Sphaeranthus Indicus Flower Head Extract
Also known as: Sphaeranthus indicus, East Indian Globe Thistle
Overview
Sphaeranthus indicus, also known as East Indian Globe Thistle, is a botanical supplement derived from a plant widely used in traditional Indian (Ayurvedic) medicine. The flower head extract is valued for its potential health benefits, including immune modulation, antioxidant, and anti-inflammatory effects. Recent research has focused on its ability to enhance muscle performance and endurance, particularly when combined with Mangifera indica bark extract. While the available evidence is promising, further systematic reviews are needed to fully understand its range of benefits and optimal usage. Sphaeranthus indicus is available primarily in capsule or powder form and is often marketed towards individuals seeking to improve their physical performance. Its purported mechanism of action involves enhancing nitric oxide production and improving mitochondrial function.
Benefits
Sphaeranthus indicus flower head extract, often used in conjunction with Mangifera indica bark, has demonstrated potential benefits in enhancing muscle strength and endurance in healthy men. Studies have shown statistically significant improvements in these areas following supplementation. Additionally, a reduction in cortisol levels has been observed, which may contribute to improved recovery and reduced muscle breakdown. While these benefits are primarily documented in young, healthy males engaged in resistance training, the antioxidant, anti-inflammatory, and immune-modulating effects of Sphaeranthus indicus suggest potential broader applications. However, more research is needed to confirm these secondary effects and to determine the optimal dosage and duration of supplementation for various populations.
How it works
Sphaeranthus indicus is believed to enhance muscle performance through several biological pathways. Primarily, it may boost nitric oxide production, which improves blood flow and nutrient delivery to muscles. Additionally, it could enhance mitochondrial function, increasing energy production within muscle cells. The extract may also activate the mTOR pathway, a key regulator of muscle protein synthesis and growth. These mechanisms collectively contribute to improved muscle strength, endurance, and recovery. The interaction with the muscular and cardiovascular systems is central to its effects, with endothelial nitric oxide synthase (eNOS) being a potential molecular target.
Side effects
While Sphaeranthus indicus is generally considered safe, comprehensive safety data are currently limited. Common, uncommon, and rare side effects are not well-documented, necessitating caution and further research. Potential drug interactions should be considered, particularly with medications affecting blood pressure or blood sugar levels, given the extract's antioxidant and anti-inflammatory properties. Due to limited safety data, pregnant or breastfeeding women should consult healthcare providers before use. Individuals with pre-existing medical conditions should also seek medical advice before starting supplementation. As with any supplement, it is important to monitor for any adverse reactions and discontinue use if they occur.
Dosage
Studies investigating the effects of Sphaeranthus indicus on muscle performance have typically used it in combination with Mangifera indica. Dosages in these studies have ranged from 425 mg to 850 mg per day of the combined extracts. However, the optimal dosage range for Sphaeranthus indicus alone is not well-established. It is often taken before or after exercise to maximize its potential benefits. Sphaeranthus indicus is commonly available in capsule or powder form. Due to the limited research, the maximum safe dose and any required cofactors are not well-documented. It is advisable to start with a lower dose and gradually increase it while monitoring for any adverse effects.
FAQs
How is Sphaeranthus indicus typically used?
It is often combined with other supplements like Mangifera indica for enhanced effects on muscle strength and endurance, typically taken before or after exercise.
Is Sphaeranthus indicus safe to use?
While generally considered safe, more research is needed on long-term safety and potential interactions, especially for pregnant or breastfeeding women.
When should I take Sphaeranthus indicus?
It is best taken in conjunction with a resistance training regimen to improve muscle strength and endurance over several weeks.
What results can I expect from taking Sphaeranthus indicus?
Users may experience improved muscle strength and endurance over several weeks when combined with exercise. It is not a substitute for proper exercise and nutrition.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9899043/ – This randomized controlled trial (RCT) with 99 men over 8 weeks found that a blend of Sphaeranthus indicus and Mangifera indica extract improved muscle strength and endurance. The study was limited to healthy young men, and the quality was assessed as moderate due to the specific population focus, but it provides evidence for the supplement's efficacy.
- https://foodandnutritionresearch.net/index.php/fnr/article/view/8972 – This RCT examined the effects of LI12542F6 supplementation and found that it increased muscle strength and size and improved endurance. Specific details on sample size and duration were not provided, leading to a moderate quality assessment due to the lack of detailed methodology, but it supports the potential benefits of the supplement.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11099261/ – This article examines the effects of LI12542F6 supplementation and found that it increased muscle strength and size and improved endurance. Specific details on sample size and duration were not provided, leading to a moderate quality assessment due to the lack of detailed methodology, but it supports the potential benefits of the supplement.
- https://www.ijpsonline.com/articles/a-metaanalysis-of-isphaeranthus-indicusi-and-igarcinia-mangostanai-products-on-cardiometabolic-outcomes-in-obese-patient.pdf – This meta-analysis of Sphaeranthus indicus and Garcinia mangostana products showed consistent effects on anthropological and lipid profiles. While not specifically focused on muscle performance, the high-quality systematic review methodology supports the broader health benefits of Sphaeranthus indicus.
- https://foodandnutritionresearch.net/index.php/fnr/article/download/8972/15277/ – This RCT examined the effects of LI12542F6 supplementation and found that it increased muscle strength and size and improved endurance. Specific details on sample size and duration were not provided, leading to a moderate quality assessment due to the lack of detailed methodology, but it supports the potential benefits of the supplement.