Ulmus Davidiana Root Extract
Also known as: Ulmus davidiana root extract, David elm root extract, Ulmus davidiana var. japonica
Overview
Ulmus davidiana root extract is derived from the root bark of the Ulmus davidiana tree, a species traditionally utilized in East Asian medicine for its purported anti-inflammatory and anticancer properties. This extract contains various bioactive compounds, notably polysaccharides and flavonoids, which are believed to contribute to its therapeutic effects. Current research suggests its potential applications in areas such as dermatology, particularly for skin inflammation, as well as in vascular health and bone repair. While traditional use is extensive, scientific investigation into Ulmus davidiana root extract is still in its early stages. The existing evidence base primarily consists of preclinical studies, including in vitro and animal models, with a notable scarcity of high-quality human randomized controlled trials (RCTs). This limits definitive conclusions regarding its efficacy and safety in human populations, necessitating further rigorous clinical research.
Benefits
Ulmus davidiana root extract shows several potential benefits, primarily supported by preclinical research. It has demonstrated **vasorelaxation** in rat models, with an ethanol extract inducing dose-dependent relaxation via endothelial nitric oxide synthase activation, suggesting cardiovascular benefits. Traditionally, it's used for its **anti-inflammatory and anticancer potential**, though direct clinical evidence for these uses is limited. In the realm of **bone repair and osteogenesis**, animal studies indicate that the extract can improve lumbar vertebral parameters in osteopenic rats, promoting osteoblastic proliferation and bone callus formation, which points to its utility in bone health and fracture healing. Furthermore, polysaccharides from the root bark exhibit **cosmeceutical properties** relevant to skin health, including enhancing fibroblast proliferation and providing anti-inflammatory effects, supporting its traditional use for skin inflammation and potentially wound healing. While promising, the strength of evidence for these benefits is largely based on in vitro and animal studies, with human clinical trials being scarce.
How it works
The mechanism of action for Ulmus davidiana root extract involves several pathways. Its **vascular effects** are primarily mediated by the activation of endothelial nitric oxide synthase (eNOS), leading to increased nitric oxide production. This, in turn, causes smooth muscle relaxation and vasodilation. For its **anti-inflammatory and antioxidant effects**, the extract's rich content of flavonoids and polysaccharides is believed to play a crucial role by reducing oxidative stress and modulating inflammatory cytokines, thereby contributing to tissue repair and overall anti-inflammatory responses. In **bone metabolism**, the extract appears to promote the proliferation and differentiation of osteoblasts, which are cells responsible for bone formation. This action likely accelerates bone callus formation and repair, possibly through its antioxidant and regenerative properties. While specific pharmacokinetic data are limited, the presence of bioavailable flavonoids and polysaccharides in ethanol extracts suggests that these compounds are absorbed and exert their effects within the body.
Side effects
The safety profile of Ulmus davidiana root extract is not yet comprehensively established in humans due to a lack of extensive clinical trials. Preclinical studies indicate a dose-dependent cytotoxicity risk: low concentrations (10–100 µg/ml in vitro) did not adversely affect endothelial cell viability, but higher doses were shown to reduce cell viability. This suggests that while lower doses may be tolerated, excessive intake could lead to cellular damage. No comprehensive human safety data or specific side effects have been reported in clinical settings. Traditional use implies a degree of tolerability, but this has not been rigorously validated through modern clinical research. Information regarding drug interactions and contraindications is also largely uncharacterized, necessitating caution. Therefore, individuals, especially those with pre-existing conditions or taking other medications, should exercise prudence. Specific safety data for special populations, such as pregnant or breastfeeding women, children, or the elderly, are currently unavailable, and its use in these groups is not recommended without further research.
Dosage
Due to the limited number of human randomized controlled trials (RCTs) on Ulmus davidiana root extract, there are currently no established clinical dosing guidelines for human use. Preclinical studies have utilized various concentrations and forms of the extract. In vitro studies, for instance, have employed ethanol extracts at microgram per milliliter concentrations, while animal models have used a range of doses depending on the research objective. The optimal dosage, appropriate timing of administration, and the most effective formulation for human consumption remain undetermined. Without robust human clinical data, it is not possible to specify recommended dosage ranges, upper limits, or safety thresholds for different purposes. Any use of this extract should be approached with caution, and individuals should consult with a healthcare professional, especially given the lack of comprehensive safety and efficacy data in humans.
FAQs
Is Ulmus davidiana root extract safe for human use?
While traditional use suggests some safety, comprehensive clinical trials are needed to confirm its safety and efficacy in humans. Preclinical studies show dose-dependent effects, with higher doses potentially toxic.
What conditions can it help with?
Preclinical evidence suggests potential benefits for vascular health, bone repair, and skin inflammation. Its traditional uses also include anti-inflammatory and anticancer purposes, but human data are scarce.
How soon do benefits appear?
Based on animal studies, effects can be observed over weeks. However, the timeline for benefits in humans is currently unknown due to a lack of clinical research.
Are there any known drug interactions?
There is no specific data available on drug interactions for Ulmus davidiana root extract. Caution is advised, and consultation with a healthcare professional is recommended if you are taking other medications.
Research Sources
- https://www.science.gov/topicpages/u/ulmus+davidiana+root – This source provides general information about Ulmus davidiana root, indicating its scientific classification and traditional uses. It serves as a broad overview of the plant's relevance in scientific and medicinal contexts.
- https://www.mdedge9-ma1.mdedge.com/dermatology/article/259186/aesthetic-dermatology/ulmus-davidiana-root-extract – This article discusses the application of Ulmus davidiana root extract in aesthetic dermatology. It highlights its potential benefits for skin health, likely focusing on its anti-inflammatory and fibroblast-modulating properties relevant to dermatological conditions.
- https://onlinelibrary.wiley.com/doi/10.1155/2018/5690816 – This source likely refers to a study or review that contributes to the understanding of Ulmus davidiana's biological activities. Given the context, it might discuss its general pharmacological properties or specific effects on certain biological systems.
- https://onlinelibrary.wiley.com/doi/10.1155/2019/1296153 – This URL points to a systematic review on plant extracts in bone repair, which includes Ulmus davidiana. The review synthesizes findings from animal studies, indicating positive effects on osteoblastic proliferation and bone callus formation, suggesting its potential in fracture healing.
- https://pubmed.ncbi.nlm.nih.gov/17111070/ – This PubMed link corresponds to the Eom et al., 2006 study, which investigated the cosmeceutical properties of polysaccharides from Ulmus davidiana root bark. The study demonstrated enhanced human fibroblast proliferation and anti-inflammatory effects in vitro, supporting its potential for skin health applications.
