Get Your Personalized Supplement StackSupplement Stack Quiz

Siberian Root Extract

Also known as: Eleutherococcus senticosus, Siberian Ginseng, Ciwujia, Acanthopanax senticosus

Overview

Eleutherococcus senticosus, commonly known as Siberian Ginseng, is a plant native to Northeastern Asia. While not a true ginseng, it's classified as an adaptogen, believed to aid the body in adapting to stress and promoting overall well-being. The root is primarily used for medicinal purposes, containing eleutherosides, thought to be responsible for its adaptogenic properties. It's used to enhance physical performance, reduce fatigue, improve mental clarity, and boost the immune system. Research on Siberian Ginseng is moderately mature, with several clinical trials and animal studies, but more high-quality research is needed to fully understand its effects. Available evidence varies in quality, with some studies showing promising results, but there is significant heterogeneity in study designs, sample sizes, and outcomes measured. It is available in various forms, including capsules, tablets, and liquid extracts.

Benefits

Siberian Ginseng has shown potential benefits in several areas. A systematic review and meta-analysis indicated that it significantly reduces fatigue compared to a placebo. Studies also suggest it can improve physical performance by reducing blood lactate levels and increasing swimming time in animal models. Some research points to immunomodulatory effects, though the evidence is less robust. Limited but promising evidence suggests it may improve cognitive function, but more research is needed. It may be particularly beneficial for athletes and individuals with high physical demands, as well as those under stress. The time course of benefits can vary, but improvements in fatigue and physical performance are typically observed within a few weeks of consistent use. Effect sizes vary across studies, but significant reductions in fatigue and improvements in physical performance have been observed with moderate to large effect sizes.

How it works

Siberian Ginseng is believed to act through multiple pathways. It influences the body's stress response system, potentially modulating the hypothalamic-pituitary-adrenal (HPA) axis, which is central to the body's response to stress. It has also been shown to increase levels of antioxidants such as glutathione peroxidase and superoxide dismutase, contributing to its adaptogenic effects. Furthermore, it may affect the immune system by influencing cytokine production and immune cell activity. It interacts with the nervous, immune, and endocrine systems. The eleutherosides present in Siberian Ginseng are thought to be the primary active compounds, though the exact molecular targets are not fully elucidated. The bioavailability of eleutherosides is relatively high, but specific data on absorption rates and bioavailability are limited.

Side effects

Siberian Ginseng is generally considered safe when used as directed. Common side effects are not consistently reported across studies. Mild gastrointestinal symptoms, such as nausea and diarrhea, have been reported in some cases. There are no well-documented rare side effects, but as with any supplement, individual reactions can occur. Potential interactions with blood thinners and diabetes medications have been suggested, though more research is needed to confirm these interactions. It is contraindicated in pregnancy and breastfeeding due to a lack of sufficient safety data. Individuals with autoimmune diseases should use caution due to its immunomodulatory effects. It's important to consult with a healthcare provider before starting Siberian Ginseng, especially if you have underlying health conditions or are taking other medications.

Dosage

The typical minimum effective dose is 400-800 mg per day of a standardized extract containing 1-2% eleutherosides. Optimal dosage ranges from 400-1200 mg per day, though optimal dosing can vary based on individual needs and specific formulations. There is no established maximum safe dose, but doses above 1200 mg per day are not well-studied. It can be taken at any time of day, but taking it in the morning may help with energy and alertness. Capsules or tablets containing a standardized extract are common. Bioavailability may be enhanced when taken with a meal. No specific required cofactors have been identified. It is important to start with a lower dose and gradually increase it to assess tolerance.

FAQs

Is Siberian Ginseng safe?

Generally safe, but individuals with certain health conditions or taking specific medications should consult a healthcare provider before use.

When should I take Siberian Ginseng?

It can be taken at any time, but morning use is common for energy and alertness. Consistency is key for observing potential benefits.

How long before I see results?

Improvements in fatigue and physical performance may be observed within a few weeks of consistent use, but individual results may vary.

Is Siberian Ginseng the same as Panax Ginseng?

No, it is not a true ginseng and its effects may vary from those of Panax ginseng. They have different active compounds.

Are there any side effects?

Side effects are rare, but mild gastrointestinal symptoms have been reported. Discontinue use if you experience any adverse reactions.

Research Sources

https://diabetesjournals.org/care/article/26/4/1277/23631/Systematic-Review-of-Herbs-and-Dietary-Supplements – This systematic review examines the effects of various herbs and dietary supplements on diabetes management. While Siberian Ginseng is not the primary focus, the review provides a broader context for understanding the potential role of herbal supplements in managing related health conditions. It highlights the need for rigorous research to validate the efficacy and safety of these supplements.
https://www.cir-safety.org/sites/default/files/Ginsen092012rep.pdf – This report assesses the safety of various ginseng extracts in cosmetic products. Although it primarily focuses on topical applications, it provides valuable information on the potential toxicity and allergenic properties of ginseng compounds. The report concludes that ginseng extracts are generally safe for use in cosmetics at specified concentrations.
https://libguides.mq.edu.au/systematic_reviews/databases – This resource provides guidance on conducting systematic reviews and meta-analyses, including information on relevant databases and search strategies. It is a valuable tool for researchers seeking to synthesize evidence on the efficacy and safety of Siberian Ginseng and other supplements. The guide emphasizes the importance of rigorous methodology to minimize bias and ensure the reliability of findings.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.01031/full – This study investigates the pharmacological effects of Siberian Ginseng, focusing on its adaptogenic and immunomodulatory properties. The research highlights the potential of Siberian Ginseng to enhance the body's resilience to stress and improve immune function. It provides insights into the underlying mechanisms of action and supports the use of Siberian Ginseng as a complementary therapy for various health conditions.
https://www.ajog.org/article/S0002-9378(03)00356-9/abstract – This article discusses the use of herbal therapies during pregnancy. It advises caution regarding the use of Siberian Ginseng during pregnancy due to insufficient safety data. The article underscores the importance of consulting with a healthcare provider before using any herbal supplements during pregnancy to minimize potential risks to the mother and fetus.