Tongkat Ali Fadogia Proprietary Domination Blend
Also known as: Eurycoma longifolia Jack, Tongkat Ali, Malaysian ginseng, Longjack, Fadogia agrestis, Fadogia, Eurycoma longifolia
Overview
Tongkat Ali (Eurycoma longifolia) is a Southeast Asian herb primarily derived from the root, while Fadogia agrestis is a West African shrub extracted from the stem. Both are traditionally used to support male hormonal health, enhance libido, and improve physical performance. Tongkat Ali contains bioactive quassinoids, notably eurycomanone, which inhibits aromatase and reduces cortisol levels. Fadogia contains alkaloids and saponins that stimulate luteinizing hormone (LH), promoting testosterone synthesis. Tongkat Ali has a well-established research base, including human clinical trials, while Fadogia agrestis lacks robust human trials and safety information. Tongkat Ali's effects are supported by randomized controlled trials (RCTs) and systematic reviews, whereas Fadogia's evidence is mostly preclinical or anecdotal. The combination of these herbs is marketed to maximize testosterone levels, energy, and recovery, but no independent clinical trials exist on proprietary blends combining them.
Benefits
Tongkat Ali significantly increases total testosterone levels, enhances erectile function and libido, and reduces cortisol, improving stress and mood. Studies show that 200 mg daily for 6 months improved testosterone and erectile function in men with androgen deficiency. It also improves muscle mass, strength, and endurance and acts as an adaptogen supporting mental clarity. Fadogia agrestis is proposed to increase testosterone by stimulating LH secretion and may enhance libido, sexual performance, and physical endurance. It also has potential anti-inflammatory and recovery benefits post-exercise. However, there are no high-quality human RCTs available to quantify Fadogia's effects or safety. The synergistic potential of combining Tongkat Ali and Fadogia to maximize testosterone levels, libido, energy, and recovery is theorized, but lacks clinical validation.
How it works
Tongkat Ali inhibits the aromatase enzyme, reducing the conversion of testosterone to estrogen, thereby increasing testosterone bioavailability. It also lowers cortisol levels, reducing stress-induced testosterone suppression. Quassinoids, such as eurycomanone, have androgenic activity. Fadogia agrestis stimulates luteinizing hormone (LH) release from the pituitary, which signals the testes to produce more testosterone. Its active constituents are alkaloids and saponins. Tongkat Ali is absorbed as standardized extracts with bioactive compounds, while mechanistic data for Fadogia is primarily from animal studies, with human pharmacodynamics largely unknown.
Side effects
Tongkat Ali is generally well-tolerated in clinical trials at doses of 200-400 mg daily. Rare side effects may include mild insomnia or increased heart rate. Acute toxicity studies show low toxicity at typical doses. No significant drug interactions have been reported, but caution is advised in hormone-sensitive conditions. Safety data for Fadogia agrestis in humans is insufficient, raising concerns about long-term organ effects based on limited preclinical data. Anecdotal reports suggest caution due to its unknown toxicity profile. There are no established contraindications or drug interaction data for Fadogia. No independent safety studies exist on the combination of Tongkat Ali and Fadogia; theoretical risks depend on the individual components. Users should exercise caution and consult healthcare providers before use.
Dosage
For Tongkat Ali, a minimum effective dose is 200 mg/day of a standardized extract (2-3% eurycomanone), with an optimal range of 200-400 mg/day. The maximum safe dose is not well-established, but up to 400 mg/day is commonly used. Effects start within 1-2 weeks, with consistent daily dosing recommended. Standardized root extracts are preferred for consistency. For Fadogia Agrestis, there is no established minimum dose, but 425-850 mg/day of raw powder is common. The maximum safe dose is unknown, and effects are anecdotally reported within 1-3 weeks. Standardization is lacking, and raw powder is the common form. Absorption of Tongkat Ali is enhanced with standardized extracts and may be influenced by co-administration with antioxidants. Adequate hydration and nutrition are generally recommended.
FAQs
Is Tongkat Ali safe for long-term use?
Clinical studies up to 6 months show good safety; long-term data is limited, but no major adverse effects have been reported.
Can Fadogia Agrestis be used safely?
Due to limited human data, caution is advised; more research is needed before recommending routine use.
Does combining Tongkat Ali and Fadogia increase benefits?
Theoretically yes, due to complementary mechanisms, but no clinical trials have confirmed this synergy.
How soon will I see results?
Tongkat Ali effects may appear within 1-2 weeks; Fadogia effects are anecdotal but may take 1-3 weeks.
Are these supplements effective for women?
Limited data; Tongkat Ali may support hormonal balance but is primarily studied in men. Fadogia’s effects in women are unknown.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/33541567/ – A 6-month, double-blind, placebo-controlled RCT with 45 men with androgen deficiency found that 200 mg Tongkat Ali supplementation combined with exercise significantly improved erectile function and total testosterone levels compared to placebo. The study was limited by its small sample size and lack of groups with only exercise or only Tongkat Ali for direct comparison.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6274257/ – A systematic review of Tongkat Ali's pharmacological effects, chemical constituents, and safety data identified key bioactive compounds (quassinoids), documented low toxicity, and highlighted potential for testosterone enhancement and adaptogenic effects. The review calls for more high-quality human trials to further validate the clinical efficacy of Tongkat Ali.
- https://www.livemomentous.com/blogs/all/tongkat-ali-vs-fadogia-agrestis – A comparative analysis of Tongkat Ali and Fadogia Agrestis highlights that Tongkat Ali has robust human data, while Fadogia lacks clinical trials and safety data. Tongkat Ali acts via aromatase inhibition, while Fadogia acts via LH stimulation. The review is limited by the lack of direct clinical trials on Fadogia in humans, relying mostly on preclinical and anecdotal data.
- https://feelsupreme.co.uk/blogs/mastering-wellness/the-benefits-of-combining-tongkat-ali-and-fadogia-agrestis-a-natural-power-duo-1 – This blog post discusses the potential benefits of combining Tongkat Ali and Fadogia Agrestis, suggesting a synergistic effect for maximizing testosterone levels, libido, energy, and recovery. However, it acknowledges the lack of independent clinical trials on proprietary blends combining these two ingredients, emphasizing the need for further research to validate these claims.
- https://synapse.koreamed.org/articles/1139194 – This article likely discusses the effects of Tongkat Ali on testosterone levels and sexual function. Further review of the article is needed to provide a more detailed summary of its key findings and limitations.
Recommended Articles
Top Fertility Supplements for Women in 2025
By 2025, new FDA-approved fertility supplements, emphasizing organic ingredients, have shown significant effectiveness in aiding conception for women in their 30s.
Barcode-Scanner Apps & Supplements: A Reality Check
Barcode-scanner supplement apps vary in accuracy, especially with proprietary blends, but advancements are improving their reliability.
Legal Pre-Workout Supplements for Athletes
Legal pre-workout supplements like those with caffeine, beta-alanine, and creatine can safely enhance athletic performance without failing doping tests.
Top Testosterone Boosters for Cyclists: A Buyer's Guide
For cyclists, choosing testosterone boosters involves finding scientifically-backed, third-party tested products, with top picks including brands like TestoGen and Prime Male.