Us Grown Organic Agricultural Hemp Extract
Also known as: Hemp, industrial hemp, agricultural hemp, US Grown Organic Agricultural Hemp Extract, Cannabis sativa L. (industrial hemp cultivars)
Overview
US Grown Organic Agricultural Hemp Extract is derived from organically cultivated industrial hemp plants, specifically *Cannabis sativa* L. cultivars containing less than 0.3% THC. This extract typically includes compounds from hemp flowers, leaves, seeds, or stalks, and is rich in cannabinoids, particularly cannabidiol (CBD), along with terpenes, fatty acids, and other phytochemicals. It is primarily used as a dietary supplement for general wellness, anxiety reduction, and its anti-inflammatory properties, as well as a source of essential fatty acids and nutrients. Key characteristics include its non-psychoactive nature due to low THC content, its richness in CBD, essential fatty acids, and antioxidants. Organic cultivation ensures the absence of synthetic pesticides or fertilizers. While extensive preclinical and clinical research exists for hemp-derived CBD, variability in product composition and regulatory challenges currently limit standardization for whole hemp extracts.
Benefits
The primary benefits of US Grown Organic Agricultural Hemp Extract are largely attributed to its CBD content and nutritional profile. CBD has demonstrated significant anxiolytic and anticonvulsant effects, supported by randomized controlled trials (RCTs) showing reductions in anxiety symptoms and seizure frequency in specific populations, such as those with epilepsy. Nutritional benefits, particularly from hempseed oil and extracts, include essential fatty acids (omega-3 and omega-6), amino acids, vitamins, and minerals, which contribute to cardiovascular and overall health. Secondary effects include potential anti-inflammatory and spasmolytic properties, though clinical evidence for these is less robust for whole extracts. Patients with epilepsy, individuals with anxiety disorders, and those seeking plant-based nutritional supplementation are the primary beneficiaries. For CBD, meta-analyses indicate moderate effect sizes for seizure reduction and anxiety improvement, with benefits often observed within weeks of consistent use. Nutritional benefits accrue over longer-term consumption.
How it works
The primary mechanism of action for US Grown Organic Agricultural Hemp Extract, particularly its CBD component, involves interaction with the endocannabinoid system. CBD indirectly modulates CB1 and CB2 receptors, influencing neurotransmitter release and inflammatory pathways. It also interacts with other molecular targets such as the serotonin 5-HT1A receptor and TRPV1 channels, which are involved in pain and inflammation modulation. These interactions contribute to its effects on the neurological system (anxiolytic, anticonvulsant), immune system (anti-inflammatory), and metabolic system (nutritional support). Oral bioavailability of CBD is generally low (6-19%) but can be enhanced by formulation and the presence of fats, such as those found in hempseed oil, which improves the absorption of lipophilic cannabinoids.
Side effects
US Grown Organic Agricultural Hemp Extract is generally well tolerated, with a good safety profile observed in clinical studies of CBD and hemp seed products. Common side effects, affecting more than 5% of users, include fatigue, diarrhea, and changes in appetite or weight, primarily associated with CBD. Uncommon side effects (1-5%) may include dry mouth, dizziness, and nausea. Rare side effects, occurring in less than 1% of users, can include elevations in liver enzymes, particularly with high-dose CBD. A significant concern is drug interactions, as CBD can inhibit cytochrome P450 enzymes, potentially altering the metabolism of other medications. Contraindications include caution in patients taking drugs metabolized by CYP450 enzymes, and insufficient safety data exists for use during pregnancy and breastfeeding. While pediatric epilepsy patients have been extensively studied, caution is advised for the elderly and individuals with hepatic impairment.
Dosage
For anxiolytic effects, CBD doses as low as 300 mg/day have shown efficacy, with optimal ranges typically between 300-600 mg/day. For nutritional benefits, common dosages for hempseed oil are 1-3 tablespoons (10-30 mL) per day. CBD doses up to 1500 mg/day have been safely used in clinical trials, and hempseed oil has a high safety margin. Oral administration with food is recommended to enhance bioavailability due to the lipophilic nature of cannabinoids. Consistent daily dosing is advised for achieving chronic effects. Full-spectrum hemp extracts may offer an 'entourage effect' due to the presence of multiple cannabinoids and terpenes, potentially differing in efficacy from CBD isolates. No specific cofactors are required, but consuming the extract with fat-containing meals significantly improves cannabinoid absorption.
FAQs
Is US Grown Organic Agricultural Hemp Extract psychoactive?
No, it contains less than 0.3% THC, which is an insufficient amount to cause any psychoactive or 'high' effects.
Can it cause a positive drug test?
It is possible, especially with full-spectrum extracts, if THC levels are not meticulously controlled, as trace amounts could accumulate and be detected.
How soon will benefits appear?
Benefits for anxiety and seizure reduction may be observed within weeks of consistent use, while nutritional benefits typically accrue over longer periods.
Is it safe for long-term use?
Generally, it is considered safe for long-term use, but comprehensive long-term studies specifically on whole hemp extracts are still limited.
Does organic cultivation improve efficacy?
Organic certification ensures the absence of synthetic pesticides and fertilizers but does not inherently alter the cannabinoid content or efficacy of the extract itself.
Research Sources
- https://agdatacommons.nal.usda.gov/articles/dataset/Data_from_Review_and_Meta-analysis_of_Industrial_Hemp_Product_and_Process_Data_to_Support_Environmental_Life_Cycle_Assessment/29473610 – This meta-analysis provided comprehensive data on hemp cultivation and processing, highlighting variability and data gaps in hemp product standardization. While focused on environmental impact, it indirectly informs the challenges in standardizing supplement effects.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11124073/ – This review from the European hemp industry identified major challenges related to cannabinoid content variability and the need for standardized testing. It emphasized the importance of robust regulatory frameworks for hemp products, reflecting industry practices rather than clinical efficacy.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7891210/ – This review article summarized the nutritional and bioactive properties of hemp, discussing CBD's anxiolytic and anticonvulsant effects. It also highlighted the nutritional benefits of hempseed, providing a comprehensive overview of the plant's potential.
- https://acsess.onlinelibrary.wiley.com/doi/10.1002/agg2.70018 – This source, likely a review or research article, contributes to the understanding of hemp's agricultural and chemical properties. It supports the broader context of hemp's composition and potential uses, though specific clinical findings are not detailed here.
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