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Thlaspi Herb Extract

Also known as: Thlaspi arvense L., Field pennycress, Stinkweed, Bai Jiang Cao, Thlaspi arvense

Overview

Thlaspi arvense, commonly known as Field Pennycress or Stinkweed, is a flowering plant traditionally utilized in Tibetan and Chinese medicine. The extract, typically derived from the aerial parts of the plant, is primarily investigated for its potential in managing hyperuricemia and inflammatory conditions such as ulcerative colitis. Its therapeutic properties are attributed to the presence of various phytochemicals, including flavonoids like isovitexin and orientin, and glucosinolates such as sinigrin. While traditional uses suggest a range of benefits, current scientific understanding of Thlaspi arvense extract is in its early stages, with research predominantly confined to preclinical and animal model studies. There is a notable absence of human clinical trials, systematic reviews, or meta-analyses specifically focusing on this extract, indicating that its efficacy and safety in humans are not yet established. Despite this, the preliminary findings from animal studies show promise for its application in uric acid reduction and anti-inflammatory responses.

Benefits

Research on Thlaspi arvense extract has identified two primary potential benefits, though these are currently supported only by animal model studies: 1. **Uric Acid Reduction:** In a rat model of hyperuricemia, Thlaspi arvense extract demonstrated a significant ability to lower serum uric acid levels. Its efficacy was comparable to that of benzbromarone, a standard pharmaceutical used for uric acid reduction. This suggests a potential role in managing conditions like gout, but human data is needed to confirm this effect. 2. **Anti-inflammatory Effects:** Studies in a mouse model of DSS-induced ulcerative colitis showed that oral administration of Thlaspi arvense extract effectively reduced key indicators of inflammation, including disease activity index, body weight loss, splenomegaly, and colon shortening. The observed anti-inflammatory effects were comparable to those achieved with 5-aminosalicylic acid (5-ASA), a conventional treatment for ulcerative colitis. This indicates a potential for modulating inflammatory responses, particularly in the gut. It is crucial to note that these benefits have only been observed in animal models. There are no clinical effect sizes, confidence intervals, or human trials available to substantiate these claims in humans. Therefore, while promising, these findings are preliminary and do not yet support therapeutic use in humans.

How it works

The proposed mechanisms of action for Thlaspi arvense extract involve multiple biological pathways. Its uric acid-lowering effect is believed to stem from the modulation of genes and pathways critical to uric acid metabolism, as indicated by mRNA sequencing and network pharmacology analyses in animal studies. The anti-inflammatory properties appear to be mediated by the suppression of TNF inflammatory pathways and a beneficial modulation of gut microbiota composition, leading to a reduction in systemic and colonic inflammation. The extract contains key phytochemicals such as isovitexin, orientin, sinigrin, cynaroside, and apigenin, which are known for their antioxidant and anti-inflammatory activities. However, specific details regarding the absorption, distribution, metabolism, and excretion (ADME) of these compounds, as well as their overall bioavailability, are not yet well characterized.

Side effects

Currently, there is a significant lack of human safety data and reported adverse events for Thlaspi arvense extract. The available animal studies have not indicated significant toxicity at the doses tested, suggesting a potentially favorable safety profile in preclinical settings. However, this does not directly translate to human safety. While traditional use might imply a degree of tolerability, formal toxicology studies, comprehensive drug interaction analyses, and human clinical trials are entirely absent. Consequently, there are no established contraindications or known drug interactions. Users should be aware that the safety profile in humans is largely uncharacterized, and caution is advised until more robust scientific evidence becomes available. Without human data, the severity, frequency, and specific risk factors for potential side effects cannot be determined.

Dosage

Due to the absence of human clinical trials, there are no established human dosing guidelines for Thlaspi arvense extract. The effective doses observed in animal models include 3.5 g/kg of extract in rats for uric acid reduction. In mouse models for colitis, various doses were used, with both low and high ranges demonstrating efficacy, though precise quantification for human translation is not available. It is important to note that extraction methods and the standardization of active components can vary significantly, which would impact the potency and consistency of different preparations. Typical extract preparations mentioned in the literature include aqueous or glycerin-based extractions. Without human data, any self-administration of this extract would be speculative and potentially unsafe. Upper limits and safety thresholds for human consumption are entirely unknown.

FAQs

Is Thlaspi arvense extract clinically proven in humans?

No, current scientific evidence for Thlaspi arvense extract is limited to preclinical and animal model studies. There are no human clinical trials to confirm its efficacy or safety.

Is it safe to use Thlaspi arvense extract?

The safety of Thlaspi arvense extract in humans is not established. While animal studies did not report significant toxicity, formal human safety and toxicology studies are lacking. Caution is advised.

How quickly does Thlaspi arvense extract work?

In animal models, effects were observed within days to weeks, depending on the condition studied. However, the onset of action in humans is unknown due to a lack of clinical data.

Can Thlaspi arvense extract replace standard medical treatments?

No, there is no clinical evidence to support replacing established medical therapies with Thlaspi arvense extract. It should not be used as a substitute for prescribed medications.

Research Sources

  • https://papers.ssrn.com/sol3/Delivery.cfm/8f449563-9357-44ed-9cf5-e603ffe66838-MECA.pdf?abstractid=4380007&mirid=1 – This preclinical study in a rat model of hyperuricemia investigated the effects of Thlaspi arvense extract on serum uric acid levels. The findings indicated that the extract significantly reduced uric acid, comparable to a standard drug, and identified potential active components and gene pathways involved in this effect. The study was well-designed for an animal model, providing moderate quality evidence for its findings.
  • https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1537325/full – This preclinical study utilized a mouse model of DSS-induced ulcerative colitis to evaluate the anti-inflammatory properties of Thlaspi arvense extract. The results showed that the extract effectively ameliorated colitis symptoms and reduced inflammation, with efficacy comparable to 5-aminosalicylic acid. The study's use of biochemical and histological endpoints contributes to its moderate quality.
  • https://ouci.dntb.gov.ua/en/works/4200DpV8/ – This source appears to be a general review or database entry related to molecular mechanisms and therapeutic potential of various herbs, including Thlaspi. While it may summarize potential mechanisms, it does not provide a direct meta-analysis or specific high-quality data on Thlaspi arvense extract, thus offering low quality evidence for specific claims about this plant.

Supplements Containing Thlaspi Herb Extract

Isatis Supreme by Ron Teeguarden's Dragon Herbs
55

Isatis Supreme

Ron Teeguarden's Dragon Herbs

Score: 55/100