Slendesta Potato Protein Extract
Also known as: Slendesta® Potato Extract, Potato Protein Extract, Potato Protease Inhibitor II (PI2), Slendesta Potato Protein Extract
Overview
Slendesta® Potato Extract is a standardized extract from the common potato (*Solanum tuberosum*), primarily composed of proteinase inhibitor II (PI2) at a concentration of 5%. This extract is marketed for weight management and appetite suppression, operating through the mechanism of enhancing the release of cholecystokinin (CCK), a hormone that promotes satiety and delays gastric emptying. While the extract shows promising results from animal studies regarding weight reduction and anti-diabetic effects, human research remains limited. Current evidence suggests that while animal studies show significant outcomes, results in humans do not support effective weight loss, highlighting the need for further investigation to validate these claims. The extraction process typically results in a powder form, which is used in various formulations targeting weight management.
Benefits
The benefits of Slendesta® Potato Extract, particularly reported in animal studies, include a significant reduction in body weight, food intake, and fat stores in obese mice, with noted dosages leading to dose-dependent results. Additionally, it may exert anti-diabetic effects indicated by favorable changes in insulin and lipid profiles. However, human studies have thus far failed to establish any clear connection between the use of this extract and significant weight loss, leaving the clinical significance of its effects in humans uncertain. Secondary benefits include potential antioxidant properties and anti-adipogenic effects; again, these are based on in vitro studies needing confirmation through clinical trials. Overall, while there is strong evidence from animal trials, human efficacy remains largely unsubstantiated.
How it works
Slendesta® Potato Extract functions primarily through the action of proteinase inhibitor II (PI2), which triggers the release of cholecystokinin (CCK) in the gastrointestinal tract. CCK is a hormone that promotes feelings of fullness and reduces hunger by delaying gastric emptying. The interaction of PI2 with digestive enzymes potentially influences body systems that regulate appetite and satiety. While the exact absorption and bioavailability of PI2 in humans are yet to be extensively studied, animal research indicates a likely effective mechanism for appetite regulation.
Side effects
The safety profile of Slendesta® Potato Extract appears favorable based on current animal studies; however, human data is minimal and inconclusive. There is no documented evidence of common, uncommon, or rare side effects stemming from human trials, and due to the dearth of rigorous clinical data, the occurrence of side effects cannot be accurately assessed. Furthermore, the impact of interactions with other substances or medications is not well understood, and the extract has not been studied for use across special populations such as pregnant women or children. Caution is advised, and users should consult with healthcare professionals before use in populations with specific health considerations, due to the undefined safety axiom in long-term or high-dose applications.
Dosage
Dosing guidelines for Slendesta® Potato Extract in humans have not been established. Animal studies indicate that a minimum effective dose is as low as 50 mg/kg, but optimal and maximum dosages for human consumption are unclear. The literature lacks robust recommendations regarding the timing of administration, and the form of the extract is commonly found in powder. As such, any derived doses should be approached cautiously, and ongoing consultation with health professionals is advised to establish individual safety protocols.
FAQs
Is Slendesta® Potato Extract effective for weight loss?
Currently, evidence does not support the efficacy of Slendesta® Potato Extract for weight loss in humans, as studies have not demonstrated significant reductions in body weight.
Are there any known side effects?
There is limited human data on side effects, making it difficult to ascertain safety in that population, although animal studies have shown no significant adverse effects.
How should it be taken?
There are no specific guidelines regarding timing or administration of Slendesta® Potato Extract, so consulting a healthcare provider is advisable.
What results can be expected?
Due to insufficient evidence, significant weight loss should not be expected from Slendesta® Potato Extract.
Is it safe to use?
While generally considered safe in animal studies, human safety is not well-established, and consulting with a healthcare professional is recommended.
Research Sources
- https://www.efsa.europa.eu/en/efsajournal/pub/3083 – The EFSA's scientific opinion review highlighted that there is no established cause-and-effect relationship between Slendesta® Potato Extract consumption and body weight reduction, based on a review of multiple human intervention studies.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4906612/ – This study presented findings on the anti-obesity and anti-diabetic effects of Slendesta® Potato Extract in *ob/ob* mice, illustrating significant weight and adipose tissue reductions at varying dosages over a 28-day period.
- http://www.bioline.org.br/pdf?tc16043 – In an in vitro investigation, the extract was shown to inhibit preadipocyte differentiation and demonstrated antioxidant properties, although the applicability of these results to human physiology remains limited.
- https://pubmed.ncbi.nlm.nih.gov/27347062/ – A comprehensive study elucidated the mechanisms by which Slendesta® Potato Extract affects weight management, focusing on the proteinase inhibitor II (PI2) and its role in appetite regulation.
- https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2013.3083 – This research review reiterated the insufficiency of evidence from human studies to support claims regarding the effectiveness of Slendesta® Potato Extract in weight loss, reinforcing the need for more comprehensive research.
