Sunactive Iron
Also known as: SunActive Fe, micronized ferric pyrophosphate, dispersible ferric pyrophosphate, Ferric pyrophosphate
Overview
SunActive Fe is a micronized, dispersible form of ferric pyrophosphate, engineered to enhance bioavailability and stability. Unlike its natural counterparts, this form is synthesized specifically for iron supplementation, making it particularly useful for individuals with iron deficiency or anemia. Its small particle size and water-soluble nature allow for better absorption and fewer gastrointestinal side effects. Research on SunActive Fe is mature, covering various studies including in vitro, animal, and human trials, demonstrating its efficacy for improving iron status and increasing hemoglobin levels. It is often used in food fortification as well as dietary supplements, providing a practical solution for addressing iron deficiencies.
Benefits
SunActive Fe presents several evidence-based benefits, including superior bioavailability. Research indicates an almost four-fold increase in absorption via M cells compared to other iron sources. Clinical studies report significant increases in hemoglobin levels, with informed studies showing consistent improvements as early as six weeks post-supplementation. Additionally, SunActive Fe has a favorable side effect profile, exhibiting gastrointestinal side effects in less than 12% of users. Notably, it is particularly effective for iron-deficient individuals and may offer benefits for pregnant women by improving iron status with fewer adverse effects.
How it works
SunActive Fe utilizes a unique absorption mechanism involving endocytosis, which allows its micronized particles to bypass the traditional iron absorption pathway. This mechanism ensures efficient uptake in the gastrointestinal tract with minimal irritation. Once absorbed, the iron is integrated into the body’s iron stores, specifically in ferritin located in enterocytes, the liver, and bone marrow, enhancing overall iron availability in the body.
Side effects
SunActive Fe is well-tolerated overall, but some gastrointestinal side effects, such as nausea and constipation, may still occur, albeit at lower rates compared to traditional iron supplements. These effects are typically mild and infrequent, affecting less than 12% of users. While uncommon side effects are not well-documented, the encapsulated formulation suggests minimal risk. There are no significant rare side effects reported. Interactions with other minerals or medications might occur, necessitating caution. Contraindications include conditions like hemochromatosis, where iron overload is a concern. Special populations such as pregnant women or those with chronic conditions should consult a healthcare provider prior to initiation.
Dosage
The ideal dosage of SunActive Fe typically ranges from 30 mg to 60 mg of elemental iron daily. Recent studies suggest a minimum effective dose of approximately 30 mg, while higher doses are often utilized depending on an individual's iron needs. The maximum safe dose does not typically exceed 120 mg of elemental iron per day. For optimal absorption, it is recommended to take SunActive Fe on an empty stomach; however, if side effects occur, it can be taken with food. This supplement can be incorporated into a variety of food products and beverages, leveraging its stability and low reactivity to enhance dietary iron intake.
FAQs
Is SunActive Fe safe?
Yes, SunActive Fe is generally safe, with a lower incidence of gastrointestinal side effects compared to other iron supplements.
When is the best time to take SunActive Fe?
It can be taken anytime, but it's ideally consumed on an empty stomach for better absorption.
How quickly can I expect results from SunActive Fe?
Improvements in hemoglobin and ferritin levels are typically observable within 6 weeks of supplementation.
What is the difference between SunActive Fe and ferrous supplements?
SunActive Fe is a ferric pyrophosphate, offering different absorption characteristics compared to ferrous iron supplements.
Research Sources
- https://www.mdpi.com/1424-8247/11/4/97 – This study highlights the bioavailability and efficacy of SunActive Fe compared to other oral iron formulations, demonstrating significant increases in hemoglobin and iron status in patients with iron deficiency anemia.
- https://pubmed.ncbi.nlm.nih.gov/19142566/ – A research article discussing the relative bioavailability of SunActive Fe showing it as a good source of iron with a slight underperformance compared to ferrous sulphate, indicating a solid profile for supplementation.
- https://www.taiyointernational.com/sunactive-fe/researchers-link-sunactive-fes-superior-bioavailability-to-its-unique-absorption-pathway/ – In vitro studies confirm SunActive Fe's absorption via endocytosis, contributing to its enhanced bioavailability among other iron pyrophosphate sources, although it emphasizes the need for human physiological validation.
- https://www.jbtr.or.kr/archive/view_article?pid=jbtr-23-4-131 – This clinical trial affirmed the safety and effectiveness of SunActive Fe in raising hemoglobin levels, with minimal gastrointestinal effects reported over a 24-week period.
- https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD004736.pub5/information – A Cochrane review assessing various iron supplementation strategies finds evidence supporting the effectiveness of different forms of iron, among which SunActive Fe is noted for its tolerability and absorption efficiency.