Superpure Licorice Root Extract
Also known as: Glycyrrhiza glabra, Licorice root, Licorice extract
Overview
Licorice root, derived from the *Glycyrrhiza glabra* plant, is a widely recognized herbal supplement with a history of use in traditional medicine. It is characterized by the presence of glycyrrhizic acid (GA) and licorice flavonoids (LF), which contribute to its therapeutic effects. Licorice root is available in various forms, including capsules, teas, and extracts. It is primarily used for its anti-inflammatory and antioxidant properties, particularly in managing gastrointestinal issues such as ulcers and inflammatory bowel diseases. Emerging research also explores its potential benefits in neurodegenerative diseases and cancer. While the evidence base is still developing, several high-quality systematic reviews and meta-analyses support its efficacy in specific conditions like ulcerative colitis and its effects on blood pressure. However, caution is advised due to potential side effects associated with glycyrrhizic acid.
Benefits
Licorice root extract shows promise in managing ulcerative colitis, as indicated by preclinical studies, though human trials are needed for confirmation. A systematic review and meta-analysis supports this potential. Interventions with glycyrrhizic acid (GA) have been shown to increase systolic and diastolic blood pressure, while licorice flavonoids (LF) do not have a significant effect on blood pressure. This suggests that deglycyrrhizinated licorice (DGL) may be preferable for individuals concerned about blood pressure. Secondary benefits include potential neuroprotective effects and general anti-inflammatory action. The benefits are most pronounced in individuals with gastrointestinal issues seeking anti-inflammatory support. The increase in blood pressure due to GA is statistically significant, but the clinical significance may vary among individuals.
How it works
Licorice root's therapeutic effects are attributed to its anti-inflammatory and antioxidant properties, primarily mediated by glycyrrhizic acid (GA) and licorice flavonoids (LF). The mechanisms of action involve modulation of various biological pathways, including those related to inflammation and oxidative stress. Glycyrrhizic acid interacts with molecular targets such as GFI1B, MYLK, and RSU1. It affects the gastrointestinal system by soothing irritation and reducing inflammation. Research also suggests potential influence on neurological pathways. The bioavailability of licorice compounds varies depending on the form and preparation, affecting its overall efficacy.
Side effects
Licorice root is generally considered safe when used appropriately, but high doses or prolonged use can lead to adverse effects. The most common side effect is increased blood pressure, primarily associated with glycyrrhizic acid (GA). Other potential side effects include edema and hypokalemia. Rare but severe cases of hypokalemia can lead to muscle weakness or cardiac arrhythmias. Licorice may interact with diuretics, corticosteroids, and other medications that affect potassium levels, potentially exacerbating hypokalemia. It is contraindicated in pregnancy, breastfeeding, and individuals with severe hypertension or kidney disease. Caution is advised for individuals with cardiovascular conditions. Monitoring blood pressure and potassium levels is recommended during prolonged use.
Dosage
The minimum effective dose of licorice root is not well established and varies depending on the condition being treated. Typical dosage ranges from 500 mg to 2 grams per day, depending on the specific preparation and condition. It is generally recommended not to exceed 2 grams per day for extended periods due to potential blood pressure effects. Licorice root is best taken with meals to reduce gastrointestinal side effects. Common forms include capsules and teas. Bioavailability may be enhanced with certain preparations or when combined with other herbs. No specific cofactors are required, but monitoring blood pressure and potassium levels is advisable.
FAQs
Should I monitor anything while taking licorice root?
If using glycyrrhizic acid-rich products, regular blood pressure monitoring is advisable due to the potential for increased blood pressure.
What are the safety precautions when using licorice root?
Avoid high doses or prolonged use of licorice root without medical supervision to minimize the risk of adverse effects such as increased blood pressure and hypokalemia.
When is the best time to take licorice root?
Take licorice root with meals to minimize potential gastrointestinal side effects and improve absorption of its active compounds.
How long does it take to see results from licorice root?
The time to notice benefits varies based on the condition being treated; it may take several weeks of consistent use to observe noticeable improvements.
Is licorice root a cure-all for digestive issues?
No, licorice root is not a cure-all. While it can help with certain digestive issues, it may exacerbate hypertension in some individuals and should be used with caution.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/35671864/ – This systematic review with meta-analysis explores the potential of licorice extract in managing ulcerative colitis. The study suggests that licorice extract may be beneficial for ulcerative colitis, but emphasizes the need for more human trials to confirm these findings and establish optimal usage guidelines.
- https://www.sciencedirect.com/science/article/abs/pii/S0149763423004219 – This study investigates the anti-inflammatory activity and safety of compound glycyrrhizin in ulcerative colitis. The research highlights the potential therapeutic benefits of glycyrrhizin in managing ulcerative colitis, while also underscoring the importance of further research to fully understand its effects and safety profile.
- https://www.sciencedirect.com/science/article/pii/S1756464622000743 – This systematic review focuses on the anti-inflammatory activity and safety of glycyrrhizin in ulcerative colitis. The review emphasizes the need for further research to fully understand its effects and safety profile in treating ulcerative colitis.
- https://pubmed.ncbi.nlm.nih.gov/39519602/ – This meta-analysis examines the effects of glycyrrhizic acid and licorice flavonoids on blood pressure. The study found that glycyrrhizic acid increases blood pressure, while licorice flavonoids have no significant effect, suggesting that deglycyrrhizinated licorice (DGL) may be a preferable option for individuals concerned about blood pressure.
- https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0035-1558227.pdf – This article discusses the use of herbal medicine in treating inflammatory bowel disease, including ulcerative colitis. It highlights the potential benefits of various herbal remedies, including licorice, in managing symptoms and improving the quality of life for patients with inflammatory bowel disease.