Siphoviridae LL5
Also known as: Siphoviridae LL5
Overview
Siphoviridae LL5 is a bacteriophage, a virus that naturally infects bacteria, and is a member of the Siphoviridae family. It is used in dietary supplements to modulate gut microbiota, selectively targeting and eliminating detrimental bacteria while potentially enhancing beneficial microbial populations. Research is emerging, with studies indicating safety and potential benefits in modulating gut microbiota. The quality of available evidence is moderate, with some randomized controlled trials (RCTs) but limited systematic reviews or meta-analyses.
Benefits
Studies suggest that Siphoviridae LL5, as part of a phage cocktail, can reduce *E. coli* populations and improve gastrointestinal symptoms. It may also increase beneficial bacteria like *Eubacterium* and reduce pro-inflammatory cytokines. Potential benefits exist for individuals with gastrointestinal distress or those seeking to modulate their gut microbiota. Improvements in gastrointestinal symptoms have been reported within a few weeks of supplementation.
How it works
Siphoviridae LL5 targets specific bacterial receptors, leading to the lysis of targeted bacteria. It modulates gut microbiota composition, potentially influencing intestinal health and inflammation. The specific bacterial cell wall components are the known molecular targets. Phages are generally thought to be stable in the gastrointestinal tract.
Side effects
Generally considered safe and well-tolerated in human studies. No specific side effects are documented for Siphoviridae LL5 alone, but gastrointestinal symptoms may improve or remain unchanged. No uncommon or rare side effects have been reported in available literature. There are no known drug interactions, but caution is advised with concurrent antibiotic use. No contraindications have been specifically identified. Pregnant or immunocompromised individuals should consult healthcare providers before use.
Dosage
Typically part of a cocktail with other phages, dosed at approximately 10^6 PFU per capsule. Optimal dosage ranges are not well-established, but it is commonly used in combination with other phages. The maximum safe dose is not defined, but high doses have been used without adverse effects. Daily supplementation is common, typically in capsule form. Stability in the gastrointestinal tract is crucial.
FAQs
Is Siphoviridae LL5 safe?
Generally safe, but consult a healthcare provider if immunocompromised or pregnant. Caution is advised with concurrent antibiotic use.
How should I take Siphoviridae LL5?
Typically taken once daily as part of a phage cocktail. Follow the specific product's instructions.
What results can I expect?
Potential improvement in gastrointestinal health, including reduced *E. coli* populations and increased beneficial bacteria.
Can Siphoviridae LL5 replace my medication?
It is not a replacement for medical treatment. Consult a healthcare provider for chronic conditions.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/30157383/ – This RCT assessed the safety and tolerability of a phage cocktail including Siphoviridae LL5 in healthy adults with gastrointestinal distress. The study found the cocktail to be safe and tolerable, with improvements in gastrointestinal symptoms, suggesting a potential benefit for gut health.
- https://www.mdpi.com/2072-6643/12/8/2474 – This study examined the effects of combining probiotics with phages (including Siphoviridae LL5) on gut health. The research found reductions in *Citrobacter* and *Desulfovibrio*, which are associated with inflammation, indicating a potential mechanism for improving gut health.
- https://www.mdpi.com/2076-2607/8/9/1420 – This RCT showed that a phage cocktail including Siphoviridae LL5 reduced *E. coli* and increased beneficial bacteria like *Eubacterium*, with potential anti-inflammatory effects. The findings suggest that the phage cocktail can positively modulate gut microbiota composition.
- https://www.nutraingredients-usa.com/Article/2019/04/02/Phage-cocktail-shows-gut-microbiota-benefits-Deerland-RCT-data/ – This article reports on an RCT demonstrating that a phage cocktail, including Siphoviridae LL5, shows gut microbiota benefits. The data indicates a reduction in *E. coli* and an increase in beneficial bacteria, supporting the potential of phage cocktails for improving gut health.
- https://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.3001424 – This is a general article about bacteriophages. It provides background information on the role and function of bacteriophages in biological systems.
