Sinetrol Xpur C1
Also known as: Sinetrol-XPur, citrus polyphenol extract, Sinetrol Xpur C1
Overview
Sinetrol Xpur C1 is a proprietary, standardized polyphenolic citrus extract blend derived from the peels of various citrus fruits, including oranges, grapefruits, and blood oranges. It is rich in bioactive citrus flavonoids such as naringin, hesperidin, and polymethoxylated flavones. Primarily marketed and studied as a dietary supplement ingredient for weight management, Sinetrol Xpur C1 is purported to aid in fat loss, particularly abdominal fat, and improve metabolic health. Its mechanism involves promoting lipolysis (fat breakdown) and increasing resting energy expenditure. Additionally, it exhibits antioxidant and anti-inflammatory properties, contributing to overall metabolic well-being. While several randomized controlled trials support its efficacy, independent systematic reviews or meta-analyses specifically on Sinetrol Xpur C1 are limited, indicating a moderate level of research maturity.
Benefits
Sinetrol Xpur C1 has demonstrated several evidence-based benefits, primarily in the realm of weight management and metabolic health. The most significant benefit is a reduction in body weight, waist circumference, hip circumference, and abdominal fat. Clinical trials show a notable decrease in waist circumference (approx. 5.7%) and abdominal fat (approx. 9.7%) after 12 weeks of supplementation in overweight adults, with 100% of the weight loss attributed to fat mass, especially central/trunk fat. It also improves metabolic rate and resting energy expenditure, contributing to fat loss. Secondary benefits include a reduction in inflammatory markers like C-reactive protein (-22.9%) and fibrinogen (-19.9%), and a decrease in oxidative stress markers (malondialdehyde reduced by 14%), alongside an increase in antioxidant enzymes. These effects are particularly relevant for overweight and obese adults, including Asian populations, with observed weight loss of 1.35–2.4 kg over 12 weeks, which is clinically significant for metabolic health.
How it works
Sinetrol Xpur C1 primarily works by promoting lipolysis, the breakdown of stored fat in adipose tissue, and by increasing resting energy expenditure. The polyphenols within the extract are believed to modulate enzymes involved in lipid metabolism, thereby facilitating fat release from adipocytes. Beyond its direct effects on fat metabolism, Sinetrol Xpur C1 also exerts antioxidant and anti-inflammatory effects. These properties help reduce oxidative stress and systemic inflammation, which are often associated with metabolic dysfunction and obesity. The extract's bioactive compounds interact with various body systems, particularly adipose tissue and muscle metabolism, and influence systemic inflammatory pathways, contributing to improved body composition and overall metabolic health.
Side effects
Sinetrol Xpur C1 is generally well-tolerated, with no significant adverse effects reported in clinical trials lasting up to 12 weeks. Common, uncommon, or rare side effects have not been documented in available randomized controlled trials. While no specific drug interactions have been formally documented, caution is advised as citrus flavonoids can theoretically affect cytochrome P450 enzymes, which are involved in the metabolism of many medications. Individuals with known citrus allergies should exercise caution. Contraindications are not explicitly stated, but its safety has not been established in special populations such as pregnant or lactating women, children, or individuals with severe comorbidities. Therefore, these groups should avoid use unless under medical supervision.
Dosage
The recommended and clinically effective dosage for Sinetrol Xpur C1 is 900 mg per day. This dosage has been consistently used in clinical studies, typically administered as two 450 mg capsules. For optimal absorption and efficacy, it is generally recommended to take the supplement twice daily with meals. While a minimum effective dose of 900 mg/day for 12 weeks has demonstrated significant results, a maximum safe dose has not been clearly established, as studies have not reported toxicity at the tested dosages. Sinetrol Xpur C1 is typically available in capsule or tablet form, standardized to its polyphenol content. No specific cofactors are identified as necessary for its absorption or efficacy.
FAQs
Is Sinetrol Xpur C1 safe for long-term use?
Long-term safety data beyond 12–20 weeks is limited. While short-term use appears safe and well-tolerated, more research is needed to confirm its safety over extended periods.
How quickly can weight loss be expected?
Significant reductions in body fat and weight, along with improvements in waist and hip circumference, are typically observed after 12 weeks of consistent daily supplementation.
Does it work without diet or exercise?
While studies show benefits, they often include controlled conditions. The efficacy of Sinetrol Xpur C1 is likely enhanced when combined with a balanced diet and regular exercise.
Are there any side effects?
Clinical trials have reported no significant or common side effects. It is generally considered well-tolerated, but individuals with citrus allergies should be cautious.
Is it effective in all populations?
Evidence primarily supports its efficacy in overweight and obese adults, including Asian populations. Its effects in other demographic groups are less studied.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/23554029/ – This randomized, double-blind, placebo-controlled trial investigated the efficacy of Sinetrol Xpur C1 in 95 overweight adults over 12 weeks. It found significant reductions in waist and hip circumference, abdominal fat, and improvements in inflammatory and oxidative stress markers, with no reported adverse effects. The study supports Sinetrol's role in body composition improvement.
- https://www.nutraingredients.com/Article/2020/04/24/Citrus-extract-may-aid-weight-management-study-finds/ – This article summarizes findings from a randomized, double-blind, placebo-controlled trial involving 86 overweight Korean adults. The study reported that Sinetrol Xpur C1 led to a significant decrease in body weight (1.81%), BMI (2.32%), and fat mass compared to placebo over 12 weeks, indicating its potential for weight management in Asian populations.
- https://www.fytexia.com/en/health-areas/metabolism-body-composition/fat-loss-for-the-long-term-sinetrol/ – This source provides a summary of clinical data on Sinetrol, including studies in both Caucasian and Asian populations. It highlights findings such as fat mass reduction, increased metabolic rate, and a significant proportion of fat loss occurring from the trunk area, contributing to improved body composition. While a summary, it points to consistent efficacy across different groups.
- https://www.clinicaltrials.gov/study/NCT03823196?term=PAULLINIA+CUPANA+SEED&rank=2 – This entry from ClinicalTrials.gov provides details for a study related to a different ingredient (Paullinia Cupana Seed), not Sinetrol Xpur C1. Therefore, it is not directly relevant to the research on Sinetrol Xpur C1 and its findings are not summarized here.
- https://www.semanticscholar.org/paper/Clinical-Study-to-Assess-the-Efficacy-and-Safety-of-Dallas-Gerbi/d84af51c620f1d2542c8322525cf365295de1a30 – This link points to the same study as the first PubMed link (Gerbi et al. 2013). It describes a clinical study assessing the efficacy and safety of Sinetrol Xpur C1, confirming its positive effects on body composition parameters like waist/hip circumference and abdominal fat, along with beneficial impacts on inflammatory and oxidative markers, with a good safety profile.
