Superpure Pelargonium Sidoides Root Extract
Also known as: Pelargonium sidoides, African Geranium, Umckaloabo, EPs 7630
Overview
Pelargonium sidoides, commonly known as African Geranium or Umckaloabo, is a plant native to South Africa. Its root extract, often referred to as EPs 7630, is used medicinally, primarily for treating acute respiratory tract infections. The extract is known for its antiviral and immunomodulatory effects, making it a popular herbal supplement for conditions like bronchitis and coughs. It is available in various forms, including capsules and syrups. Research suggests that Pelargonium sidoides extract can reduce the duration and severity of acute bronchitis and coughs, with benefits typically manifesting within a few days of treatment initiation. While generally considered safe, gastrointestinal complaints and hypersensitivity reactions are the most frequently reported side effects. More research is needed to fully understand its effects and potential applications.
Benefits
Pelargonium sidoides extract has demonstrated effectiveness in reducing the duration and severity of acute bronchitis and coughs. A systematic review indicated its effectiveness compared to placebo in treating acute bronchitis. Studies have shown that the extract can lead to earlier remission of cough and improvement in self-rated measures. It appears effective across various age groups, including children and adults. There is also some evidence suggesting potential benefits in improving symptoms of other viral respiratory infections. While specific effect sizes vary, the clinical significance is reflected in earlier symptom resolution.
How it works
Pelargonium sidoides extract is believed to exert its effects through antiviral and immunomodulatory properties. It interacts with the immune system to enhance its response to viral infections, potentially influencing viral replication and immune response pathways. While specific molecular targets are not well-defined, the extract's mechanism of action involves modulating the body's immune response to combat respiratory infections. Limited information is available on the detailed absorption and bioavailability of the extract.
Side effects
Pelargonium sidoides is generally considered safe when used as directed. The most common side effects include gastrointestinal complaints such as nausea, diarrhea, or stomach upset, and hypersensitivity reactions. Uncommon and rare side effects are not well-documented. There is limited information on potential drug interactions, so caution should be exercised when combining it with other medications. Specific contraindications are not well-defined, but caution is advised in pregnancy and breastfeeding due to limited data. Use in children and elderly populations should be monitored due to potential sensitivity. It is important to discontinue use and consult a healthcare provider if any adverse reactions occur.
Dosage
The typical minimum effective dose of Pelargonium sidoides extract is 20-30 mg per day for adults. The optimal dosage range is generally between 20-60 mg per day, depending on the specific formulation and the condition being treated. There is limited data on the maximum safe dose, but doses above 60 mg per day are not commonly recommended. Dosing should be consistent and ideally taken at the same time each day. It is available in various forms, including capsules and syrups. Absorption may be influenced by gastrointestinal health. No specific cofactors are required for its efficacy.
FAQs
How should I take Pelargonium sidoides?
Follow the recommended dosage on the product label, typically 20-60 mg per day. Consistent dosing is recommended for optimal effects. Consult a healthcare provider before starting treatment, especially if you have underlying health conditions.
Is Pelargonium sidoides safe?
It is generally safe but can cause gastrointestinal side effects. Use cautiously in sensitive populations, such as pregnant or breastfeeding women, and monitor for any adverse reactions. Discontinue use and consult a healthcare provider if side effects occur.
How long does it take to see results?
Improvement in respiratory symptoms can typically be expected within a few days of starting treatment. It is not a cure for viral infections but can help alleviate symptoms and reduce the duration of illness.
Can Pelargonium sidoides cure a cold?
Pelargonium sidoides is not a cure for colds or other viral infections. However, it can help alleviate symptoms such as cough and bronchitis and may reduce the duration of the illness.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/18222667/ – This systematic review found Pelargonium sidoides to be effective compared to placebo in treating acute bronchitis. The review provides encouraging evidence based on available data, suggesting its potential as a treatment option for this condition. The study highlights the need for further research to fully elucidate its mechanisms and optimize its use.
- https://mrmjournal.org/index.php/mrm/article/view/868 – This study demonstrated that the extract EPs 7630 reduces the burden and leads to earlier remission of cough. The benefits were reflected in self-rated measures, indicating an improvement in the patients' subjective experience of their symptoms. The findings suggest that EPs 7630 can be a valuable tool in managing acute cough.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1335309/full – This research explores the pharmacological properties of Pelargonium sidoides, focusing on its antiviral and immunomodulatory effects. The study provides insights into the mechanisms by which the extract can help in reducing the severity of respiratory infections. The findings support its traditional use and suggest potential for further development as a therapeutic agent.
- https://www.dovepress.com/pelargonium-sidoides-extract-eps-7630-a-review-of-its-clinical-efficac-peer-reviewed-fulltext-article-IJGM – This review summarizes the clinical efficacy of Pelargonium sidoides extract EPs 7630, highlighting its benefits in treating respiratory tract infections. The article provides a comprehensive overview of the available evidence, supporting its use as an effective and safe treatment option. The review emphasizes the importance of considering the extract as part of a holistic approach to managing respiratory health.
- https://medcraveonline.com/JLPRR/eps-7630-in-acute-respiratory-tract-infections-ndash-a-systematic-review-and-meta-analysis-of-randomized-clinical-trialsnbsp.html – This systematic review and meta-analysis showed encouraging evidence for the efficacy and safety of Pelargonium sidoides extract EPs 7630 in acute respiratory tract infections. The study synthesizes data from multiple randomized clinical trials, strengthening the evidence base for its use. The findings support the extract's potential as a valuable treatment option for these common infections.