Standardized Hops
Also known as: Humulus lupulus, Hops, Hop Extract
Overview
Humulus lupulus, commonly known as hops, is a plant primarily recognized for its use in brewing beer. However, it also contains phytoestrogenic compounds, notably 8-prenylnaringenin (8-PN), which have garnered attention for potential health benefits. Hops are derived from the flowers of the hop plant and are available in various forms, including standardized extracts and capsules. These extracts are often used to alleviate menopausal symptoms, support bone health, and potentially improve joint health. The phytoestrogenic properties of hops, particularly 8-PN's action as an estrogen receptor agonist, are central to its purported benefits. Research on hops is ongoing, with clinical trials exploring its efficacy in different health applications. While the quality of evidence varies, several studies suggest promising outcomes, particularly for postmenopausal women.
Benefits
Standardized hop extracts, particularly those containing 8-prenylnaringenin (8-PN), have shown potential benefits for menopausal symptoms and bone health. Studies indicate that combined soy and hop extracts can significantly reduce menopausal symptoms like hot flashes and night sweats. For example, one study reported a notable decrease in the Kupperman Menopausal Index (KMI) scores. Additionally, hop extracts may improve bone health in postmenopausal women with osteopenia, as suggested by randomized controlled trials. While evidence is less robust, some studies suggest potential benefits for joint health. These benefits are typically observed within weeks to months of consistent supplementation, making hops a promising option for managing specific health concerns in certain populations.
How it works
Hops exert their effects primarily through their phytoestrogenic activity, particularly via the compound 8-prenylnaringenin (8-PN). This compound acts as an estrogen receptor agonist, modulating the endocrine system and influencing hormone balance. By targeting estrogen receptors, 8-PN can mimic estrogenic effects, potentially impacting bone density and alleviating menopausal symptoms. The precise mechanisms of absorption and bioavailability are not fully understood, but oral administration is a common method. This interaction with the endocrine system and estrogen receptors underlies the potential benefits observed in bone health and menopausal symptom management.
Side effects
Hops are generally considered safe, with few reported side effects in clinical trials. The most commonly reported side effects are mild gastrointestinal issues. Uncommon side effects may include potential hormonal interactions, although these are not frequently reported. Due to its hormonal effects, hops are contraindicated during pregnancy and breastfeeding. Caution is advised for individuals with hormone-sensitive conditions, as hops may interact with hormone-sensitive medications. While rare side effects are not well-documented, it is essential to monitor for any adverse reactions and consult with a healthcare provider, especially when taking other medications or managing pre-existing health conditions. Overall, the safety profile of hops is favorable, but awareness of potential interactions and contraindications is crucial.
Dosage
Optimal dosage ranges for standardized hop extracts typically involve doses containing around 100 µg of 8-PN per day, as used in several studies. Consistent daily dosing is recommended to achieve the desired effects. While a minimum effective dose is not definitively established, this range has shown promise in clinical trials. The maximum safe dose is also not well-defined, but higher doses may increase the risk of hormonal interactions. Capsules are a common form for supplementation. Due to limited data on absorption factors, it is advisable to follow the recommendations of healthcare providers or product labels. No specific cofactors are required for hop extract supplementation.
FAQs
Are there any interactions with medications?
Hops may interact with hormone-sensitive medications. Consult with a healthcare provider before use, especially if you are taking other medications or have hormone-sensitive conditions.
Who should avoid taking hops?
Pregnant and breastfeeding women should avoid hops due to its hormonal effects. Individuals with hormone-sensitive conditions should also exercise caution.
What are the expected benefits of taking hops?
Hops may help improve menopausal symptoms and potentially benefit bone health. Consistent daily dosing is recommended for optimal results.
Is hops just for brewing beer?
No, hops have potential health benefits due to their phytoestrogenic properties. Standardized extracts are used for menopausal symptom relief and bone health support.
How should I take hops?
Consistent daily dosing is recommended. Follow the recommendations of healthcare providers or product labels for optimal results.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10304064/ – This randomized controlled trial examined the effect of hop extract standardized in 8-PN on bone health in postmenopausal women with osteopenia. The study found potential benefits for bone health, suggesting that hop extract may be a useful supplement for improving bone density in this population.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4853989/ – This systematic review and meta-analysis on the use of hops for menopausal vasomotor symptoms highlighted the potential benefits but noted the need for more robust evidence. The review suggests that hops may help alleviate menopausal symptoms, but further research is needed to confirm these findings.
- https://austinpublishinggroup.com/nutrition-metabolism/fulltext/ajnm-v9-id1124.pdf – This study focuses on the combined efficacy of soy and hop extracts for menopausal symptoms. The research indicates significant improvements in menopausal symptoms compared to placebo, suggesting a synergistic effect between soy and hop extracts in alleviating these symptoms.
- https://www.liebertpub.com/doi/abs/10.1089/acm.2021.0027 – This study investigates the impact of hop extract on menopausal discomforts. The findings suggest that hop extract may reduce various menopausal symptoms, contributing to an improved quality of life for menopausal women.
- https://pubs.acs.org/doi/10.1021/acs.chemrestox.8b00345 – This research explores the chemical and toxicological aspects of hop compounds. It provides insights into the safety profile and potential risks associated with hop extracts, contributing to a better understanding of their overall health effects.
Supplements Containing Standardized Hops
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