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Tamaflex Proprietary Blend

Q: How long does it take to see benefits?

Improvements were observed as early as day 5 of supplementation.

Q: Is it safe?

TamaFlex™ is well-tolerated, with no significant adverse effects reported in studies.

Q: Can it be used with other medications?

No detailed information on drug interactions is available, making it prudent to consult healthcare providers.

Q: How should it be taken?

The supplement should be taken daily after breakfast for optimal results.

Q: What should I expect?

Significant reductions in joint pain and improvements in musculoskeletal function are anticipated.

Also known as: TamaFlex, NXT15906F6, Tamarindus indica, Curcuma longa, TamaFlex™ (NXT15906F6)

Overview

TamaFlex™ is a proprietary blend consisting of standardized extracts from *Tamarindus indica* (tamarind seeds) and *Curcuma longa* (turmeric rhizome). *Tamarindus indica* originates from tropical Africa, while *Curcuma longa* is widely cultivated in India and Southeast Asia. The blend is primarily utilized for pain relief and enhancement of musculoskeletal function in individuals with osteoarthritis (OA). Its composition includes a minimum of 65% proanthocyanidins from tamarind seeds and 3% total curcuminoids from turmeric. Clinical evidence, arising from multiple randomized controlled trials (RCTs), supports its efficacy in improving joint health and function, particularly among adults aged 40 to 70 with mild to moderate knee osteoarthritis (KOA). The promising results from these studies highlight a marked reduction in pain and improved physical performance metrics.

Benefits

TamaFlex™ demonstrates significant reductions in pain and functional limitations associated with knee osteoarthritis. Key benefits from clinical trials include a 19.79% reduction in WOMAC scores by day 5, escalating to 38.11% by day 30, along with a 33.10% decrease in VAS pain scores. Secondary improvements include a 32.48% increase in Six Minute Walk Test scores and a 5.35% enhancement in knee flexion range of motion. Furthermore, reductions in serum hs-CRP and CTX-II levels indicate decreased systemic inflammation and cartilage breakdown. The studies indicate that the most advantageous populations for TamaFlex™ include adults aged 40-70 with a BMI of 20-29, showcasing statistically significant outcomes with p-values < 0.001 from well-structured RCTs.

How it works

The effectiveness of TamaFlex™ can be attributed to the anti-inflammatory and antioxidant properties of its primary components. Curcuminoids from *Curcuma longa* inhibit inflammatory signaling pathways such as NF-κB, while proanthocyanidins from *Tamarindus indica* exhibit similar anti-inflammatory actions. This synergistic interaction primarily targets the musculoskeletal and immune systems, leading to decreased inflammation, reduced severity of joint pain, and improved physical function. Additionally, the proprietary formulation may enhance the bioavailability of its active compounds, although specific absorption data is still limited.

Side effects

TamaFlex™ has a strong safety profile, with no significant adverse effects reported in clinical studies. No common, rare, or uncommon side effects were noted, and the supplement was well-tolerated across all evaluated populations. Parameters such as clinical chemistry, hematology, and vital signs remained stable, indicating that it does not induce harmful physiological changes. While specific drug interactions and contraindications were not detailed, the absence of reported adverse events suggests it may be safe for use in healthy adults. However, further investigation into long-term safety and interaction with concurrent medications is warranted. Special populations, including children, pregnant women, and individuals with severe OA, have not been adequately studied, thus limiting generalizability in those groups.

Dosage

The recommended minimum effective dose for TamaFlex™ is 250 mg per day, as evidenced by clinical trials. While an optimal dosage range is not fully established, this dose has consistently shown significant efficacy in improving joint function and alleviating pain. Daily supplementation should occur after breakfast, and studies suggest continued use over a 30-day period for maximum benefits. The proprietary blend is available in capsule form; however, specific information regarding upper dosage limits or safety thresholds remains undefined in the literature. Although absorption-enhancing formulation aspects are implied, detailed absorption factors are yet to be disclosed for this proprietary blend.

FAQs

How long does it take to see benefits?

Improvements were observed as early as day 5 of supplementation.

Is it safe?

TamaFlex™ is well-tolerated, with no significant adverse effects reported in studies.

Can it be used with other medications?

No detailed information on drug interactions is available, making it prudent to consult healthcare providers.

How should it be taken?

The supplement should be taken daily after breakfast for optimal results.

What should I expect?

Significant reductions in joint pain and improvements in musculoskeletal function are anticipated.

Research Sources

https://www.naturalhealthresearch.org/a-proprietary-blend-of-tamarind-and-curcumin-improves-musculoskeletal-function-in-adults-with-osteoarthritis/ – This research evaluated the effects of TamaFlex™ on adults with knee osteoarthritis. The study demonstrated significant improvements in WOMAC and VAS scores, indicating enhanced joint function and pain relief.
https://foodandnutritionresearch.net/index.php/fnr/article/view/9268 – A randomized controlled trial assessing the efficacy of TamaFlex™ found notable reductions in inflammatory markers and improved functional performance over a 30-day treatment period.
https://onlinelibrary.wiley.com/doi/pdf/10.1155/2022/2226139 – This study highlighted the impact of the proprietary blend in improving musculoskeletal symptoms in adults with knee osteoarthritis, emphasizing the need for further long-term studies.