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Tamaflex

Also known as: TamaFlex, NXT15906F6, Tamarindus indica seed extract and Curcuma longa rhizome extract blend

Overview

TamaFlex is a proprietary botanical dietary supplement formulated from extracts of *Tamarindus indica* (tamarind) seeds and *Curcuma longa* (turmeric) rhizome. It is primarily used to alleviate joint pain and improve musculoskeletal function, particularly in individuals with osteoarthritis. The formulation contains a minimum of 65% proanthocyanidins (from tamarind) and 3% total curcuminoids (from turmeric), both known for their anti-inflammatory and antioxidant properties. TamaFlex is available in capsule or tablet form and is typically taken once daily. Research suggests that TamaFlex may reduce inflammation and improve joint health, but further comprehensive studies are needed to confirm these effects and establish long-term safety. The available evidence consists mainly of small-scale randomized controlled trials (RCTs) with some methodological limitations, indicating an emerging but not fully established level of research maturity.

Benefits

TamaFlex has demonstrated potential benefits in reducing knee joint pain and improving musculoskeletal function in individuals with mild to moderate osteoarthritis. Studies have shown significant improvements in WOMAC scores, indicating reduced pain and enhanced joint function within 30 days of supplementation. Additionally, TamaFlex may reduce inflammation, as indicated by decreased levels of high-sensitivity C-reactive protein (hs-CRP). These benefits are primarily observed in adults with osteoarthritis. While specific effect sizes are not widely reported, the clinical significance is noted in improved joint function and pain reduction. The quality of evidence is considered moderate, based on small-scale RCTs.

How it works

TamaFlex's mechanism of action primarily involves anti-inflammatory pathways. The curcuminoids in turmeric may target NF-κB and other inflammatory pathways, while proanthocyanidins from tamarind may exert antioxidant effects. This combination potentially reduces pro-inflammatory cytokines and modulates inflammatory biomarkers like hs-CRP, affecting both the musculoskeletal and immune systems. The synergistic effect of these compounds contributes to reduced inflammation and improved joint health. Specific data on the absorption and bioavailability of TamaFlex components is limited, but the lipophilic nature of curcumin suggests that its absorption may be enhanced with fatty meals.

Side effects

TamaFlex is generally considered safe based on available studies, but comprehensive safety data is limited. Common side effects are not well-documented, but potential gastrointestinal upset, similar to other botanical supplements, may occur. Rare side effects have not been reported. Due to curcumin's anti-coagulant properties, potential interactions with blood thinners exist, necessitating caution for individuals on such medications. While no specific contraindications are noted, caution is advised during pregnancy and breastfeeding due to a lack of safety data. Elderly individuals may require monitoring due to potential interactions with other medications. It is important to consult with a healthcare provider before use, especially for those with pre-existing conditions or taking other medications.

Dosage

The minimum effective dose of TamaFlex, as used in clinical trials, is 250 mg per day. Optimal dosage ranges have not been established beyond this studied dose. The maximum safe dose is also undefined. TamaFlex is typically taken once daily after breakfast. It is commonly available in capsule or tablet form. Due to the lipophilic nature of curcumin, bioavailability may be enhanced when taken with fatty meals. There are no specified required cofactors. It is crucial not to exceed the recommended dosage without consulting a healthcare professional.

FAQs

Is TamaFlex safe to use?

TamaFlex is generally considered safe, but comprehensive safety data is limited. Consult a healthcare provider before use, especially if you have pre-existing conditions or are taking other medications.

When is the best time to take TamaFlex?

It is recommended to take TamaFlex once daily after breakfast to potentially enhance the absorption of curcuminoids due to the presence of fats in the meal.

How long does it take to see results with TamaFlex?

Clinical trials have shown improvements in joint function and reduced pain within 30 days of supplementation with TamaFlex.

Can TamaFlex cure osteoarthritis?

TamaFlex is not a cure for osteoarthritis but may help alleviate symptoms such as joint pain and inflammation, improving overall joint function.

Are there any known drug interactions with TamaFlex?

Due to the curcumin content, TamaFlex may interact with blood thinners. Consult your healthcare provider if you are taking anticoagulant medications.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC9514497/ – This in vitro and preclinical study explores the synergistic anti-inflammatory effects of a tamarind and curcumin blend. The research provides foundational evidence for the potential mechanisms by which the blend reduces pain and inflammation at a cellular level, suggesting a combined effect that could be beneficial for joint health.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10284097/ – This randomized, double-blind, placebo-controlled trial evaluated the efficacy of NXT15906F6 (TamaFlex) in subjects with knee osteoarthritis. The study found that TamaFlex reduced joint pain and improved musculoskeletal functions, suggesting it could be a beneficial supplement for managing osteoarthritis symptoms, although larger studies are needed for confirmation.
https://foodandnutritionresearch.net/index.php/fnr/article/view/9268 – This study investigates the effects of a proprietary blend of tamarind and curcumin on musculoskeletal function in adults with osteoarthritis. The research indicates that the blend improves joint function and reduces pain, highlighting its potential as a natural alternative for managing osteoarthritis symptoms; however, the findings are limited by the study's small sample size and short duration.
https://journals.sagepub.com/doi/full/10.1177/2397847317749240 – This randomized, double-blind, placebo-controlled trial assesses the impact of a tamarind seed extract on knee joint pain and function in individuals with osteoarthritis. The study reveals significant improvements in WOMAC scores and reduced inflammation, suggesting that tamarind seed extract can be an effective supplement for alleviating osteoarthritis symptoms, though the results are constrained by the study's limited sample size and duration.
https://www.naturalhealthresearch.org/a-proprietary-blend-of-tamarind-and-curcumin-improves-musculoskeletal-function-in-adults-with-osteoarthritis/ – This research highlights the benefits of a proprietary blend of tamarind and curcumin for improving musculoskeletal function in adults with osteoarthritis. The study demonstrates that the blend can lead to reduced pain and enhanced joint function, indicating its potential as a natural remedy for managing osteoarthritis symptoms; however, further research with larger sample sizes is necessary to validate these findings.