ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Type Ii Chicken Collagen

Also known as: Type II Collagen, Chicken Native Type II Collagen, UC-II, Undenatured Type II Collagen

Overview

Type II collagen is a protein naturally found in cartilage, particularly abundant in joints. Chicken native type II collagen is derived from chicken cartilage and is used as a dietary supplement primarily for joint health. It is known for its potential anti-inflammatory effects and ability to support joint function, especially in individuals with osteoarthritis. The supplement is available in various forms, including capsules and powders. Research suggests that it may help reduce joint pain and inflammation, making it a popular choice for those seeking natural remedies for joint-related issues. While evidence is generally supportive, the quality of studies varies, and more research is needed to fully understand its long-term effects and optimal usage. It is considered a moderately researched supplement with promising results for joint health.

Benefits

Type II collagen, particularly UC-II, has shown promise in reducing articular pain and inflammation in osteoarthritis patients. Studies using UC-II derived from chicken sternal cartilage have demonstrated improvements in joint symptoms. It may also enhance the effects of standard therapies for conditions like rheumatoid arthritis. Individuals with osteoarthritis, especially knee OA, may experience significant benefits, with studies reporting improvements in joint pain and function within weeks to months of supplementation. However, effect sizes can vary, and further research is needed to confirm these benefits across diverse populations and conditions. The evidence suggests that Type II collagen can be a valuable addition to a comprehensive joint health management plan.

How it works

Type II collagen is believed to work by reducing inflammation and modulating the immune response to joint damage. It interacts with both the musculoskeletal and immune systems. While the precise molecular targets are not fully defined, it likely involves the modulation of inflammatory cytokines, which are key players in the inflammatory processes associated with joint conditions like osteoarthritis. The bioavailability of oral collagen supplements is generally considered low, but specific mechanisms may enhance absorption. Further research is needed to fully elucidate the mechanisms of action and optimize its effectiveness.

Side effects

Type II collagen is generally considered safe with minimal side effects reported. Common side effects are rare, but some individuals may experience mild gastrointestinal issues. Uncommon and rare side effects are not well-documented. No significant drug interactions have been reported. However, caution is advised for individuals with severe allergies to chicken products. Pregnant or breastfeeding women should consult healthcare providers before use. While generally safe, it's important to be aware of potential allergic reactions and to discontinue use if any adverse effects occur. As with any supplement, it's best to consult with a healthcare professional before starting Type II collagen, especially if you have underlying health conditions or are taking other medications.

Dosage

The minimum effective dose of Type II collagen typically ranges from 40 mg to several hundred milligrams per day. For joint health, doses around 40 mg of UC-II have shown efficacy. The maximum safe dose is not well-established, but high doses are generally not recommended without medical supervision. Consistent daily dosing is recommended for optimal results. Type II collagen is often available in capsule or powder form. Bioavailability may be enhanced by specific formulations or co-administration with other nutrients. There are no specifically identified required cofactors. It's important to follow the recommended dosage guidelines and consult with a healthcare professional to determine the appropriate dosage for individual needs.

FAQs

How long does it take to see benefits?

Benefits from Type II collagen supplementation are typically observed within weeks to months of consistent use. Individual results may vary.

Is it safe for pregnant women?

Pregnant or breastfeeding women should consult a healthcare provider before using Type II collagen to ensure safety.

How should I take Type II collagen?

Type II collagen should be taken consistently once daily, following the recommended dosage guidelines provided by the manufacturer or a healthcare professional.

What results can I expect?

Users may experience reduced joint pain and inflammation with consistent use of Type II collagen, but individual results can vary.

Can Type II collagen cure osteoarthritis?

Type II collagen may help manage symptoms of osteoarthritis but is not a cure. It can be a valuable part of a comprehensive treatment plan.

Research Sources

  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10180699/ – This systematic review and meta-analysis examines the effects of collagen supplementation on joint health. While not specifically focused on Type II chicken collagen, it provides relevant insights into the broader benefits of collagen for reducing joint pain and improving function. The review highlights the variability in study quality and collagen types used, suggesting the need for more targeted research.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10058045/ – This randomized controlled trial (RCT) investigated the effects of UC-II for knee osteoarthritis, with 34 patients per group. The study found that UC-II supplementation improved joint symptoms compared to placebo over a 12-week period. While the RCT design strengthens the evidence, the small sample size limits the generalizability of the findings.
  • https://www.clinexprheumatol.org/article.asp?a=21013 – This study is a systematic review on the effects of collagen for skin and joint health. The review included multiple studies and found that collagen supplements show promise for both skin and joint health. The heterogeneity in study designs and outcomes was noted as a limitation, but the comprehensive nature of the review provides a high-quality overview of the existing evidence.
  • https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-collagen-peptide-supplementation-on-cardiovascular-markers-a-systematic-review-and-metaanalysis-of-randomised-placebocontrolled-trials/D1BD51038B71D9A9BCA7880B1F6649F0 – This systematic review and meta-analysis of randomized placebo-controlled trials investigates the effects of collagen peptide supplementation on cardiovascular markers. The study provides insights into the broader effects of collagen supplementation. The review highlights the need for more targeted research.
  • https://www.nmi.health/wp-content/uploads/2023/02/NMJ_Collagen_A-Review-of-Clinical-Use-and-Efficacy.pdf – This review examines the clinical use and efficacy of collagen supplements. The review provides insights into the broader effects of collagen supplementation. The review highlights the need for more targeted research.

Recommended Articles

Top Nutrients for Radiant Skin: What You Need to Know

Top Nutrients for Radiant Skin: What You Need to Know

A balanced diet rich in vitamins A, C, D, E, antioxidants, omega-3 fatty acids, and zinc is essential for healthy skin.

Top Joint Supplements: Evidence-Based Guide

Top Joint Supplements: Evidence-Based Guide

Clinical studies highlight curcumin, boswellic acid, glucosamine, chondroitin, type II collagen, omega-3 fatty acids, and green lipped mussel as effective for joint health.

Top Zinc Forms for Best Absorption & Dosage Guide

Top Zinc Forms for Best Absorption & Dosage Guide

Zinc picolinate is the most absorbable form of zinc, with an RDA of 8-11 mg/day for adults, affected by dietary factors.

Timing Matters: Maximizing Ingredient Efficacy

The effectiveness of ingredients across various fields can be significantly enhanced by optimizing the timing of their use.