Stephania Tetrandra Root Extract
Also known as: Fangji, Stephania tetrandra root, *Stephania tetrandra*
Overview
*Stephania tetrandra* is a perennial herb used in traditional Chinese medicine, primarily for its roots, which are known for their bioactive compounds, including tetrandrine and fangchinoline. This plant is traditionally utilized to treat various ailments, including rheumatism, rheumatoid arthritis, edema, and hypertension. The root extract contains high levels of benzylisoquinoline alkaloids (BIAs), which contribute to its pharmacological effects. Research on *S. tetrandra* is moderate, indicating increasing interest in its health benefits but highlighting the variability and quality of available evidence. Human clinical trials remain sparse, necessitating further investigation into its efficacy and safety as an herbal supplement.
Benefits
Research indicates several potential benefits of *S. tetrandra*, notably cardiovascular enhancements, such as improvements in ischemic heart diseases and hypertension observed primarily through animal studies. Additionally, its anti-inflammatory and anticancer properties have been reported. For instance, fangchinoline has shown promise in inducing apoptosis in T cells, suggesting possible therapies for autoimmune diseases like Sjogren's syndrome. While individuals suffering from rheumatic diseases or hypertension may particularly benefit, limited human data prevent precise quantification of these effects, indicating that more rigorous research is urgently needed to validate these findings.
How it works
The primary mechanism of action for *Stephania tetrandra*, particularly attributed to tetrandrine, involves its role as a calcium channel blocker, which can provide cardiovascular protection. Additionally, fangchinoline interacts with the immune system by inducing apoptosis in T cells through oxidative stress pathways, potentially benefiting autoimmune conditions. These effects indicate that the extract influences both cardiovascular and immune system responses, although further research is needed to clarify the extent of this interaction.
Side effects
Generally, *Stephania tetrandra* is considered safe when used in traditional contexts, but modern clinical safety data are still insufficient. Common side effects are not well-documented; however, gastrointestinal disturbances and allergic reactions have been noted infrequently. No severe adverse effects are reported, but caution is advised, particularly for patients with pre-existing cardiovascular conditions or those taking medications that influence blood pressure. Furthermore, there are potential drug interactions, especially with calcium channel blockers and immunosuppressants. Lack of safety data makes its use during pregnancy and breastfeeding a concern, emphasizing the need for careful consultation with health professionals before its use.
Dosage
There is no established minimum effective dose or standardized dosing regimen for *Stephania tetrandra*, as traditional applications vary significantly. Optimal dosages remain undetermined, with no specific upper limits identified. As a root extract, it is typically consumed without exact timing considerations. Given the lack of absorption data, practitioners should exercise caution, particularly for individuals with health conditions or those on medication, by seeking professional guidance regarding its use.
FAQs
What should I consider before using Stephania tetrandra?
Consult a healthcare provider prior to use, especially if you're taking medications or have underlying health issues.
Is it safe to use during pregnancy or breastfeeding?
Due to limited safety data, *S. tetrandra* is not recommended during pregnancy or breastfeeding.
How should I take this supplement?
There are no specific guidelines for timing or administration; traditional use varies widely.
What results can I expect from using this extract?
Expect varied results; significant research is needed to establish definitive outcomes.
Can I rely on this herb instead of prescribed medication?
No, *Stephania tetrandra* should not substitute for prescribed treatments without evidence of efficacy.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/11603280/ – This study compared the cardiovascular effects of *S. tetrandra* extract with tetrandrine, finding similar benefits in reducing infarct size and arrhythmias without significantly affecting heart rate.
- https://pubmed.ncbi.nlm.nih.gov/36809961/ – Fangchinoline was discovered to induce apoptosis in Jurkat T cells, indicating potential advantages for the treatment of autoimmune diseases.
- https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2022.874583/full – This transcriptome analysis provided insights into the biosynthesis of benzylisoquinoline alkaloids in *S. tetrandra*, revealing the complexity of its pharmacological profile.
- https://www.paulaschoice.co.uk/stephania-tetrandra-root-extract/ingredient-stephania-tetrandra-root-extract.html – An overview of *Stephania tetrandra*'s traditional uses and components, highlighting its application in herbal medicine.
- https://www.mdpi.com/1424-8247/17/10/1356 – Focuses on the pharmacological properties of various alkaloids found in *S. tetrandra*, enhancing the understanding of its therapeutic potential.
