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Upcycled Postbiotic Blend

Also known as: Postbiotics, Inanimate probiotics, Microbial metabolites

Overview

Postbiotics are bioactive compounds produced during the fermentation process of beneficial microorganisms, such as lactic acid bacteria (*Lactobacillus*, *Bifidobacterium*), *Bacillus subtilis*, and *Saccharomyces cerevisiae*. These compounds include cell-free supernatants, exopolysaccharides, enzymes, cell wall fragments, short-chain fatty acids, and other metabolites. Postbiotics are used to promote gut health, immune system regulation, and overall gastrointestinal wellness. They are also incorporated into food and beverage products due to their stability and heat tolerance. Unlike probiotics, postbiotics are heat-stable and do not require the presence of living microorganisms, making them easier to integrate into various food products. Research on postbiotics is emerging, with growing scientific evidence supporting their health benefits. Studies include in vitro experiments, animal models, and human clinical trials, with systematic reviews and meta-analyses consolidating the evidence.

Benefits

Postbiotics offer several evidence-based benefits, primarily in immune system regulation and gut health. They have been shown to enhance immune function, with EpiCor postbiotic demonstrating improved immune responses in human clinical trials. In terms of gut health, postbiotics can improve gut barrier function and reduce symptoms of irritable bowel syndrome (IBS), as shown in a study on *Bacillus subtilis* DE111. Additionally, postbiotics may possess anti-inflammatory properties, contributing to reduced inflammation and improved overall health. Some studies also suggest potential antitumor and antiatherosclerotic effects, though more research is needed. A meta-analysis involving over 4800 children showed a lower incidence of respiratory infections in those receiving postbiotic supplements. Improvements in gut health and immune function have been observed within a few weeks to months of supplementation.

How it works

Postbiotics act through several mechanisms, including immunomodulation, enhancement of gut barrier function, and production of short-chain fatty acids and other bioactive compounds. They interact with the immune system and gastrointestinal tract, and potentially other systems such as the nervous system through the gut-brain axis. Postbiotics can target various molecular pathways involved in inflammation, immune response, and gut barrier integrity. Since postbiotics are not living organisms, they are more stable and can be easily absorbed and utilized by the body without needing to survive through the digestive tract.

Side effects

Postbiotics are generally considered safe due to their inanimate nature and stability, posing fewer risks than live probiotics. Common side effects are rare, and studies often report no significant adverse effects. There is limited evidence on uncommon or rare side effects, but individual reactions may occur, as with any supplement. No significant drug interactions have been reported, but caution is advised when using any new supplement, especially for individuals with underlying health conditions. There are no known contraindications, but consulting a healthcare provider before use is recommended. Pregnant or breastfeeding women and individuals with compromised immune systems should seek medical advice before using postbiotics.

Dosage

The minimum effective dose of postbiotics varies, but a recommended dose of 500 mg per day has been suggested for EpiCor postbiotic. Optimal dosages typically range from 500 mg to 1 gram per day. There is no established maximum safe dose, but high doses are generally not necessary due to their bioactive nature. Consistent daily intake is recommended for optimal benefits, and they can be formulated into various food products due to their heat stability. As bioactive compounds, their absorption is not dependent on survival through the digestive tract, and there are no known required cofactors for their efficacy.

FAQs

Are postbiotics safe?

Postbiotics are generally safe and do not carry the risks associated with live probiotics due to their inanimate nature and stability.

When should I take postbiotics?

Consistent daily intake is recommended, and postbiotics can be taken at any time of day for optimal benefits.

What results can I expect from taking postbiotics?

Improvements in gut health, immune function, and overall well-being can be expected within a few weeks to months of consistent use.

Are postbiotics the same as probiotics?

No, postbiotics are not the same as probiotics; they are inanimate and more stable, making them easier to incorporate into food products.

Research Sources

https://www.foodbusinessnews.net/articles/20326-postbiotic-ingredients-gaining-traction – This article discusses the increasing popularity of postbiotic ingredients in the food and beverage industry. It highlights their stability and ease of incorporation into various products, as well as their potential health benefits for consumers.
https://microbiologyjournal.org/a-critical-analysis-of-postbiotics-exploring-their-potential-impact-on-the-health-and-food-industries/ – This critical analysis explores the potential impact of postbiotics on the health and food industries. It examines their production methods, bioactive components, and potential applications in promoting human health and wellness.
https://www.mdpi.com/1467-3045/46/5/244 – This review provides an overview of postbiotic production and their various health benefits. It discusses their immunomodulatory, gut barrier enhancing, and anti-inflammatory effects, highlighting their potential as a valuable supplement.
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1306192/full – This study investigates the effects of postbiotics on gut microbiota composition and function. It explores their potential to modulate the gut microbiome and improve overall gastrointestinal health.
https://www.mdpi.com/2072-6643/12/8/2189 – This meta-analysis examines the impact of postbiotic supplementation on respiratory infections in children. The findings indicate a significantly lower incidence of respiratory infections in children receiving postbiotic supplements, suggesting a potential immune-boosting effect.