Superpure Ginger Rhizome Co2 Extract
Also known as: Zingiber officinale Roscoe CO₂ Extract, Superpure Ginger Rhizome CO₂ Extract, Ginger CO₂ Extract, Ginger Rhizome CO₂ Extract, Ginger Root CO₂ Extract, Zingiber officinale CO₂ Extract
Overview
Superpure Ginger Rhizome CO₂ Extract is a concentrated form of ginger (*Zingiber officinale*) obtained through supercritical CO₂ extraction. This method preserves key bioactive compounds like gingerols and shogaols. It is primarily used for digestive support, anti-inflammatory effects, and as an antioxidant. Traditional uses include relief from nausea, motion sickness, and joint discomfort. The extract is typically standardized for potency and free from synthetic additives. Ginger is well-studied, but research specific to CO₂ extracts is less extensive than that of traditional extracts. Evidence supports ginger's anti-inflammatory and digestive benefits, while CO₂ extract-specific benefits are emerging. It is available in capsule form, with dosages standardized based on gingerol and shogaol content. The extract offers a potent alternative to traditional ginger supplements.
Benefits
Ginger CO₂ extract provides anti-inflammatory and digestive support. Studies show ginger significantly lowers CRP, hs-CRP, and TNF-α levels, with CRP reductions ranging from 0.5 to 1.5 mg/L. It is effective for reducing nausea and vomiting, with statistically significant improvements in symptoms compared to placebo (p < 0.05). Ginger is particularly beneficial for nausea during pregnancy and chemotherapy. It also exhibits antioxidant and antibacterial properties, though human data are less robust for these effects. Anti-inflammatory effects may require several weeks of consistent use, while nausea relief can occur within 30–60 minutes. The clinical significance of anti-inflammatory effects is notable in chronic inflammatory conditions.
How it works
Ginger CO₂ extract exerts its effects through several biological pathways. Its anti-inflammatory action involves inhibiting the NF-κB and COX-2 pathways, reducing pro-inflammatory cytokines like TNF-α, IL-6, and CRP. For digestive support, it modulates serotonin receptors and gastrointestinal motility. Gingerols and shogaols are the primary bioactive compounds targeting these pathways. Gingerols are rapidly absorbed, with peak plasma concentrations within 1–2 hours. Shogaols, formed from gingerols during processing, are also bioavailable but have different pharmacokinetics. These compounds interact with the immune system to reduce systemic inflammation and enhance motility in the gastrointestinal tract.
Side effects
Ginger is generally recognized as safe (GRAS) by the FDA at typical doses. Common side effects include mild gastrointestinal discomfort such as heartburn and diarrhea. Uncommon side effects (1-5%) may include allergic reactions and mild headaches. Rare side effects (<1%) include severe allergic reactions and, very rarely, arrhythmia. Ginger may potentiate anticoagulants like warfarin, requiring caution. Contraindications include gallstones, bleeding disorders, and high doses during pregnancy. It is safe in pregnancy at typical doses for nausea; however, consulting a healthcare provider is advised for high doses or chronic use. Monitor for interactions with blood thinners and discontinue use if severe adverse effects occur.
Dosage
For digestive support, a minimum effective dose is 250–500 mg of standardized extract per day. For anti-inflammatory effects, the optimal dosage range is 500–1000 mg per day. The maximum safe dose is up to 4 g per day in divided doses for short-term use; long-term safety above 2 g/day is less established. It is best taken with meals to reduce gastrointestinal side effects. CO₂ extracts are more concentrated, so follow manufacturer guidelines (e.g., 25 mg of gingerols/shogaols per capsule). Absorption is enhanced by food, and CO₂ extracts may have improved bioavailability of lipophilic compounds.
FAQs
Is ginger CO₂ extract safe?
Ginger is safe for most adults at recommended doses. Monitor for interactions with blood thinners and consult a healthcare provider if you have any concerns.
When and how should I take ginger CO₂ extract?
Take with meals to minimize GI discomfort. Consistent daily use is recommended for chronic benefits. Follow manufacturer guidelines for CO₂ extract concentrations.
How long does it take to see results?
Reduced nausea may occur within hours. Anti-inflammatory effects may take several weeks of consistent use. Individual results may vary.
Is ginger CO₂ extract a cure-all?
Ginger is not a cure-all; benefits are moderate and dose-dependent. CO₂ extracts may offer higher concentrations of certain compounds but are not inherently superior to other forms.
Research Sources
- https://www.mdpi.com/1420-3049/30/5/1013 – This experimental study focuses on the supercritical CO₂ extraction of oleoresin from Peruvian ginger. The key finding is that this extraction method yields high concentrations of bioactive compounds, specifically gingerols and shogaols, from the ginger rhizome. While the study provides valuable insights into extraction methodology, it lacks human clinical data.
- https://pubmed.ncbi.nlm.nih.gov/32763761/ – This systematic review and meta-analysis of RCTs examined the anti-inflammatory effects of ginger. The key finding was that ginger significantly lowers CRP, hs-CRP, and TNF-α levels, with a CRP reduction of 0.5–1.5 mg/L (p < 0.05). The study's limitations include heterogeneity in dosing and extract types, but it is considered high quality due to its robust methodology and clear effect sizes.
- https://japsonline.com/admin/php/uploads/3840_pdf.pdf – This systematic review and meta-analysis investigated ginger's antibacterial effects. The study found that ginger extracts, including methanol and CO₂ extracts, exhibit significant antibacterial activity against common pathogens such as *S. aureus*, *K. pneumoniae*, *P. mirabilis*, and *E. coli*. However, the study's clinical relevance in humans is limited due to the lack of human RCTs.
- https://radiantlifecatalog.com/superpure-ginger-extract/ – This is a product page for Superpure Ginger Extract. It highlights the benefits of the product, including its high concentration of gingerols and shogaols, and its use for digestive support and anti-inflammatory effects. It does not contain primary research data.
- https://thesynergycompany.com/products/ginger – This is a product page for ginger supplements. It highlights the benefits of the product, including its use for digestive support and anti-inflammatory effects. It does not contain primary research data.
