Tokoro Yam Rhizome Extract
Also known as: Tokoro Yam Rhizome Extract, Yam, Wild Yam, Chinese Yam, Dioscorea villosa, Dioscorea batatas, Dioscorea spp. (Yam Rhizome Extract)
Overview
Yam rhizome extract, derived from plants in the *Dioscorea* genus, has been traditionally used for various ailments, including menopause symptoms, arthritis, and digestive issues. Recent research explores its potential anticancer and antidiabetic properties. Yams are rich in sterols and other bioactive compounds. While specific research on 'Tokoro Yam' is limited, studies on related *Dioscorea* species provide insights. The available evidence is variable, with a need for more robust systematic reviews and human trials to validate specific health claims. Different species of *Dioscorea* are used, including *Dioscorea villosa* (wild yam) and *Dioscorea batatas* (Chinese yam), each with potentially distinct properties. The extract is available in various forms, including powders and tinctures, and is often marketed as a dietary supplement.
Benefits
Research suggests potential anticancer and antidiabetic effects, primarily based on studies of specific *Dioscorea* species. *Dioscorea villosa* extract has demonstrated pro-inflammatory and cytostatic effects in triple-negative breast cancer cells, indicating potential anticancer properties. *Dioscorea batatas* has shown promise in reducing blood glucose levels in diabetic rats, suggesting antidiabetic effects. Additionally, there is potential for anti-inflammatory and immune-stimulating effects, although more research is needed to confirm these benefits. These benefits may be particularly relevant for women experiencing menopause symptoms and individuals managing diabetes. However, specific effect sizes and the time course of these benefits are not well-documented for Tokoro Yam specifically.
How it works
The mechanism of action for yam rhizome extract varies depending on the specific benefit. In anticancer activity, it involves altering cell cycle progression and hormone receptor activity. For antidiabetic effects, it may enhance insulin sensitivity and reduce oxidative stress. The extract interacts with endocrine and metabolic systems, targeting hormone receptors and cell cycle regulators. However, the absorption and bioavailability of the active compounds are not well-studied. Further research is needed to fully elucidate the mechanisms by which yam rhizome extract exerts its effects.
Side effects
While yam rhizome extract is generally considered safe when used traditionally, specific safety data for Tokoro Yam is lacking. Common side effects are not well-documented, but potential gastrointestinal upset has been reported. Rare side effects are also not well-documented. There is a potential for drug interactions, particularly with diabetes medications or hormone therapies. Due to a lack of safety data, it is contraindicated during pregnancy and breastfeeding. Caution is advised for individuals with hormone-sensitive conditions. It is essential to consult with a healthcare provider before use, especially if pregnant, breastfeeding, or taking medications.
Dosage
There is currently no established minimum effective dose, optimal dosage range, or maximum safe dose for Tokoro Yam Rhizome Extract. Timing considerations and form-specific recommendations are also not available. Absorption factors and required cofactors are not well-studied. Due to the lack of comprehensive research, it is crucial to consult with a healthcare provider to determine an appropriate dosage based on individual health status and intended use. Until more data is available, it is advisable to start with a low dose and monitor for any adverse effects.
FAQs
Is Tokoro Yam Rhizome Extract safe?
Safety data is limited, so use with caution. Consult a healthcare provider before use, especially if pregnant, breastfeeding, or on medications.
How should I take Tokoro Yam Rhizome Extract?
Specific timing and administration guidelines are not available. Consult with a healthcare provider for personalized recommendations.
What results can I expect from taking this supplement?
Expected results are variable based on the intended use. There is no guarantee of universal health benefits without sufficient evidence.
Are there any drug interactions?
Potential interactions exist with diabetes medications or hormone therapies. Consult with a healthcare provider to avoid adverse effects.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8569819/ – This study investigates the pro-inflammatory and cytostatic effects of *Dioscorea villosa* extract on triple-negative breast cancer cells. The findings suggest that the extract can alter cell cycle progression and hormone receptor activity, indicating potential anticancer properties. The research provides a basis for further investigation into the use of *Dioscorea villosa* in cancer treatment.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4632431/ – This study examines the effects of *Dioscorea batatas* powder and extract on blood glucose levels in diabetic rats. The results indicate that both the powder and extract can reduce blood glucose levels, suggesting antidiabetic potential. The research supports the traditional use of *Dioscorea batatas* in managing diabetes.
- https://www.mdpi.com/2072-6643/15/3/656 – This review discusses the potential health benefits of *Dioscorea* species, including their antioxidant, anti-inflammatory, and anticancer properties. It highlights the importance of further research to validate these benefits and identify the active compounds responsible. The review emphasizes the need for clinical trials to confirm the efficacy and safety of *Dioscorea* extracts.
- https://pure.royalholloway.ac.uk/files/28081210/EPrice.pdf – This study focuses on the steroidal sapogenins found in *Dioscorea* species and their potential as precursors for steroid hormone synthesis. It explores the biochemical pathways involved in the production of these compounds and their potential applications in the pharmaceutical industry. The research contributes to a better understanding of the chemical composition and pharmacological properties of *Dioscorea* plants.
- https://www.jkom.org/journal/view.php?number=5080 – This study investigates the effects of wild yam extract on menopausal symptoms in women. The results suggest that wild yam extract may help alleviate some menopausal symptoms, such as hot flashes and night sweats. The research provides evidence for the traditional use of wild yam in managing menopausal symptoms, although further studies are needed to confirm these findings.