Spilanthes Extract
Also known as: *Acmella oleracea*, Toothache plant, Paracress, Jambu, *Spilanthes acmella*
Overview
*Spilanthes acmella* is a herbaceous plant native to the tropical regions of Central and South America. Known for its bioactive compounds, particularly spilanthol, this plant has been utilized in traditional medicine for its local anesthetic, anti-inflammatory, and aphrodisiac properties. The extract has garnered interest for its potential therapeutic applications, including relief from dental pain, enhancement of male sexual function, stimulation of muscle growth, and as an immunomodulatory agent. Despite the promising results from pre-clinical studies and some small human trials, further comprehensive research is necessary to confirm its efficacy and safety profile. Currently, the majority of evidence stems from in vitro and animal studies, with limited high-quality human clinical trials available.
Benefits
Research indicates several potential benefits of *Spilanthes acmella* extract: 1. **Erectile Function**: Studies have shown that the extract enhances erectile function in both animal models and humans, with improvements noted in erectile response times and frequency of sexual activity. A systematic review reported significant outcomes in male patients with erectile dysfunction (ED)[1]. 2. **Muscle Mass**: Data from a longitudinal study highlighted the extract's role in increasing muscle mass among male participants, with measurements showing notable gains in muscular circumference after consistent use over 2 months[5]. 3. **Immunomodulation**: Ethanol extracts displayed an ability to stimulate macrophage activity, suggesting potential uses for enhancing immune responses[2]. 4. **Anti-inflammatory Effects**: Known for its local anesthetic properties, the extract also inhibits inflammatory mediators, contributing to its overall therapeutic profile. Therefore, while evidence supports these benefits primarily in male sexual health and muscle growth, ongoing research is needed to substantiate these claims and explore additional applications.
How it works
The bioactive compound spilanthol in *Spilanthes acmella* acts on various biological pathways, particularly by inhibiting nitric oxide production and modulating NF-κB activation, which plays an essential role in inflammatory responses and immune functions. The extract promotes smooth muscle relaxation, which directly impacts erectile function enhancement. Furthermore, through stimulating macrophages, it appears to enhance the immune response, positioning the extract as a potential natural immunostimulant.
Side effects
Overall, *Spilanthes acmella* extract is regarded as safe when used as directed; however, detailed safety studies are limited. Common side effects are not well documented, though localized use has generally been well-tolerated. There have been no reported drug interactions or severe adverse effects; nevertheless, caution is advised, particularly for pregnant or breastfeeding women due to insufficient safety data in these populations. Given the extract's effects on smooth muscle, individuals with certain health conditions or those taking medications that impact blood flow should consult healthcare providers before use. Long-term effects remain uncertain, and additional research is warranted to create a complete safety profile.
Dosage
The effective dosage of *Spilanthes acmella* extract has not been firmly established, but studies commonly utilize doses ranging from 500 mg to 3 g per day of extract standardized to contain 3.5% spilanthol, translating to approximately 17.5 mg of spilanthol daily[5]. Due to its diverse applications, the timing of ingestion is flexible, though it should be taken consistently as part of a daily regimen. Forms of the supplement may vary, including capsules and extracts, which can affect absorption rates. While an upper limit for safe consumption is not clearly defined, it is prudent to start with lower doses and monitor for any adverse effects.
FAQs
Is *Spilanthes acmella* safe for long-term use?
While generally considered safe, comprehensive long-term data is lacking. Use caution, especially in special populations.
How should I take *Spilanthes acmella*?
It can be taken in various formats, typically consumed daily without specific timing recommendations.
When can I expect results from using this extract?
Improvements in erectile function and muscle mass are often seen within several weeks to a couple of months.
Can I use *Spilanthes acmella* as a replacement for prescribed medication?
No, it should not substitute for medical treatments; always consult a healthcare professional for guidance.
Research Sources
- https://www.phcogrev.com/sites/default/files/PharmacognRev-15-29-1.pdf – This systematic review synthesizes available research on *Spilanthes acmella*, highlighting its pharmacological effects, particularly in erectile dysfunction, with significant findings supporting its efficacy over placebo.
- https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/5752361bda6d1d2d727801c1cf42e933.pdf – This paper explores the muscle-enhancing properties of *Spilanthes acmella*, documenting increases in muscle mass across a long-term study of male participants receiving the extract.
- https://f1000research.com/articles/13-790 – Preclinical studies in this article reveal the immunomodulatory and local anesthetic effects of *Spilanthes acmella*, substantiating its traditional use in medicine through evidence-based results.
- https://www.mdpi.com/2223-7747/10/2/198 – This review discusses the broader pharmacological applications of *Spilanthes acmella*, focusing on its effects on inflammation and immune response, and emphasizes the need for more extensive human studies.
- https://pubmed.ncbi.nlm.nih.gov/35136796/ – A recent clinical trial exploring the effects of *Spilanthes acmella* on erectile dysfunction showed notable improvements, underscoring the need for larger-scale studies for definitive conclusions.
