ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Collinsonia Root Plant Extract

Also known as: Collinsonia root, stone root, knob root, Collinsonia canadensis

Overview

Collinsonia root is derived from *Collinsonia canadensis*, a perennial herb native to eastern North America, belonging to the mint family. The root is dark brown, knotty, and has a long history of traditional use in herbal medicine, primarily for digestive health, venous support, and as a mild sedative. It contains bioactive compounds such as rosmarinic acid, tannins, flavonoids, and saponins, which are believed to contribute to its purported antioxidant, anti-inflammatory, and vascular-supportive properties. While traditionally used for conditions like hemorrhoids, digestive disorders, and circulatory issues, scientific research on Collinsonia root is limited, with most evidence being preclinical or anecdotal rather than from robust clinical trials.

Benefits

Collinsonia root is traditionally used for several benefits, though robust clinical evidence is largely lacking. It is believed to support **digestive health** by stimulating digestion, improving appetite, reducing gastrointestinal spasms, and promoting peristalsis, potentially alleviating indigestion, colic, and chronic gastritis. Its historical use also points to **venous and vascular support**, particularly for conditions like hemorrhoids and varicose veins, by promoting vein integrity and supporting blood vessel tone. The presence of rosmarinic acid and flavonoids suggests potential **antioxidant and anti-inflammatory effects**, which could help reduce oxidative stress and inflammation, although clinical validation is sparse. Additionally, mild **sedative and muscle relaxant** effects have been anecdotally reported, possibly aiding in muscle relaxation and pain relief.

How it works

The purported mechanisms of action for Collinsonia root are attributed to its bioactive compounds, including rosmarinic acid, tannins, flavonoids, and saponins. These compounds are thought to mediate antioxidant and anti-inflammatory effects within the body. In the gastrointestinal tract, it may act on smooth muscle to reduce spasms and promote peristalsis, thereby aiding digestion and bowel motility. The vascular benefits, particularly for venous tone and capillary function, are likely due to flavonoids, though the precise molecular targets and pathways are not well characterized. Information regarding the absorption and bioavailability of these compounds in human studies is currently not well documented.

Side effects

Collinsonia root is generally regarded as safe when used in traditional doses, but comprehensive safety data from clinical trials are lacking. There are no well-documented common side effects, and traditional use has not reported significant adverse effects. Due to the limited clinical data, no major drug interactions or contraindications have been definitively established. However, caution is advised for individuals who are pregnant, lactating, or have chronic medical conditions, as there is insufficient safety evidence for these populations. Users should be aware that the absence of reported side effects does not equate to proven safety, especially with long-term use or in sensitive individuals.

Dosage

There is no standardized dosing established for Collinsonia root from clinical trials, as most usage is based on historical and traditional practices. Traditional preparations include teas, tinctures, and various extracts, with dosages derived from historical use rather than evidence-based guidelines. Due to this lack of standardization, it is recommended to start with small amounts to assess individual tolerance. The concentration of active compounds can vary significantly depending on the extraction method and product formulation, which further complicates consistent dosing. Upper limits and safety thresholds have not been determined through rigorous scientific study.

FAQs

Is Collinsonia root effective for hemorrhoids?

Traditional use supports its application for hemorrhoids, suggesting benefits for venous health. However, high-quality clinical trials are lacking to definitively confirm its efficacy.

Can Collinsonia root be used for kidney stones?

Historically, it has been used to facilitate the removal of calculi. Nevertheless, there is no rigorous scientific evidence to confirm its efficacy for kidney stones.

Is Collinsonia root safe for long-term use?

Safety data for long-term use are insufficient. Due to the lack of comprehensive studies, long-term use should be approached with caution and under professional guidance.

How quickly do effects appear when using Collinsonia root?

Anecdotal reports suggest that effects on digestion may be noticed within a few days. However, there are no clinical data to provide a definitive timeline for the onset of effects.

Research Sources

  • https://www.healthline.com/nutrition/collinsonia-root – This article provides an overview of Collinsonia root, detailing its traditional uses, potential benefits, and the lack of scientific evidence to support many of its claims. It highlights the need for more research.
  • https://wholisticmatters.com/collinsonia-root-digestive-health/ – This source from WholisticMatters discusses the traditional uses of Collinsonia root for digestive health, drawing on historical and phytochemical data. It acknowledges the absence of controlled clinical evidence.
  • https://wholisticmatters.com/collinsonia-root-a-remedy-rooted-in-american-history/ – This article delves into the historical context of Collinsonia root as an American herbal remedy, outlining its traditional applications and the cultural significance of its use over time.
  • https://www.henriettes-herb.com/eclectic/kings/collinsonia.html – This historical text provides insights into the eclectic medical uses of Collinsonia root, detailing its applications and preparations as understood by herbalists in the past, reflecting traditional knowledge.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC3956726/ – This PubMed Central article, while not directly on Collinsonia, may provide context on herbal medicine research or related compounds. (Note: Specific content not provided, summary is general based on PMC link).
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC5871264/ – This PubMed Central article, similar to the previous, likely offers insights into botanical research or traditional medicine. (Note: Specific content not provided, summary is general based on PMC link).