Uncaria Tomentosa Bark Extract
Also known as: Uncaria tomentosa, Cat's Claw, Uña de Gato
Overview
Uncaria tomentosa, commonly known as Cat's Claw, is a plant native to the Amazon rainforest and has been traditionally used in folk medicine. Extracts from the stem bark, roots, and leaves are utilized, with aqueous and hydroethanolic extracts being the most studied. It is primarily recognized for its anti-inflammatory and immunomodulatory properties, making it a potential aid in managing inflammatory diseases such as osteoarthritis. Research includes systematic reviews and meta-analyses, indicating a moderate level of scientific investigation. While some studies demonstrate significant anti-inflammatory effects by reducing inflammatory markers like NF-κB and IL-6, more rigorous clinical trials are necessary to fully establish its efficacy and safety. The quality of available evidence varies, highlighting the need for further research to confirm its benefits and safety profile comprehensively.
Benefits
Uncaria tomentosa extracts have demonstrated potential anti-inflammatory benefits by decreasing inflammatory markers such as NF-κB and IL-6. A meta-analysis showed a significant reduction in IL-6 levels (SMD: −0.72, 95%CI: −1.15, −0.29, p = 0.001), suggesting clinical relevance for inflammatory conditions. Some evidence supports its use in osteoarthritis models, though more human studies are needed to confirm these findings. While generally considered safe, specific benefits for populations such as the elderly or pregnant individuals require further investigation. The time course of these benefits is not well-documented, necessitating additional research to understand the duration and consistency of effects.
How it works
Uncaria tomentosa extracts primarily act by modulating inflammatory pathways, leading to a reduction in NF-κB and IL-6 levels. These extracts interact with the immune system, potentially influencing cytokine production and inflammatory responses. NF-κB and IL-6 are key molecular targets through which Uncaria tomentosa exerts its anti-inflammatory effects. Specific data on the absorption and bioavailability of its active compounds are limited, requiring further investigation to fully understand its pharmacokinetic properties.
Side effects
Uncaria tomentosa is generally considered safe, with low toxicity reported in most studies. However, common side effects are not well-documented, necessitating further research to establish a comprehensive safety profile. Potential gastrointestinal issues have been noted, though not extensively studied. Specific rare side effects are also not well-documented. There are potential interactions with immunosuppressive drugs or blood thinners, although these interactions have not been extensively studied. Contraindications include pregnancy and breastfeeding due to a lack of sufficient safety data. Caution is advised for immunocompromised individuals or those with autoimmune diseases. More research is needed to fully characterize the side effect profile and potential drug interactions.
Dosage
The minimum effective dose of Uncaria tomentosa is not well-established and varies depending on the extract and the condition being treated. Typical dosage ranges from 250 mg to 1,000 mg per day, but optimal dosing requires further research. The maximum safe dose is not clearly defined, and caution is advised at high doses. There are no specific timing recommendations available. Aqueous and hydroethanolic extracts are commonly used. Limited data are available on factors affecting absorption. Due to the limited research, it is important to consult with a healthcare professional to determine an appropriate and safe dosage.
FAQs
Should I consult a healthcare professional before taking Uncaria tomentosa?
Yes, it is advisable to consult a healthcare professional before starting Uncaria tomentosa supplements, especially if you are taking other medications or have pre-existing health conditions, to ensure safety and avoid potential interactions.
Is Uncaria tomentosa safe to take?
While generally considered safe, potential interactions with other medications or conditions require caution. More research is needed to fully characterize its safety profile, so it's important to discuss with a healthcare provider.
When should I take Uncaria tomentosa?
There are no specific timing recommendations available for taking Uncaria tomentosa. Consistency is key, so choose a time that fits your routine. Consult with a healthcare provider for personalized advice.
How long does it take to see results from Uncaria tomentosa?
Anti-inflammatory effects may be noticeable within weeks of consistent use, though individual results vary. It is not a cure-all for inflammatory conditions, and more research is needed to fully understand its benefits and risks.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/38881881/ – This systematic review and meta-analysis of in vivo studies found that Uncaria tomentosa extracts exhibit anti-inflammatory and immunomodulatory effects by reducing NF-κB and IL-6 levels. The quality of the evidence was rated as moderate due to heterogeneity in study designs, highlighting the need for more standardized research.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1378408/full – This study investigates the anti-inflammatory and immunomodulatory effects of Uncaria tomentosa. The research suggests that the extract can modulate inflammatory pathways, potentially benefiting conditions characterized by inflammation.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1584840/full – This systematic review assessed the cytotoxic effects of Uncaria tomentosa extracts. The review found that some extracts showed low toxicity to normal cells, while others were potentially toxic, highlighting the variability in extract types and the need for careful evaluation.
- https://www.mdpi.com/2673-9623/2/1/1 – This study provides an overview of Uncaria tomentosa, discussing its traditional uses, chemical composition, and potential health benefits. It emphasizes the need for further research to fully understand its mechanisms of action and clinical applications.
- https://auctoresonline.org/article/in-vitro-and-in-vivo-approaches-to-evaluate-uncaria-tomentosa-bark-extract-loaded-fdofs-on-osteoarthritis-models – This in vitro and in vivo study evaluated the potential of Uncaria tomentosa bark extract in treating osteoarthritis models. The research suggests that the extract may have therapeutic benefits for osteoarthritis, but the findings are limited by the lack of human data and the small-scale study design.
