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Multi-Peptide + HA Serum

Also known as: Multi-Peptide + HA Serum, peptides, hyaluronic acid, SYN™-AKE, Matrixyl™ synthe'6™, Matrixyl™ 3000, ARGIRELOX™, acetyl hexapeptide-8, palmitoyl tripeptide-38, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, sodium hyaluronate crosspolymer

Overview

The Multi-Peptide + HA Serum is a topical cosmetic formulation designed to address signs of skin aging. It combines several synthetic peptides, including SYN™-AKE, Matrixyl™ synthe'6™, Matrixyl™ 3000, and ARGIRELOX™, with various hyaluronic acid complexes. Peptides are short chains of amino acids that act as signaling molecules to stimulate skin repair and collagen synthesis, while hyaluronic acid, a naturally occurring glycosaminoglycan, provides intense hydration and plumping effects. This serum aims to reduce the appearance of fine lines and wrinkles, improve skin elasticity and firmness, and enhance overall skin texture and hydration. It is formulated to be vegan, cruelty-free, and free from common irritants like alcohol, silicones, parabens, and fragrances, with a skin-friendly pH of 4.5–5.5. While individual components are well-researched, the specific combination in this serum has a moderate level of research maturity, with promising but limited independent clinical trials.

Benefits

The Multi-Peptide + HA Serum offers several evidence-based benefits for skin health. A 12-week randomized, double-blind, placebo-controlled study involving 56 female subjects aged 35–60 demonstrated statistically significant improvements in expression lines, wrinkles, and overall skin health with a peptide serum, suggesting similar efficacy for this product. Specifically, it helps reduce the appearance of crow’s feet wrinkles, improves skin smoothness and texture, and enhances skin elasticity and firmness. Beyond wrinkle reduction, the hyaluronic acid complexes in the serum significantly improve skin hydration and reduce trans-epidermal water loss (TEWL). Crosslinked sodium hyaluronate, a component of the serum, has been shown to reduce TEWL by approximately 27.8%, outperforming other forms of HA. These benefits are particularly applicable to middle-aged women with mild-to-moderate facial wrinkles and individuals concerned with early signs of skin aging. Noticeable improvements are typically observed after 12 weeks of consistent use.

How it works

The Multi-Peptide + HA Serum works through a dual mechanism involving both peptides and hyaluronic acid. Peptides function as signaling molecules that stimulate key cellular processes in the skin. For instance, Matrixyl™ peptides promote collagen synthesis and extracellular matrix remodeling, leading to improved skin structure and firmness. ARGIRELOX™ (acetyl hexapeptide-8) and SYN™-AKE mimic the effects of muscle relaxants by inhibiting neurotransmitter release or muscle contraction, thereby reducing the appearance of expression lines. Concurrently, hyaluronic acid complexes hydrate the skin by attracting and retaining water molecules, which plumps the skin, improves turgor, and strengthens the skin's natural barrier function. The varied molecular weights of HA complexes ensure hydration at different skin depths and reduce trans-epidermal water loss, contributing to overall skin health and a smoother appearance.

Side effects

The Multi-Peptide + HA Serum is generally considered safe and well-tolerated for topical use. Clinical studies referenced have not reported any common (over 5%), uncommon (1-5%), or rare (under 1%) side effects. This favorable safety profile is attributed to its formulation, which is free from common irritants such as alcohol, silicones, parabens, and fragrances. There are no known drug interactions specifically associated with the topical application of these peptides and hyaluronic acid. However, as with any skincare product, individuals with known hypersensitivity or allergies to any of the ingredients should avoid its use. While no adverse effects have been reported in general use, safety in pregnant or nursing women has not been definitively established, as these populations were excluded from the primary clinical study. Therefore, caution is advised for pregnant or nursing individuals. Overall, the serum presents a low risk of adverse reactions when used as directed.

Dosage

For optimal results, the Multi-Peptide + HA Serum should be applied topically once or twice daily. While a minimum effective dose is not explicitly established, clinical studies demonstrating efficacy involved consistent daily application over a 12-week period. The serum formulation is designed to enhance the stability and skin penetration of the peptides and hyaluronic acid complexes. There is no established maximum safe dose for topical application, as the product is generally well-tolerated within recommended usage amounts. Consistent daily use is crucial, as visible benefits typically appear after approximately 12 weeks. The inclusion of multiple hyaluronic acid complexes with varying molecular weights ensures comprehensive hydration and absorption. No specific cofactors are required for the serum's efficacy, as its formulation already includes supporting amino acids and moisturizing agents.

FAQs

Is the serum effective for advanced wrinkles?

The serum is primarily targeted for early signs of aging. For more advanced wrinkles, formulations with additional ingredients like copper peptides or more intensive treatments may be recommended.

Is it safe for sensitive skin?

Yes, the serum is formulated without common irritants such as alcohol, silicones, parabens, and fragrances, making it generally well-tolerated for sensitive skin types.

How soon will results appear?

Clinical evidence suggests that noticeable improvements in skin health and wrinkle reduction typically appear after approximately 12 weeks of consistent, regular use.

Can it be combined with other skincare products?

Generally, yes. However, it's advisable to avoid combining it with strong exfoliants or other highly active ingredients that might increase skin sensitivity.

Does hyaluronic acid hydrate from the outside?

Yes, topical hyaluronic acid primarily hydrates by forming a moisture barrier on the skin's surface and retaining water, rather than penetrating deeply into the skin layers.

Research Sources

https://jcadonline.com/efficacy-tolerability-peptide-serum/ – This randomized, double-blind, placebo-controlled clinical study, involving 56 female subjects aged 35-60 over 12 weeks, found that a peptide serum significantly improved expression lines, wrinkles, and overall skin health compared to a placebo. The study supports the efficacy of peptide-based serums for anti-aging, though it had a small sample size and did not detail exact effect sizes.
https://onlinelibrary.wiley.com/doi/10.1111/jocd.15849 – This comparative research from 2016 investigated the effects of different hyaluronic acid molecular weights on skin hydration. It concluded that crosslinked sodium hyaluronate was superior in reducing trans-epidermal water loss (27.8% reduction) compared to high molecular weight HA (15.6% reduction), while low molecular weight HA surprisingly increased TEWL. This supports the use of stabilized HA forms for effective skin hydration.
https://theordinary.com/en-us/multi-peptide-ha-serum-100613.html – This source provides product information and claims for The Ordinary Multi-Peptide + HA Serum. It highlights the serum's benefits in reducing wrinkles and improving skin texture, and lists its key ingredients and formulation characteristics, such as being vegan and free from common irritants.