serrapeptase due to the potential for increased bleeding risk. Consult a healthcare provider before use.
What benefits can I expect from taking serrapeptase?
Serrapeptase may provide modest improvements in inflammation, swelling, and mucus clearance, particularly in specific contexts like postoperative recovery or chronic respiratory conditions. Results can vary.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/23380245/ – This systematic review examined the clinical applications of serrapeptase, finding mixed evidence for its anti-inflammatory, anti-edemic, and analgesic effects. The review highlighted that many studies had methodological weaknesses, small sample sizes, and lacked standardized dosing, leading to an overall low to moderate quality of evidence.
- https://www.healthline.com/nutrition/serrapeptase – This article provides an overview of serrapeptase, including its potential benefits, side effects, and dosage recommendations. It notes that while serrapeptase may have anti-inflammatory properties and help with pain relief, more high-quality research is needed to confirm these effects.
- https://www.drugs.com/npp/serrapeptase.html – This resource offers information on serrapeptase, including its uses, safety, and potential interactions. It advises caution in individuals with bleeding disorders or those taking anticoagulant medications due to the potential for increased bleeding risk.
- https://www.iherb.com/blog/serrapeptase-guide/1002 – This blog post provides a guide to serrapeptase, covering its benefits, dosage, and how to choose a quality supplement. It emphasizes the importance of enteric-coated formulations for optimal absorption and effectiveness.
- https://pubmed.ncbi.nlm.nih.gov/29618875/ – This meta-analysis of RCTs focused on the use of serratiopeptidase after impacted molar removal, revealing that it improved trismus but did not significantly reduce swelling compared to corticosteroids. The study acknowledges limitations such as the small number of studies and heterogeneity among them.