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Urox Proprietary Blend

Also known as: Crataeva nurvala, Equisetum arvense, Lindera aggregata, Three-leaf caper, Horsetail, Lindera, CratevoxTM, Urox Proprietary Blend

Overview

Urox Proprietary Blend is a well-researched herbal supplement composed of concentrated extracts from *Crataeva nurvala* (stem bark), *Equisetum arvense* (aerial parts), and *Lindera aggregata* (root). The combination aims to support bladder health and alleviate symptoms associated with overactive bladder (OAB) and urinary incontinence (UI). Utilized primarily for its therapeutic properties, this patented blend has undergone extensive clinical evaluation over the past 20 years, including 14 clinical trials and 4 peer-reviewed publications. It has demonstrated significant effectiveness in reducing urinary urgency, frequency, nocturia, and overall incontinence symptoms, showcasing its potential as an alternative treatment for lower urinary tract symptoms in both men and women.

Benefits

Clinical trials have shown that Urox Proprietary Blend significantly reduces urinary frequency, where the treatment group reported an average of 7.69 episodes per day compared to 10.95 in the placebo group, with a statistically significant odds ratio (OR) of 0.01. Additionally, nocturnal urination episodes were reduced to an average of 2.16 per night versus 3.14 in the placebo group, also yielding strong statistical improvement (OR 0.03). The blend notably enhances quality of life for users. These benefits were observed across diverse populations, particularly in adults averaging 63.5 years. The consistent effectiveness observed within 8 weeks of treatment points to a reliable therapeutic impact.

How it works

The mechanism of action of Urox Proprietary Blend is primarily linked to its ability to strengthen and tone the bladder wall and surrounding pelvic muscles, while also supporting connective tissue health. Although specific molecular mechanisms remain to be fully elucidated, the interaction with the urinary system helps in improving muscle tone and reducing symptoms of overactivity. The extraction method used for *Equisetum arvense* ensures optimal absorption and bioavailability of its components without depleting thiamine levels, thus enhancing its efficacy.

Side effects

Urox Proprietary Blend has demonstrated a favorable safety profile in clinical evaluations, with minimal reported side effects. There are no common side effects documented in the literature, and uncommon or rare adverse effects have not been identified. While no drug interactions are explicitly noted, it is advisable that users consult healthcare providers before adding new supplements, particularly if they are on other medications. The safety and efficacy of Urox in special populations, such as pregnant individuals or children, have not been adequately studied, warranting caution for these groups. Overall, it is considered safe for short-term use based on available evidence.

Dosage

The recommended dosage for Urox Proprietary Blend is 2 capsules daily, with each capsule containing 840 mg of the proprietary blend. While a specific minimum effective dose is not stated, this dosage aligns with both clinical trial protocols and manufacturer guidelines. There is no maximum safe dose noted beyond the recommended intake. Users are advised to take the capsules consistently at the same time each day to maintain optimal results. Factors affecting absorption are also addressed; the extraction process enhances bioavailability by neutralizing thiaminase-like enzymes present in *Equisetum arvense*.

FAQs

How long does it take to see results?

Significant improvements are typically observed within 8 weeks after starting treatment.

Are there any side effects?

The supplement has been shown to have minimal side effects in clinical trials, with no common adverse effects reported.

Can it be used with other medications?

It is advisable to consult a healthcare provider before using any new supplement, especially if on other medications.

Is it safe for long-term use?

The long-term safety profile is not extensively documented, but short-term use has been shown to be safe.

What can I expect in terms of symptom reduction?

Significant reductions in urinary frequency, nocturia, urgency, and total incontinence can be expected.

Research Sources

https://seipelgroup.com/urox/ – The Urox blend's formulation and applications for overactive bladder treatment are detailed, emphasizing its research background and clinical efficacy.
https://pubmed.ncbi.nlm.nih.gov/29385990/ – This study presents results from a randomized, double-blind, placebo-controlled trial confirming the efficacy of Urox in alleviating overactive bladder symptoms in adults.
https://www.researchgate.net/publication/322847365_Urox_containing_concentrated_extracts_of_Crataeva_nurvala_stem_bark_Equisetum_arvense_stem_and_Lindera_aggregata_root_in_the_treatment_of_symptoms_of_overactive_bladder_and_urinary_incontinence_A_phas – This publication discusses the clinical effects of Urox in treating urinary disorders, providing insights from controlled trials on its effectiveness and safety.
https://pubmed.ncbi.nlm.nih.gov/35947382/ – A follow-up study examining the long-term outcomes of Urox on patients with urinary symptoms and further confirming its benefits through controlled methodologies.
https://www.researchgate.net/publication/361465325_New_Kid_on_the_Block_The_Efficacy_of_Phytomedicine_Extracts_UroxR_in_Reducing_Overactive_Bladder_Symptoms_in_Rats – This animal study explored the mechanistic insights of Urox's effects on bladder overactivity, proposing potential pathways for its therapeutic applications.