Superpure Chaste Tree Berry Extract
Also known as: Vitex agnus-castus, Chaste Tree, Chasteberry
Overview
Vitex agnus-castus, commonly known as Chaste Tree, is a plant native to the Mediterranean region and parts of Asia. The fruit of the plant is used to create extracts used as herbal supplements. It is primarily used to alleviate symptoms of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). The fruit extract is often standardized to contain specific compounds believed to influence hormonal balance. Research on Chaste Tree extract is considered moderate, with several clinical trials and meta-analyses assessing its efficacy for PMS symptoms. However, the quality of evidence varies; some studies are well-designed, while others lack detailed reporting or have methodological limitations. It is available in various forms, including capsules, tablets, and liquid extracts.
Benefits
Chaste Tree extract has demonstrated effectiveness in reducing PMS symptoms. Studies indicate that women taking Chaste Tree are significantly more likely to experience symptom remission compared to those on a placebo. Some research suggests its benefits are comparable to fluoxetine for certain symptoms, although results are mixed. It is primarily beneficial for women experiencing PMS or PMDD, with significant reductions in PMS symptoms reported. Benefits are typically observed within a few menstrual cycles. A meta-analysis showed women taking Chaste Tree were 2.57 times more likely to experience symptom remission compared to those on a placebo (95% CI 1.52-4.35).
How it works
Chaste Tree is believed to influence dopamine and serotonin pathways, potentially affecting hormonal balance and mood regulation. It may interact with the endocrine system to modulate hormonal levels. While the exact molecular targets are not fully elucidated, it may involve neurotransmitter receptors and hormonal pathways. Specific data on absorption and bioavailability is limited, but it is thought to affect the hypothalamic-pituitary-ovarian axis, which plays a key role in regulating the menstrual cycle.
Side effects
Chaste Tree is generally considered safe when used appropriately. Common side effects (occurring in >5% of users) include gastrointestinal issues, headache, and dizziness. Uncommon side effects (1-5%) include allergic reactions and acne. Rare side effects (<1%) include severe allergic reactions. There are potential interactions with dopamine antagonists and hormonal therapies. It is contraindicated during pregnancy and breastfeeding due to potential hormonal effects. Caution is advised in individuals with hormone-sensitive conditions. It's important to discontinue use and consult a healthcare professional if any adverse reactions occur.
Dosage
The typical minimum effective dose is around 20-40 mg of standardized extract per day. The optimal dosage range is generally 20-40 mg daily, although specific dosing may vary by product. It is generally not recommended to exceed 40 mg daily. Chaste Tree is often taken once daily, ideally at the same time each day. Standardized extracts are preferred over ground berries. Bioavailability may be influenced by the presence of other nutrients or medications. There are no specifically identified required cofactors.
FAQs
Is Chaste Tree safe during pregnancy or breastfeeding?
No, Chaste Tree is not recommended during pregnancy or breastfeeding due to its potential hormonal effects.
Can Chaste Tree interact with other medications?
Yes, Chaste Tree may interact with dopamine antagonists and hormonal therapies. Consult with a healthcare provider before use.
What are the common side effects of Chaste Tree?
Common side effects include gastrointestinal issues, headache, and dizziness. Discontinue use if you experience severe side effects.
When is the best time to take Chaste Tree?
It is best taken consistently once daily, ideally at the same time each day, to maintain stable levels in the body.
How long does it take to see results from Chaste Tree?
Improvement in PMS symptoms may be noticeable within a few menstrual cycles with consistent use.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/31780016/ – This meta-analysis of three studies with 520 females found that Chaste Tree extract significantly reduces PMS symptoms compared to placebo. The study highlights the potential of Chaste Tree as an effective treatment for PMS, though it notes limitations due to incomplete reporting in some included studies. The researchers concluded that Chaste Tree can be a beneficial alternative for women seeking relief from PMS.
- https://pubmed.ncbi.nlm.nih.gov/28237870/ – This systematic review and meta-analysis included seventeen RCTs and found that Chaste Tree was superior to placebo in nine out of ten studies and comparable to fluoxetine in some aspects. The review supports the efficacy of Chaste Tree for PMS symptoms, but acknowledges variability in dosages and preparations across studies. The authors suggest that Chaste Tree is a viable option for managing PMS, with evidence indicating its effectiveness.
- https://www.sciencedirect.com/topics/immunology-and-microbiology/vitex – This resource provides general information about Vitex agnus-castus, including its traditional uses and chemical constituents. It serves as a background reference for understanding the plant's properties and applications. While not a clinical study, it offers valuable context for the plant's historical and contemporary use.
- https://www.mdpi.com/1999-4907/11/7/761 – This phytochemical analysis identifies antiangiogenic compounds in Vitex agnus-castus. While the study does not directly relate to human health benefits, it provides insight into potential bioactive compounds within the plant. The research contributes to a better understanding of the plant's chemical composition and potential mechanisms of action.
- https://drtorihudson.com/botanicals/chaste-tree-effective-for-pms-in-meta-analysis/ – This article summarizes the findings of a meta-analysis, highlighting the effectiveness of Chaste Tree for PMS. It emphasizes the clinical significance of Chaste Tree in reducing PMS symptoms. The author suggests that Chaste Tree is a valuable option for women seeking natural remedies for PMS.