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Streptococcus Salivarius Blis M18

Also known as: S. salivarius M18, BLIS M18, Lactic acid bacteria, Streptococcus salivarius BLIS M18

Overview

Streptococcus salivarius BLIS M18 is a specific strain of the probiotic bacterium S. salivarius, recognized for its potential health benefits, especially in oral health. This strain is notable for its ability to produce bacteriocins and lantibiotics that target harmful bacteria such as Streptococcus mutans, a significant contributor to dental caries. Research has shown that S. salivarius M18 aids in the reduction of dental plaque and offers antimicrobial protection against oral pathogens. It is typically available as a dietary supplement and can be enhanced in efficacy when combined with specific prebiotics. Despite promising results, comprehensive systematic reviews on its efficacy are limited, highlighting the need for further evidence to substantiate its health claims.

Benefits

Streptococcus salivarius BLIS M18 has demonstrated several benefits, particularly in oral health. Evidence indicates that it can significantly reduce plaque scores and inhibit the growth of Streptococcus mutans, thus preventing dental caries (randomized controlled trials with 100 children). Additionally, there are indications of systemic benefits such as increased plasma nitrite levels, suggesting possible cardiovascular advantages; however, confirmation through further research is required. Strength of evidence varies, with high-quality trials supporting oral health effects, while systemic effects remain less established. Overall, children with high initial plaque levels particularly benefit from S. salivarius M18 supplementation.

How it works

The antimicrobial effect of Streptococcus salivarius BLIS M18 is primarily mediated through its production of bacteriocins and lantibiotics that specifically target cariogenic bacteria like S. mutans. The effective colonization of the oral cavity by this strain limits the establishment and biofilm formation of harmful bacteria, contributing to an improved oral microbiome. Additionally, the presence of synbiotic sugars such as raffinose enhances the production of its antimicrobial compounds, increasing its protective effects against pathogens in the mouth.

Side effects

Streptococcus salivarius BLIS M18 is generally regarded as safe, with minimal reported side effects. However, individuals with compromised immune systems or underlying health issues may experience gastrointestinal disturbances or allergic reactions. No severe adverse effects have been consistently observed in clinical studies. As a precaution, users should consult healthcare providers before starting supplementation, especially if they are on immunosuppressive therapy or have a history of severe allergies. Drug interactions have not been extensively studied, but monitoring is advisable when used alongside antibiotics or antifungal medications.

Dosage

The recommended dosage for Streptococcus salivarius BLIS M18 typically ranges from 1 to 10 billion CFUs (colony-forming units) per day, depending on the specific formulation and intended health outcomes. Timing can vary, but it is usually suggested to take the supplement in the morning or before meals for optimal absorption. Higher doses may be beneficial for children with significant oral health issues, while maintenance doses can be lower. Safety thresholds for this probiotic strain have not been firmly established, thus sticking to the manufacturer's guidelines and consultation with a healthcare provider is recommended for best practices.

FAQs

What are the main health benefits of S. salivarius M18?

S. salivarius M18 mainly offers benefits in preventing dental caries by reducing plaque and inhibiting harmful oral bacteria. Limited evidence suggests potential cardiovascular benefits through increased plasma nitrite levels.

How should I take S. salivarius M18 for the best results?

For optimal results, take S. salivarius M18 in the morning or before meals, adhering to recommended dosages ranging from 1 to 10 billion CFUs daily.

Are there any side effects associated with this probiotic strain?

S. salivarius M18 is generally safe, with few reported side effects. However, consult a healthcare provider if you have an immune condition or experience adverse reactions.

Can S. salivarius M18 be used alongside antibiotics?

While interactions are not well-studied, it’s advisable to monitor its use with antibiotics and consult a healthcare professional to ensure safety and efficacy.

Is there enough research supporting the use of S. salivarius M18?

There is promising evidence for its oral health benefits, but more comprehensive studies, including systematic reviews, are needed to fully establish its efficacy.

Research Sources

https://www.mdpi.com/2673-8007/3/3/54 – This study investigates the effects of S. salivarius M18 on dental plaque and caries in children, showing significant reductions in plaque formation and promising implications for dental health.
https://www.mdpi.com/2673-8007/4/3/91 – The article discusses the antimicrobial properties of S. salivarius M18, revealing its inhibition of S. mutans biofilm formation, which is crucial for maintaining oral hygiene.
https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.056663-0 – This research highlights the bacteriocin production in S. salivarius M18 and its effectiveness against cariogenic bacteria, alongside potential systemic health benefits.
https://pubmed.ncbi.nlm.nih.gov/23449874/ – A study revealing the effects of S. salivarius M18 on plasma nitrite levels and discussing its potential for cardiovascular benefits, though further research is needed for conclusive evidence.
https://www.tandfonline.com/doi/full/10.1080/20002297.2024.2304971 – This article reviews the overall effectiveness of probiotics, including S. salivarius M18, in oral health, emphasizing the need for systematic review to substantiate claims.