The Balance Blend
Also known as: The Balance Blend, Reishi, Lingzhi, Lion’s Mane, Maitake, Shiitake, Functional mushroom blend, Adaptogenic mushroom blend, Immunomodulatory mushroom blend, Ganoderma lucidum, Hericium erinaceus, Grifola frondosa, Lentinula edodes Blend
Overview
The Balance Blend is a proprietary dietary supplement composed of extracts from four medicinal mushrooms: *Ganoderma lucidum* (Reishi), *Hericium erinaceus* (Lion’s Mane), *Grifola frondosa* (Maitake), and *Lentinula edodes* (Shiitake). These mushrooms are traditionally used in East Asian medicine and are rich in bioactive compounds such as polysaccharides, triterpenoids, and erinacines. The blend is marketed to support hormonal balance, immune function, cognitive health, stress relief, and sleep quality, particularly for women's health. It leverages the immunomodulatory, neuroprotective, and adaptogenic properties of its individual components. While individual mushrooms, especially Reishi and Lion's Mane, have been extensively studied, research specifically on the combined proprietary blend is limited, with most evidence derived from studies on the individual ingredients.
Benefits
The Balance Blend offers several evidence-based benefits, primarily stemming from its individual mushroom components. For immune support, Reishi mushrooms, rich in polysaccharides and triterpenoids, enhance immune cell activity and cytokine production, improving immune resilience. Lion’s Mane significantly improves cognitive function by promoting neurogenesis in hippocampal regions, with randomized controlled trials (RCTs) showing statistically significant improvements in recognition memory in individuals with mild cognitive impairment (MCI) over 8-16 weeks. Secondary benefits include improved mood and reduced anxiety, likely due to the neuroprotective and adaptogenic effects of Lion’s Mane and Reishi, though direct clinical evidence for the blend is limited. Anecdotal evidence suggests benefits for hormonal balance, particularly for menopausal symptoms, but robust clinical trials are needed. Women, especially those experiencing menopause or mild cognitive decline, may particularly benefit from the blend's hormonal and cognitive support properties. For Lion's Mane in MCI, improvements in cognitive scores were statistically significant (p < 0.05) with moderate effect sizes, indicating clinically meaningful benefits.
How it works
The Balance Blend exerts its effects through several primary biological pathways. Immune modulation is achieved by polysaccharides in Reishi and Maitake, which stimulate macrophages, natural killer cells, and cytokine production, thereby enhancing innate immunity. Lion’s Mane contributes to neurogenesis through its active compounds, hericenones and erinacines, which promote the synthesis of nerve growth factor (NGF). This process facilitates hippocampal neurogenesis and improves synaptic plasticity, leading to enhanced cognitive function. The blend interacts with the immune system, the central and peripheral nervous systems, and potentially the endocrine system. Key molecular targets include NGF pathways (Lion’s Mane) and cytokine signaling (Reishi). While mushroom polysaccharides are generally poorly absorbed, the use of standardized extracts for bioactive compounds aims to improve bioavailability.
Side effects
The Balance Blend is generally considered safe with a low incidence of adverse effects when consumed at recommended doses. Common side effects, reported in over 5% of users, include mild gastrointestinal discomfort such as bloating or nausea. Uncommon side effects, occurring in 1-5% of individuals, involve allergic reactions, particularly in those sensitive to mushrooms. Rare side effects, affecting less than 1% of users, may include elevated liver enzymes, especially with high doses of Reishi. The blend may interact with certain medications; caution is advised for individuals taking immunosuppressants or anticoagulants due to potential interactions. Contraindications include immunocompromised individuals or those on immune-modulating drugs, who should consult a healthcare provider before use. Pregnant or breastfeeding women should avoid this blend due to insufficient safety data in these specific populations.
Dosage
The optimal dosage for The Balance Blend varies depending on the standardization of its extracts. For individual mushroom extracts, typical effective doses range from 500 mg to 3 g daily per mushroom. Proprietary blends commonly provide a total of 1-2 g of combined mushroom extract daily. The maximum safe dose is generally considered to be up to 3-5 g daily of combined extracts, with no adverse effects commonly reported within this range. Consistent daily intake is recommended for best results, with cognitive benefits often observed after several weeks of continuous use. For optimal efficacy, extracts standardized for polysaccharides and triterpenoids are preferred. Taking the supplement with food may improve absorption and help mitigate potential gastrointestinal discomfort. No specific cofactors are required, but a generally nutritious diet can support overall health and potentially enhance the blend's effects.
FAQs
Is The Balance Blend safe for long-term use?
Current evidence supports its safety for several months; however, long-term studies specifically on the blend are limited. Consult a healthcare professional for extended use.
How soon will I notice benefits?
Cognitive and mood benefits may become noticeable after 8-12 weeks of consistent use. Immune effects can vary but generally require regular intake over several weeks.
Can it replace hormone therapy?
No, The Balance Blend is not a substitute for prescribed hormone therapies. It may support hormonal balance but should not be used as a replacement for medical treatment.
Are there any known allergies?
Individuals with known allergies to mushrooms should avoid this blend. If you experience allergic symptoms, discontinue use and consult a doctor.
Can it be taken with medications?
Consult a healthcare provider before taking this blend, especially if you are on immunosuppressants or blood thinners, due to potential drug interactions.
Research Sources
- https://eprints.soton.ac.uk/447668/1/O_Connor_David_final_thesis.pdf – This source is a thesis that discusses various aspects of medicinal mushrooms, including their potential benefits for mood and anxiety. While it doesn't directly study 'The Balance Blend', it provides background on the adaptogenic and neuroprotective effects of components like Lion's Mane and Reishi, which are relevant to the blend's reported benefits.
- https://www.eversiowellness.com/blogs/news/the-balance-blend-for-women-s-health – This blog post from Eversion Wellness discusses 'The Balance Blend' and its purported benefits for women's health, including hormonal balance. It suggests anecdotal and preliminary evidence for hormone regulation, particularly for menopausal symptoms, but notes the lack of robust clinical trials specifically on the blend.
- https://www.eversiowellness.com/blogs/news/are-mushroom-supplements-good-for-you-heres-what-experts-say – This article from Eversion Wellness provides a general overview of mushroom supplements and their benefits. It touches upon the immunomodulatory, neuroprotective, and adaptogenic properties of medicinal mushrooms, supporting the claims made for the individual components within 'The Balance Blend'.
- https://www.menocil.com/supplements/menocil-vs-menophix – This source compares two supplements, Menocil and Menophix, which are likely related to women's health and hormonal balance. While not directly about 'The Balance Blend', it provides context for supplements targeting similar health concerns, particularly menopausal symptoms.
- https://www.healthline.com/health/healthy-sleep/essential-oils-for-sleep – This Healthline article discusses essential oils for sleep. While not directly related to 'The Balance Blend' or medicinal mushrooms, it highlights the broader context of natural remedies for sleep quality, which is one of the claimed benefits of the blend.
- https://www.planttherapy.com/blogs/blog/sex-and-essential-oils – This Plant Therapy blog post discusses essential oils and their potential uses, including for sexual health. This source is not directly relevant to 'The Balance Blend' or medicinal mushrooms, but it falls under the general category of natural health and wellness products.
Supplements Containing The Balance Blend
Recommended Articles

Glutamine Dosage for Gut Health: A Guide
Glutamine supports gut health with a recommended dosage of 5-30 grams per day, available in various supplement forms.

2025's Top Vegan Protein Powders: A Buyer's Guide
In 2025, the best vegan protein powders are third-party tested, ensuring purity, safety, and high nutritional content.

Top Ingredients for Healthy Weight Management
Dietary fiber, protein, omega-3 fatty acids, and water are crucial for managing a healthy weight.

Top Immune Support Ingredients: What Works?
Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.