Standardized Deglycyrrhized Licorice Extract
Also known as: DGL, Deglycyrrhizinated Licorice, Glycyrrhiza glabra extract, Standardized Deglycyrrhized Licorice Extract
Overview
Standardized Deglycyrrhized Licorice Extract (DGL) is derived from the root of the *Glycyrrhiza glabra* plant, traditionally used to address gastrointestinal disorders and flavoring foods. Unlike standard licorice extracts, DGL undergoes processing to remove glycyrrhizin, a compound associated with adverse effects like hypertension and hypokalemia. DGL's primary purpose is to support gastrointestinal health, alleviating symptoms from digestive issues such as peptic ulcers and *Helicobacter pylori* infections. Recent studies are investigating its impact on liver health and weight management. DGL is available in various forms, including wafers, capsules, and liquid extracts, ensuring usability and enhanced absorption compared to regular licorice. Research indicates significant potential benefits, although continued studies are necessary to fully understand its capabilities.
Benefits
DGL offers research-supported health benefits, prominently improving *H. pylori* eradication rates when used alongside standard treatment protocols, as evidenced by clinical trials with around 120 participants. Systematic reviews confirm its efficacy in alleviating gastric and intestinal discomfort, with meta-analyses demonstrating reductions in dyspepsia and hyperlipidemia. A comprehensive meta-analysis of 26 clinical trials revealed modest but significant effects on body weight and BMI, highlighting the necessity of consistent usage for tangible results. The extract’s soothing properties are particularly beneficial for individuals with gastrointestinal conditions, complementing lifestyle modifications and dietary adjustments.
How it works
DGL operates primarily through its interaction with the gastrointestinal system. By eliminating glycyrrhizin, it retains beneficial flavonoids and isoflavonoids that provide anti-inflammatory effects and enhance protective roles in the gastrointestinal mucosa. These components bolster mucosal integrity and mitigate inflammation, promoting stomach and intestinal health. Consequently, DGL helps reduce irritation symptoms and supports the healing of gastrointestinal tissues.
Side effects
DGL is generally well tolerated, with a favorable safety profile compared to standard licorice due to the removal of glycyrrhizin. Common side effects occur infrequently (>5%), primarily mild gastrointestinal discomfort, while rare allergic reactions are also noted. Less common side effects are not explicitly listed but are classified as occurring at rates between >1% and <5%. Very rare side effects (<1%) suggest minimal adverse reactions overall. Caution is advised when using DGL concomitantly with potassium-affecting medications or blood pressure drugs. Individuals with a history of high blood pressure or low potassium should take extra care. Pregnant and breastfeeding women are advised to avoid DGL due to possible estrogenic effects, and those with health concerns should seek medical advice.
Dosage
Dosage for DGL typically ranges from 760 mg to 4.5 grams daily, ideally segmented into doses before meals to maximize efficacy. A minimum dose of 760 mg is usually sufficient to achieve therapeutic effects, while for prolonged use, doses should not exceed 4.5 grams per day for more than four months. Timing is crucial—taking DGL about 20 minutes before meals is recommended for optimal gastrointestinal health outcomes. The extract is available in various forms such as wafers, capsules, and liquid extracts, with wafers often preferred for their chewable nature and better absorption characteristics, enhancing bioavailability compared to standard licorice.
FAQs
Is DGL safe for everyone?
While DGL is considered safer than regular licorice extracts, it should be used under medical supervision, especially in pregnant or lactating women and those with certain health conditions.
When should I take DGL?
DGL is recommended to be taken 20 minutes before meals to maximize its benefits on gastrointestinal health.
What results can I expect from using DGL?
Users can anticipate improvements in gastrointestinal symptoms within a few weeks of consistent DGL use, including reduced inflammation and discomfort.
Are all licorice products safe to use?
Not all licorice products are safe; only deglycyrrhizinated licorice extracts avoid the adverse effects linked to glycyrrhizin.